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Currently displaying 161 - 180 of 1025 publications

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

J Hartwig, JB Metternich, N Nikbin, A Kirschning, SV Ley

Organic & Biomolecular Chemistry

(2014)

3611

(doi: 10.1039/c4ob00662c)

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide.

RJ Ingham, C Battilocchio, JM Hawkins, SV Ley

Beilstein J Org Chem

(2014)

641

(doi: 10.3762/bjoc.10.56)

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

C Battilocchio, JM Hawkins, SV Ley

Org Lett

(2014)

1060

(doi: 10.1021/ol403591c)

Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor

JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne

Chemistry A European Journal

(2014)

263

(doi: 10.1002/chem.201303736)

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

L Guetzoyan, RJ Ingham, N Nikbin, J Rossignol, M Wolling, M Baumert, NA Burgess-Brown, CM Strain-Damerell, L Shrestha, PE Brennan, O Fedorov, S Knapp, SV Ley

RSC Medicinal Chemistry

(2014)

540

(doi: 10.1039/c4md00007b)

Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium.

G Rouquet, DC Blakemore, SV Ley

Chemical communications (Cambridge, England)

(2014)

8908

(doi: 10.1039/c4cc03766a)

Oppenauer oxidation using hydrous zirconia catalysts and cerium oxide enhanced Sonogashira reactions in flow by low-level palladium perovskite catalysts

RS Chorghade, C Battilocchio, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

247

Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry

KR Knudsen, M Ladlow, Z Bandpey, SV Ley

Journal of Flow Chemistry

(2014)

(doi: 10.1556/jfc-d-13-00033)

Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids.

DM Allwood, DC Blakemore, AD Brown, SV Ley

J Org Chem

(2013)

328

(doi: 10.1021/jo402526z)

Fragment-based hit identification: Thinking in 3D

AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt

Drug Discovery Today

(2013)

1221

(doi: 10.1016/j.drudis.2013.07.011)

Design, synthesis and biological evaluation of a novel allosteric inhibitor of HSET that damages cancer cells with supernumerary centrosomes.

CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley

Molecular Cancer Therapeutics

(2013)

B96

(doi: 10.1158/1535-7163.TARG-13-B96)

An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.

M Baumann, IR Baxendale

Beilstein Journal of Organic Chemistry

(2013)

2265

(doi: 10.3762/bjoc.9.265)

Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst.

R Chorghade, C Battilocchio, JM Hawkins, SV Ley

Org Lett

(2013)

5698

(doi: 10.1021/ol4027107)

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley

Chemistry and Biology

(2013)

1399

(doi: 10.1016/j.chembiol.2013.09.012)

Flow-based, cerium oxide enhanced, low-level palladium sonogashira and heck coupling reactions by perovskite catalysts

C Battilocchio, BN Bhawal, R Chorghade, BJ Deadman, JM Hawkins, SV Ley

Israel Journal of Chemistry

(2013)

371

(doi: 10.1002/ijch.201300049)

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

PRD Murray, DL Browne, JC Pastre, C Butters, D Guthrie, SV Ley

Organic Process Research and Development

(2013)

1192

(doi: 10.1021/op4001548)

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

KA Roper, MB Berry, SV Ley

Beilstein J Org Chem

(2013)

1781

(doi: 10.3762/bjoc.9.207)