Publications listed chronologically by number:
Present-2010
912. Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II M. Gurský, D. Trnovcová, P. Lopatka, M. Markovič, P. Koóš, S. V. Ley, T. Gracza J. Org. Chem. 2025, 90, 14186-14194. (https://doi.org/10.1021/acs.joc.5c01799)
911. Straightforward, scalable, solution-phase synthesis of peptide bonds in flow Z.E. Wilson, E. Lopez, N.J. Flodén, C. Watkins, G. Bianchini, S.V. Ley Journal of Flow Chemistry, 2025, 15, 67-77. (https://doi.org/10.1007/s41981-025-00347-2).
910. Carbonylative transformations with Pd catalysts supported on bio-degradable urea-based polymer – Part A M. Markovič, P. Lopatka, P. Koóš, T. Soták, A. Ház, T. Gracza, S.V. Ley, M. Králik Catal.Today, 2024, 441, 114903.
(https://doi.org/10.1016/j.cattod.2024.114903).
909. Palladium catalysts supported on biodegradable urea-based polymers in synthesis with CO – Part B M. Markovič, P. Lopatka, P. Koóš, T. Soták, A. Ház, T. Gracza, S.V. Ley, M. Králik Catal.Today, 2024, 440, 114831. (https://doi.org/10.1016/j.cattod.2024.114831).
908. Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue S.C Schäfer, A.M. Voll, A. Bracher, S.V. Ley and F. Hausch Bioorg. Med. Chem. Lett., 2024, 104, 129728. (https://doi.org/10.1016/j.bmcl.2024.129728)
907. Continuous flow synthesis enabling reaction discovery
906. Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides S.E. Gatarz, O.M. Griffiths, H.A. Esteves, W.Jiao, P.Morse, E.L. Fisher, D.C. Blakemore and S.V. Ley J. Org. Chem. 2024, 89, 1898-1909. (https://doi.org/10.1021/acs.joc.3c02557).
905. Photoredox-Catalyzed Preparation of Sulfones Using Bis-Piperidine Sulfur Dioxide – An Underutilized Reagent for SO2Transfer O.M. Griffiths, H.A. Esteves, D.C. Emmet and S.V. Ley Chem. Eur.J.,2024, 30, e202303976 (6 pages). (https://doi.org/10.1002/chem.202303976)
904. Automated multistep synthesis of 2-pyrazolines in continuous flow R. Labes, J. C. Pastre, R. J. Ingham, C. Battilocchio, H. M. Marçon, M. C. F. C. B. Damião, D. N. Tran and S. V. Ley React. Chem. Eng., 2024, 9, 558-565. (https://doi.org/10.1039/D3RE00515A).
903. The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation S. L. Bourne, F. Amann, S. V. Ley, Chimia 2023, 77, 288-293. (https://doi.org/10.2533/chimia.2023.288).
902. Exploring the chemical space of phenyl sulfide oxidation by automated optimization
901. Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis O. M. Griffiths and S. V. Ley, J. Org. Chem. 2022, 87, 13204−13223.(https://doi.org/10.1021/acs.joc.2c01684).
900. Automated Multi-Objective Reaction Optimisation: Which Algorithm Should I Use? P. Müller, A. D. Clayton, J. Manson, S. Riley, O. S. May, N. Govan, S. Notman, S. V. Ley, T. W. Chamberlain and R. A. Bourne, Reac. Chem. Eng. 2022, 7, 987-993. (https://doi.org/10.1039/d1re00549a)
899. Outlook, Future Directions, and Future Applications S.V. Ley. O.S. May, O.M. Griffiths and K. Sowa in Flow Chemistry, 2nd Edition, Volume 2 – Applications edited by F. Darvas, G. Dormán, V. Hessel and S.V. Ley, Berlin, Boston: De Gruyter, 2021, pp. 313-345. ISBN 978-3-11-069361-4.
898. Flow Chemistry – Fundamentals and Applications (Vol1&2 2nd Edition) edited by F. Darvas, G. Dormán, V. Hessel and S.V. Ley, Berlin, Boston: De Gruyter, 2021. Fundamentals and Applications (available as a set) Set-ISBN 978-3-11-073679-3. https://doi.org/10.1515/9783110693676
897. Process Intensification: From Green Chemistry to Continuous Processing, C. Battilocchio, S.V. Ley and E. Godineau in Sustainable Organic Synthesis: Tools and Strategies S. Protti and A. Palmieri (Eds.). RSC, 2021, 522-548 (Ch. 19). Print ISBN978-1-83916-203-9; ePub eISBN978-1-83916-485-9.
896. Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow O.M. Griffiths, H.A. Esteves, Y. Chen, K. Sowa, O.S. May, P. Morse, D.C. Blakemore, and S.V. Ley J. Org. Chem. 2021, 86, 13559-13571. (https://doi.org/10.1021/acs.joc.1c01621).
895. Enzymatic pretreatment of recycled grease trap waste in batch and continuous-flow reactors for biodiesel production, N.N. Tran, M. Escribà Gelonch, S. Liang, Z. Xiao, M. Mohsen Sarafraz, M. Tišma, H-J. Federsel, S.V. Ley, V. Hessel, Chemical Engineering Journal, 2021, 426, 131703. (https://doi.org/10.1016/j.cej.2021.131703).
894. Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions, H.R. Smallman, J.A. Leitch, T. McBride, S.V. Ley, D.L. Browne, Tetrahedron 2021, 93, 132305. (https://doi.org/10.1016/j.tet.2021.132305)
893. CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells, S. Roy, J. Sipthorp, B. Mahata, J. Pramanik, M. L. Hennrich, A-C. Gavin, S. V. Ley, S. A. Teichmann, iScience2021, 24, 102485. (https://doi.org/10.1016/j.isci.2021.102485)
892. A Comment on Continuous Flow Technologies within the Agrochemical Industry, S. V. Ley, Y. Chen, A. Robinson, B. Otter, E. Godineau, and C. Battilocchio, Org. Process Res. Dev. 2021, 25, 713–720. (https://doi.org/10.1021/acs.oprd.0c00534)
891. The Callipeltoside Story in Marine Natural Products: Topics in Heterocyclic Chemistry H. Kiyota (eds). Springer, Singapore 2020, 58, 467-517. Print ISBN 978-981-16-4636-2; Online ISBN978-981-16-4637-9.
890. Living with our machines: Towards a more sustainable future S. V. Ley, Y. Chen, D. E. Fitzpatrick and O. S. May Current Opinion in Green and Sustainable Chemistry 2020, 25, 100353. (https://doi.org/10.1016/j.cogsc.2020.100353)
889. Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin J. C. Pastre, P. R. D. Murray, D. L. Browne, G. A. Brancaglion, R. S. Galaverna, R. A. Pilli, S. V. Ley, ACS Omega 2020, 5, 18472–18483. (http://doi.org/10.1021/acsomega.0c02390)
888. Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins Y. Chen, N. McNamara, O. May, T. Pillaiyar, D. C. Blakemore, and S. V. Ley, Org. Lett. 2020, 22, 5746–5748. (https://doi.org/10.1021/acs.orglett.0c01730)
887. In silico rationalisation of selectivity and reactivity in Pd-catalysed C–H activation reactions L. Cao, M. Kabeshov, S. V. Ley, and A. A. Lapkin, Beilstein J. Org. Chem. 2020, 16, 1465–1475. (https://doi.org/10.3762/bjoc.16.122)
886. A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions D.E. Fitzpatrick, M. O’Brien, and S.V. Ley, React. Chem. Eng., 2020, 5, 201-220. (https://doi.org/10.1039/C9RE00407F)
885. A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters E. Watanabe, Y. Chen, O. May, and S. V. Ley, Chem. Eur. J. 2020, 26, 186-191. (https://doi.org/10.1002/chem.201905048)
884. Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source P. Lopatka, M. Markovic, P. Kooś, S. V. Ley and T. Gracza, J. Org. Chem. 2019, 84, 14394−14406. (https://doi.org/10.1021/acs.joc.9b02453)
883. A New World for Chemical Synthesis? S. V. Ley, Y. Chen, D.E. Fitzpatrick, and O. May, CHIMIA 2019, 73, 792-802. (https://doi.org/10.2533/chimia.2019.792)
882. A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow Y. Chen, O. May, D. C. Blakemore, and S. V. Ley Org. Lett. 2019, 21, 6140−6144. (https://doi.org/10.1021/acs.orglett.9b02307)
881. Enabling Synthesis in Fragment-Based Drug Discovery by Reactivity Mapping: Photoredox-Mediated Cross-Dehydrogenative Heteroarylation of Cyclic Amines R. Grainger, T. D. Heighten, S. V. Ley, F. Lima, and C. N. Johnson Chem. Sci., 2019, 10, 2264-2271. (http://dx.doi.org/10.1039/c8sc04789h)
880. Direct Oxidation of Csp3−H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow M. Lesieur, C. Battilocchio, R. Labes, J. Jacq, C. Genicot, S. V. Ley and P. Pasau Chem. Eur. J., 2019, 25, 1203-1207. (https://doi.org/10.1002/chem.201805657)
879. Fast continuous alcohol amination employing a hydrogen borrowing protocol
878. Copper Catalysed Arylations of Amines and Alcohols with Boron-Based Acylating ReagentsA.W. Thomas and S.V. Ley, 2009, 121-154 (Ch. 4) in “Modern Acylation Methods” Ed. L. Ackermann ISBN 978-352731937-4.
877. Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow Y. Chen, M. Leonardi, P. Dingwall, R. Labes, P. Pasau, D. C. Blakemore, and S. V. Ley J. Org. Chem., 2018, 83 (24), 15558–15568. (https://doi.org/10.1021/acs.joc.8b02721)
876. Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server D.E. Fitzpatrick, T. Maujean, A.C. Evans, and S.V. Ley Angew. Chem. Int. Ed. 2018, 57, 15128 –15132. (http://dx.doi.org//10.1002/anie.201809080)
875. Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor Y. Chen, D.C. Blakemore, P. Pasau and S.V. Ley Org. Lett. 2018, 20, 6569-6572. (http://dx.doi.org//10.1021/acs.orglett.8b02907)
874. C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow P. Dingwall, A. Greb, L. N. S. Crespin, R. Labes, B. Musio, J.S. Poh, P. Pasau, D. C. Blakemore and S. V. Ley Chem. Comm. 2018, 54, 11685 – 11688. (http://dx.doi.org/10.1039/c8cc06202a)
873. In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system D. E. Fitzpatrick, R. J. Mutton and S. V. Ley React. Chem. Eng., 2018, 3, 799-806. (http://dx.doi.org/10.1039/C8RE00107C)
872. Integrated plug flow synthesis and crystallisation of pyrazinamide, C. D. Scott, R. Labes, M. Depardieu, C. Battilocchio, M. G. Davidson, S. V. Ley, C. C. Wilson and K. Robertson React. Chem. Eng., 2018, 3, 631-634. (http://dx.doi.org/10.1039/C8RE00087E)
871. Immobilised Reagents and Multistep Processes, S.V. Ley, D.L. Browne, and M. O’Brien Science of Synthesis, 2018, 9, 273-312 in Flow Chemistry in Organic Synthesis, Ed. T.F. Jamison and G. Koch, Georg Thieme Verlag KG, Stuttgart, Germany, ISBN 978-3-13-242331-2. (http://dx.doi.org// 10.1055/sos-SD-228-00177).
870. Preparation of homoallylic amines via a three-component coupling process
869. Engineering Chemistry to Enable Bioactive Small Molecule Discovery S.V.Ley, D. Fitzpatrick and C. Battilocchio 2018, 184-218 (Ch. 8) in Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, Ed. N.J. Westwood and A. Nelson, ISBN 978-1-78262-948-1. (http://dx.doi.org/10.1039/9781788012805-00184)
868. Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone M.O’Brien, A. Weber, G. Hardy, S.V. Ley Tetrahedron, 2018, 74, 5319-5329
867. A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles E. Godineau, C. Battilocchio, M. Lehmann, S. V. Ley, R. Labes, L. Birnoschi, S. Subramanian, C. S. Prasanna, A. Gorde, M. Kalbagh, V. Khade, A. Scherrer, and A. C. O’Sullivan Org. Process Res. Dev. 2018, 22, 955-962
866. Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow F. Lima, L. Grunenberg, H.B.A. Rahman, R. Labes, J. Sedelmeier and S.V. Ley Chem. Commun., 2018, 54, 5606-5609
865. Engineering chemistry for the future of organic synthesis D.E. Fitzpatrick and S.V. Ley Tetrahedron, 2018, 74, 3087-3100
864. Engineering chemistry for the future of organic synthesis S.V. Ley Tetrahedron, 2018, 74, 3085(Preface)
863. Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry D. J. Ritson, C. Battilocchio, S.V. Ley and J. D. Sutherland Nature Communications 2018, 9, 1821[DOI:10.1038/s41467-018-04147-2 | www.nature.com/naturecommunications]
862. The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony Steven V. Ley Angew. Chem. Int. Ed. 2018, 57, 5182 – 5183
861. Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species J. A. Forni, S-H. Lau, J-S. Poh, C. Battilocchio, S.V. Ley and J.C. Pastre Synlett 2018, 29, 825–829
860. Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides J. Döbber, M. Pohl, S. V. Ley and B. Musio React.Chem.Eng., 2018, 3, 8–12
859. Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow B. Musio, E. Gala, and S. V. Ley ACS Sustainable Chem. Eng. 2018, 6, 1489−1495
858. A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross-Coupling Reactions A. Greb, J-S. Poh, S. Greed, C. Battilocchio, P. Pasau, D. C. Blakemore and S. V. Ley Angew. Chem. Int. Ed. 2017, 56, 16602 –16605
857. Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives L.N.S. Crespin, A. Greb, D.C. Blakemore, and S.V. Ley J. Org. Chem. 2017, 82, 13093−13108
856. Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines R. Labes, D. González-Calderón, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J. A. Rincón, and S. V. Ley, Synlett 2017, 28, 2855-2858
855. Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides M.A. Kabeshov, B. Musio and S.V. Ley, React. Chem. Eng., 2017, 2, 822-825
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters F. Lima, U.K. Sharma, L. Grunenberg, D. Saha, S. Johannsen, J. Sedelmeier, E.V. Van der Eycken and S.V. Ley, Angew. Chem. Int. Ed., 2017, 56, 15136-15140
853. Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines C. Battilocchio, F. Bosica, S.M. Roew, B.L. Abreu, E. Godineau, M. Lehmann and S.V. Ley, Org. Process Res. Dev., 2017, 21, 1588-1594
852. Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols R. Labes, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón, K. Binder and S.V. Ley, Org. Process. Res. Dev., 2017, 21, 1419-1422
851. Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids C. Bomio, M.A. Kabeshov, A.R. Lit, S-H. Lau, J. Ehlert, C. Battilocchio and S.V. Ley, Chem. Sci., 2017, 8, 6071-6075
850. A new methodology for incorporating chiral linkers into stapled peptides J.C. Serrano, J. Sipthorp, W. Xu, L.S. Itzhaki and S.V. Ley, Chem. Bio. Chem., 2017, 18, 1066-1071
849. Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S.V. Ley, React. Chem. Eng., 2017, 2, 295-298
848. Utilization of flow chemistry in catalysis: new avenues for the selective synthesis of bis(indolyl)methanes S.S. Mohapatra, Z.E. Wilson, S. Roy, S.V. Ley, Tetrahedron, 2017, 73, 1812-1819
847. One-pot acid-Catalyzed ring-opening/cyclization/oxidation of aziridines with N-tosylhydrazones: access to 1,2,4-triazines L. Crespin, L. Biancalana, T. Morack, D.C. Blakemore, S.V. Ley Org. Lett., 2017, 19, 1084-1087
846. Rapid asymmetric synthesis of disubstituted allenes by coupling of flow-generated diazo compounds and propargylated amines J-S. Poh, S. Makai, T. v.Keutz, D.N. Tran, C. Battilocchio, P. Pasau, S.V. Ley Angew. Chem. Int. Ed. 2017, 56, 1864-1868
845. Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor C. Battilocchio, S-H. Lau, J.M. Hawkins, S.V. Ley Org. Synth. 2017, 94, 34-45
844. On the synthesis and reactivity of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones C.L. Sutherell and S.V. Ley Synthesis, 2017, 49, 135-144
843. Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform D.E. Fitzpatrick and S.V. Ley, React. Chem. Eng. 2016, 1, 629-635
842. Visible light activation of boronic esters enables efficient photoredox C(sp2)-C(sp3) cross-couplings in flow F. Lima, M.A. Kabeshov, D.N. Tran, C. Battilocchio, J. Sedelmeier, G. Sedelmeier, B. Schenkel, S.V. Ley, Angew. Chem. Int. Ed. 2016, 55, 14085-14089
841. The total synthesis of the bioactive natural product Plantazolicin A and its biosynthetic precursor Plantazolicin B S. Fenner, Z.E. Wilson, S.V. Ley, Chem. Eur. J. 2016, 22, 15902-15912
840. A multicomponent approach for the preparation of homoallylic alcohols J-S. Poh, S-H. Lau, I.G. Dykes, D.N. Tran, C. Battilocchio, S.V. Ley, Chem. Sci. 2016, 7, 6803-6807
839. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia S. Picaud, K. Leonards, J-P. Lambart, O. Dovey, C. Wells, O. Federov, O. Monteiro, T. Fujisawa, C-Y. Wang, H. Lingard, C. Tallant, N. Nikbin, L. Guetzoyan, R.J. Ingham, S.V. Ley, P. Brennan, S. Müller, A. Samsonova, A-C. Gingras, J. Schwaller, G. Vassiliou, S. Knapp, P. Filippakopoulos, Science Adv. 2016, 2, e1600760
838. Flow Chemistry in Europe V. Hessel and S.V. Ley, J. Flow. Chem., 2016, 6, 135
837. Combination of enabling technologies to improve and describe the stereoselectivity of Wolff–Staudinger cascade reaction B. Musio, F. Mariani, E.P. Sliwinski, M.A. Kabeshov, H. Odajima, S.V. Ley, Synthesis, 2016, 48, 3515-3526
836. Continuous processing and efficient in situ reaction monitoring of hypervalent iodine(III) mediated cyclopropanation using benchtop NMR spectroscopy B. Ahmed-Omer, E. Sliwinski, J.P. Cerroti, S.V Ley, Org. Process Res. Dev. 2016, 20, 1603-1614
835. Taming hazardous chemistry by continuous flow technology M. Movsisyan, E.I.P. Delbeke, J.K.E.T. Berton, C. Battilocchio, S.V. Ley, C.V. Stevens, Chem. Soc. Rev. 2016, 45, 4892-4928
834. Editorial – flow chemistry and catalysis S.V. Ley, Catal. Sci. Technol. 2016, 6, 4676-4677
833. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation J-S. Poh, C. García-Ruiz, A. Zúñiga, F. Meroni, D.C. Blakemore, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2016, 14, 5983-5991
832. Controlled generation and use of CO in flow S.V.F. Hansen, Z.E. Wilson, T. Ulven, S.V. Ley React. Chem. Eng. 2016, 1, 280-287
831. Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex C.L. Sutherell, C. Tallant, O.P Monteiro, C. Yapp, J.E. Fuchs, O. Fedorov, P. Siejka, S. Müller, S. Knapp, J.D. Brenton, P.E. Brennan, S.V. Ley J. Med. Chem. 2016, 59, 5095-5101
830. Solvent-free continuous operations using small footprint reactors: a key approach for process intensification T. Ouchi, R.J. Mutton, V. Rojas, D.E. Fitzpatrick, D.G. Cork, C. Battilocchio, S.V. Ley ACS Sustainable Chem. Eng. 2016, 4, 1912-1916
829. Enabling technologies for the future of chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley ACS Central Science 2016, 2, 131-138
828. Iterative reactions of transient boronic acids enable sequential C-C bond formation C. Battilocchio, F. Feist, A. Hafner, M. Simon, D.N. Tran, D.M. Allwood, D.C. Blakemore, S.V. Ley Nature Chem. 2016, 8, 360-367
827. Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry D. Lücke, T. Dalton, S.V. Ley, Z.E. Wilson Chem. Eur. J. 2016, 22, 4206-4217
826. (S)-5-Pyrrolidin-2-yltetrazole and (R)-5-Pyrrolidin-2-yltetrazole Second Update R.J. Mutton, S.V. Ley, Electronic Encyclopaedia of Reagents in Organic Synthesis. Ed. L.A. Paquette 2016
825. A novel internet-based reaction monitoring, Control and autonomous self-optimization platform for chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley Org. Process. Res. Dev 2016, 20, 386-394
824. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process J-S. Poh, D.L. Browne, S.V. Ley React. Chem. Eng. 2016, 1, 101-105
823. An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins A. Brahma, B. Musio, U. Ismayilova, N. Nikbin, S.B. Kamptmann, P. Siegert, G.E. Jeromin, S.V. Ley, M. Pohl Synlett 2016, 27, 262-266
822. Dynamic flow synthesis of porous organic cages M.E. Briggs, A.G. Slater, N. Lunt, S. Jiang, M.A. Little, R.L. Greenaway, T. Hasell, C. Battilocchio, S.V. Ley, A.I. Cooper Chem. Commun. 2015, 51, 17390-17393
821. Synthesis of a precursor to sacubitril using enabling technologies S-H. Lau, S.L. Bourne, B. Martin, B. Schenkel, G. Penn, S.V. Ley Org. Lett. 2015, 17, 5436-5439
820. The ‘Internet of Chemical Things‘ S.V. Ley, D.E. Fitzpatrick, R.J. Ingham, N. Nikbin Beilstein Magazine 2015, 1, 11-12
819. Callipeltosides A, B and C: total syntheses and structural confirmation J.R. Frost, C.M. Pearson, T.M. Snaddon, R.A. Booth, R.M. Turner, J. Gold, D.M. Shaw, M.J. Gaunt, S.V. Ley Chem. Eur. J. 2015, 21, 13261-13277
818. Machine-assisted organic synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 2015, 54, 10122-10136
817. Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors De Lucia, O Méndez Lucio, B. Musio, A. Bender, M. Listing, S. Dennhardt, A. Koeberle, U. Garscha, R. Rizzo, S. Manfredini, O. Werz, S.V. Ley Eur. J. Med. Chem. 2015, 101, 573-583
Corrigendum to Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors
816. A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1 L. de c. Alves, A.L. Desiderá, K.T. de Oliveira, S. Newton, S.V. Ley, T.J Brocksom Org. Biomol. Chem. 2015, 13, 7633-7642
815. Continuous flow metathesis for direct valorization of food waste: an example of cocoa butter triglyceride C. Schotten, D. Plaza, S. Manzini, S.P. Nolan, S.V. Ley, D.L. Browne, A. Lapkin ACS Sustainable Chem. Eng. 2015, 3, 1453-1459
814. Machines vs malaria: a flow-based preparation of the drug candidate OZ439 S-H Lau, A. Galván, R.R. Merchant, C. Battilocchio, J.A. Souto, M.B. Berry, S.V. Ley Org. Lett. 2015, 17, 3218-3221
813. Modeling mesoscale reactors for the production of fine chemicals P.W. Witt, S. Somasi, I. Khan, D.W. Blaylock, J.A. Newby, S.V. Ley Chem. Eng. J. 2015, 278, 353-362
812. A versatile room-temperature route to di- and trisubstituted allenes using flow-generated diazo compounds J.S. Poh, D.N. Tran, C. Battilocchio, J.M Hawkins, S.V. Ley Angew. Chem. Int. Ed. 2015, 54, 7920-7923
811. Generation of reactive ketenes under flow conditions through zinc-mediated dehalogenation A. Hafner, S.V. Ley Synlett, 2015, 26, 1470-1474
810. Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods S.B. Kamptmann, S.V. Ley Aust. J. Chem. 2015, 68, 693-696
809. Development of a web-based platform for studying lithiation reactions in silico M.A. Kabeshov, E. Sliwinski, D.E. Fitzpatrick, B. Musio, J.A. Newby, W.D.W. Blaylock, S.V. Ley Chem. Commun. 2015, 51, 7172-7175
808. Development of a flow method for the hydroboration/oxidation of olefins J.A. Souto, R.A. Stockman, S.V.Ley Org. Biomol. Chem. 2015, 13, 3871-3877
807. Design, synthesis and evaluation of tetra substituted pyridines as potent 5-HT2C receptor agonists G. Rouquet, D.E. Moore, M. Spain, D.M. Allwood, C. Battilocchio, D.C. Blakemore, P.V. Fish, S. Jenkinson, A.S. Jessiman, S.V. Ley, G. McMurray, R.A.Storer, ACS Med. Chem. Lett. 2015, 6, 329-333
806. Chemistry in a changing world S.V. Ley, R.M. Myers, D.E. Fitzpatrick L’Actualite Chimique, Fevrier-Mars 2015, 393-394, 96-101
805. Organic synthesis: march of the machines S.V. Ley, D.E.Fitzpatrick, R.J. Ingham, R.M. Myers Angew. Chem. Int. Ed. 2015, 54, 3449-3464
804. Cyclopropanation using flow generated diazo compounds N.M. Roda-Monsalvez, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M.Hawkins, S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554
803. Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor M. Brzozowski, M. O’Brien, S.V. Ley, A. Polyzos Acc. Chem. Res. 2015, 48, 349-362
802. Back pressure regulation of slurry-forming reactions in continuous flow B.J. Deadman, D.L. Browne, I.R. Baxendale, S.V. Ley Chem. Eng. Technol. 2015, 38, 259-264
801. Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds D.N. Tran, C. Battilocchio, S. Lou, J. M. Hawkins, S.V. Ley Chem. Sci. 2015, 6, 1120-1125
800. Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B Z.E. Wilson, S. Fenner, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 1284-1288.
799. A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences R.J. Ingham, C. Battilocchio, D.E. Fitzpatrick, E. Sliwinski, J.M. Hawkins, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 144-148.
798. The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions S. Glockner, D.N. Tran, R.J. Ingham, S. Fenner, Z.E. Wilson, C. Battilocchio, S.V. Ley Org. Biomol. Chem. 2015, 13, 207.
797. Process intensification for the continuous flow hydrogenation of ethyl nicotinate T. Ouchi, C. Battilocchio, J.M. Hawkins, S.V. Ley Org. Process Res. Dev., 2014, 18, 1560-1566.
796. Reconfiguration of a continuous flow platform for extended operation: application to a cryogenic fluorine-directed ortho-lithiation reaction J.A. Newby, D.W. Blaylock, P.M. Witt, R.M. Turner, P.L. Heider, B.H. Harji, D.L. Browne, S.V. Ley Org. Process Res. Dev., 2014, 18, 1221-1228.
795. Design and application of a low-temperature continuous flow chemistry platform J.A. Newby, D.W. Blaylock, P.M. Witt, J.C. Pastre, M.K. Zacharova, S.V. Ley, D. L. Browne, Org. Process Res. Dev. 2014, 18, 1211-1220.
794. A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas-liquid microreactors U. Gross, P. Koos, M. O’Brien, A. Polyzos, S.V. Ley, Eur. J. Org. Chem. 2014, 6418-6430.
793. Regioselective preparation of saturated spirocyclic ring-expanded fused pyrazoles R.R. Merchant, D.M.Allwood, D.C.Blakemore, S.V.Ley, J. Org. Chem. 2014, 880-8811.
792. Flow chemistry meets advanced functional materials R.M. Myers, D.E. Fitzpatrick, R.M. Turner, S.V. Ley Chem. Eur. J. 2014, 20, 12348-12366.
791. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology M.A. Kabeshov, B. Musio, P.R.D. Murray, D.L. Browne, S.V. Ley Org. Lett. 2014, 16, 4618-4621.
790. Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium G. Rouquet, D.C. Blakemore, S.V. Ley Chem. Comm. 2014, 50, 8908-8911.
789. Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations, M. Baumann, I.R. Baxendale, C.H. Hornung, S.V. Ley, M.V. Rojo, K.A. Roper Molecules 2014, 19, 9736-9759.
788. Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C-H bond insertion, D.M. Allwood, D.C. Blakemore, S.V. Ley Org. Lett. 2014, 16, 3064-3067.
787. Synthesis and use of trifluoromethylated azomethine ylide precursor: ethyl 1-benzyl-trans-5-(trifluoromethyl) pyrrolidine-3-carboxylate D.M. Allwood, D.L. Browne, S.V. Ley, Org. Synth. 2014, 91, 162-174
786. Continuous flow chemistry: a discovery tool for new chemical reactivity patterns J. Hartwig, J.B. Metternich, N. Nikbin, A. Kirschning, S.V. Ley, Org. BioMol. Chem. 2014, 12, 3611.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry S. Newton, C.F. Carter, C.M. Pearson, L.C. Alves, H. Lange, P. Thansandote, S.V. Ley, Angew. Chem. Int. Edn. 2014, 53, 4915-4920.
784. Flow based cerium oxide-enhanced low-level palladium Sonogashira and Heck coupling reactions by perovskite type oxide catalysts C. Battilocchio, B.N. Bhawal, R. Chorghade, B.J. Deadman, J.M. Hawkins, S.V. Ley, Israel Journal of Chem. 2014, 54, 371-380.
783. Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography L. Guetzoyan, R. Ingham, N. Nikbin, J. Rossignol, M. Wolling, M. Baumert, N.A. Burgess-Brown, C.M. Strain-Damerell, L. Shrestha, P. Brennan, O. Fedorov, S. Knapp, S.V Ley, Med. Chem. Commun. 2014, 5, 540-546
782. Fully automated sequence-specific synthesis of alpha-peptides using flow chemistry K. Rahbek-Knudsen, M. Ladlow, Z. Bandpey, S.V. Ley, J. Flow. Chem. 2014, 4, 18-21
781. Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide R.J. Ingham, C. Battilocchio, J. M. Hawkins and S.V. Ley, Beilstein J. Org. Chem. 2014, 10, 641-652.
780. Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2014, 16, 1060-1063.
779. Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids D.M. Allwood, D.C. Blakemore, A.D. Brown, S.V. Ley, J. Org. Chem. 2014, 79, 328-338.
778. Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor J.A. Newby, L. Huck, D.W. Blaylock, P.M. Witt, S.V. Ley, D.L. Browne, Chem. Eur. J., 2014, 20, 263-271.
777. Fragment-based hit identification thinking in 3D A.D. Morley, A. Pugliese, K. Birchall, J. Bower, P. Brennan, N. Brown, T. Chapman, M. Drysdale, I.H. Gilbert, S. Hoelder, A. Jordan, S.V. Ley, A. Merritt, D. Miller, M.E. Swarbrick, P.G. Wyatt, Drug Discovery Today, 2013, 18, 1221-1227.
776. Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes C.A. Watts, F.R. Richards, A. Bender, P.J. Bond, O. Korb, O. Kern, M. Riddick, P. Owen, R.M. Myers, J. Raff, F. Gergely, D.I. Jodrell, S.V. Ley, Chem. Biol. 2013, 20, 1399–1410.
775. Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst R. Chorghade, C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2013, 15, 5698-5701.
774. Flow chemistry syntheses of natural products J.C. Pastre, D.L. Browne, S.V. Ley, Chem. Soc. Rev. 2013, 42, 8801-9198.
773. Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen P.R.D. Murray, D.L. Browne, J.C. Pastre, C. Butters, D. Guthrie, S.V. Ley, Org. Proc. Res. Dev. 2013, 17, 1192-1208.
772. Scaling-up of continuous flow processes with gases using a tube-in-tube reactor: in-line titrations and fanetizole synthesis with ammonia J. Pastre, D.L. Browne, M. O’Brien, S.V. Ley, Org. Proc. Res. Dev. 2013, 17, 1183-1191.
771. The application of a monolithic triphenylphosphine reagent for conducting gem-dibromoolefination reactions in flow K.A. Roper, M.B. Berry, S.V. Ley, Beilstein J. Org. Chem. 2013, 9,1781-1790.
770. Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release C. Battilocchio, L. Guetzoyan, C. Cervetto, L. Di Cesare Mannelli, D. Frattaroli, I. R. Baxendale, G. Maura, A. Rossi, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S.V. Ley, A.C.S. Med. Chem. Lett. 2013, 4, 704-709.
769. A continuous flow solution to achieving efficient, aerobic anti-Markovnikov Wacker oxidation S.L. Bourne, S.V. Ley, Adv. Synth. Catal. 2013, 355, 1905-1910.
768. A prototype device for evaporation in batch and flow chemical processing B.J. Deadman, C. Battilocchio, E. Sliwinski, S.V. Ley, Green Chem., 2013, 15, 2050-2055.
767. The synthesis of neurotensin antagonist SR 48692 for prostate cancer research I.R. Baxendale, S. Cheung, M.O. Kitching, S.V. Ley, J.W. Shearman Bio. Org. Med. Chem. 2013, 21, 4378-4387.
766. Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor K. Nakayama, D.L. Browne, I.R. Baxendale, S.V. Ley, Synlett 2013, 24, 1298-1302.
765. A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1 C. Battilocchio, B.J. Deadman, N. Nikbin, M.O. Kitching, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2013, 19, 7917-7930.
764. Camera enabled techniques for organic synthesis S.V. Ley, R.J. Ingham, M. O’Brien, D.L. Browne, Beilstein J. Org. Chem. 2013, 9, 1051-1072.
763. Continuous cold without cryogenic consumables: development of a convenient laboratory tool for low temperature flow processes D.L. Browne, B.H. Harji, S.V. Ley, Chem. Eng. and Technol. 2013, 36, 959-967.
762. A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2013, 15, 2278-2281.
761. Synthesis of spongistatin 2 employing a new route to the EF fragment H. Kraus, A. Français, M. O’Brien, J.R. Frost, A. Diéguez-Vázquez, A. Polara, N. Baricordi, R. Horan, D-S. Hsu, T. Tsunoda, S.V. Ley, Chem. Sci. 2013, 4, 1989-1994.
760. An expedtious synthesis of imatinib and analogues utilising flow chemistry methods M.D. Hopkin, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem. 2013, 11, 1822-1839.
759. The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib B. Deadman, M.D. Hopkin, I.R. Baxendale, S.V. Ley, Org. Biomol. Chem. 2013, 11, 1766-1800.
758. Synthesis of (-)-hennoxazole A: integrating batch and flow chemistry methods A. Fernández, Z.G. Levine, M. Baumann, S. Sulzer-Mossé, C. Sparr, S. Schläger, A. Metzger, I.R. Baxendale, S.V. Ley, Synlett, 2013, 24, 514-518.
757. Flow microwave technology and microreactors in synthesis I.R. Baxendale, C. Hornung, S.V. Ley, J. de M. Muñoz Molina, A. Wikström, Aust. J. Chem., 2013, 66, 131-144.
756. Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography L. Guetzoyan, N. Nikbin, I.R. Baxendale, S.V. Ley, Chem. Sci., 2013, 4, 764-769.
755. Flow chemistry syntheses of styrenes, unsymmetrical stilbenes and branched aldehydes S.L. Bourne, M. O’Brien, S. Kasinathan, P. Koos, P. Tolstoy, D.X. Hu, R.W. Bates, B. Martin, B. Schenkel, S.V. Ley, ChemCatChem., 2013, 5, 159-172.
754. Synthesis and use of a new trifluoromethylated azomethine ylide precursor G. Tran, R. Meier, L. Harris, D.L. Browne, S.V. Ley, J. Org. Chem., 2012, 77, 11071-11078.
753. Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides P. Tolstoy, S.X.Y. Lee, C. Sparr, S.V. Ley, Org. Lett. 2012, 14, 4810-4813.
752. The evolution of immobilised reagents and their application in flow chemistry for the synthesis of natural products and pharmaceutical compounds by R.M. Myers, K.A. Roper, I.R. Baxendale and S.V. Ley. In “Modern Tools for the Synthesis of Complex Bioactive Molecules”, Ed. J. Cossy, S. Arseniyadis, J. Wiley, N.Y., ISBN 978-0-470-61618-5, 2012, Chapter 11, p. 359-394.
751. Total synthesis of callipeltosides A, B and C J.R. Frost, C.M. Pearson, T.N. Snaddon, R.A. Booth, S.V. Ley, Angew. Chem. Int. Ed. 2012, 51, 9366-9371.
750. Continuous multiple liquid–liquid separation: diazotization of amino acids in flow D.X. Hu , M. O’Brien, S.V. Ley, Org. Lett. 2012, 14, 4246-4249.
749. On being green: can flow chemistry help? S.V. Ley, Chem. Rec. 2012, 12, 378-390.
748. A prototype continuous-flow liquid–liquid extraction system using open-source technology M. O’Brien, P. Koos, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2012, 10, 7031-7036.
747. A “catch-react-release” method for flow synthesis of 2-aminopyrinidines and preparation of the imatinib base R.J. Ingham, E. Riva, N. Nikbin, I.R. Baxendale, S.V. Ley, Org. Lett. 2012, 14, 3920–3923.
746. Continuous flow reaction monitoring using an on-line miniature mass spectrometer D.L. Browne, S. Wright, B.J. Deadman, S. Dunnage, I.R. Baxendale, R.M. Turner, S.V. Ley, Rapid Commun. Mass Spectrom. 2012, 26, 1999-2010.
745. Flow synthesis using gaseous ammonia in a Teflon AF 2400 tube in tube reactor: Paal-Knorr formation and gas concentration measurement with in-line titration P.B. Cranwell, M. O’Brien, D. Browne, P. Koos, A. Polyzos, M. Pêna López, S.V. Ley, Org. Biomol. Chem. 2012, 10, 5774-5779.
744. A total synthesis of the ammonium ionophore (–)-enniatin B D.X. Hu, M. Bielitza, P. Koos, S.V. Ley, Tetrahedron Lett. 2012, 53, 4077-4079.
743. Asymmetric homogenous hydrogenation in flow using tube-in-tube reactor S. Newton, S.V. Ley, E.C. Arce, D. Grainger, Adv. Synth. Catal. 2012, 354, 1805-1812.
742. Rotamers or diastereomers? An overlooked NMR solution D.X. Hu, P. Grice, S.V. Ley, J. Org. Chem. 2012, 77, 5198-5202.
741. The continuous flow processing of gaseous ammonia using a Teflon AF-2400 tube in tube reactor: the synthesis of thioureas and in-line titrations D.L. Browne, M. O’Brien, P. Koos, P.B. Cranwell, A. Polyzos, S.V. Ley, Synlett 2012, 1402-1406.
740. Continuous preparation of arylmagnesium reagents in flow with in-line IR monitoring T. Brodmann, P. Koos, A. Metzger, P. Knochel, S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 1102-1113.
739. A flow based synthesis of 2-aminoadamantane-2-carboyxlic acid C. Battilocchio, I.R. Baxendale, M. Biava, M.O. Kitching and S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 798-810.
738. A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazolesT.M. Beale, D.M. Allwood, A. Bender, P.J. Bond, J.D. Brenton, D.S. Charnock-Jones, S.V. Ley, R.M. Myers*, J.W. Shearman, J. Temple, J. Unger, C.A. Watts, J. Xian, ACS Med. Chem. Lett. 2012, 3, 177-181.
737. Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A1 T.M. Beale, P.J. Bond, J.D. Brenton, D.S.Charnock-Jones, S.V. Ley, R.M. Myers*, Bioorg. Med. Chem. 2012, 20, 1749-1759.
736. The oxygen mediated continuous flow synthesis of 1,3-butadiynes using Teflon AF-2400 to effect gas-liquid contact T.P. Peterson, A. Polyzos, M. O’Brien, T. Ulven, I.R. Baxendale, S.V. Ley, Chem. Sus. Chem. 2012, 5, 274-277.
735. A total synthesis of millingtonine A J. Wegner, S.V. Ley, A. Kirschning, A-L. Hansen, J. Montenegro Garcia, I.R. Baxendale, Org. Lett. 2012, 14, 696-699.
734. Scale-up of flow assisted synthesis of C2-symmetric chiral PyBox-ligands C. Battilocchio, M. Baumann, I.R. Baxendale, M. Biava, M.O. Kitching, S.V. Ley, R.M. Martin*, S.A. Ohnmacht, N.D.C. Tappin, Synthesis 2012, 44, 635-647.
733. Continuous stream processing: a prototype magnetic field induced flow mixer P. Koos, D.L. Browne, S.V. Ley, Green Process. and Synth. 2012, 1, 11-18.
732. Twenty Five Years of Azadirachtins (1986-2011), H.E. Hummel, D.F. Hein, S.V. Ley, E.D. Morgan, W. Kraus, H. Schmutterer, Pesticides, 2011, 1-4, 49-56.
731. The application of a monolithic triphenylphospine reagent for conducting Appel reactions in flow microreactors K. Roper, H. Lange, A. Polyzos, M.B. Berry, I.R. Baxendale, S.V. Ley, Bielstein J. Org. Chem. 2011, 7, 1648-1655.
730. Piecing together the puzzle: understanding a mild, metal free reduction method for large scale synthesis of hydrazines D.L. Browne,* I.R. Baxendale, S.V. Ley, Tetrahedron 2011, 67, 10296-10303.
729. Syngas mediated C-C bond formation in flow: selective rhodium catalysed hydroformylation of styrenes S. Kasinathan, S.L. Bourne, P. Tolstoy, P. Koos, M. O’Brien, R.W. Bates, I.R. Baxendale, S.V. Ley, Synlett 2011, 2648-2651.
728. The continuous-flow Synthesis of styrenes using ethylene in a palladium catalysed Heck cross-coupling reaction S.L. Bourne, P. Koos, M. O’Brien, B. Martin, B. Schenkel, I.R. Baxendale, S.V. Ley, Synlett 2011, 2643-2647.
727. Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO Concentration P. Koos, U. Gross, A. Polyzos, M. O’Brien, I.R. Baxendale, S.V. Ley, Org. Biomol. Chem. 2011, 9, 6903-6908.
726. Piperazic acid-containing natural products: isolation, biological relevance and total synthesis A.J. Oelke, D.J. France, T. Hofmann, G. Wiutschik, S.V. Ley, Nat. Prod. Rep., 2011, 28, 1445-1471.
725. The flow synthesis of heterocycles for natural products and medicinal chemistry applications M. Baumann, I.R. Baxendale, S.V. Ley, Mol. Div. 2011, 15, 613-630.
724. Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods M. Baumann, R.E. Martin, C. Kuratli, J. Schneider, I.R. Baxendale, S.V. Ley, A.C.S. Comb. Sci. 2011, 13, 405-413.
723. A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures D.L. Browne, M. Baumann, B.H. Harji, I.R. Baxendale, S.V. Ley, Org. Lett. 2011, 13, 3312-3315.
722. The clerodane ring system: investigating the viability of a direct Diels-Alder approach A.T. Merritt, R.H. Pouwer, D.J. Williams, C.M. Williams, S.V. Ley Org. Biomol. Chem. 2011, 9, 4745-4747.
721. Hydrogenation in flow: homogenous and heterogeneous catalysts using Teflon AF-2400 to effect gas-liquid contact at elevated pressure M. O’Brien, N. Taylor, A. Polyzos, I.R. Baxendale, S.V. Ley Chem. Sci. 2011, 2, 1250-1257.
720. An integrated flow and batch-based approach for the synthesis of O-methyl siphonazole M. Baumann, I.R. Baxendale, M. Brasholz, J.J. Hayward, S.V. Ley, N. Nikbin Synlett 2011, 10, 1375-1380
719. Retinoic acid receptor signalling regulates choroid tissue closure through independent mechanisms in the ventral optic cup and periocular mesenchyme G. Lupo, G. Gestri, M. O’Brien, R.M. Denton, R.A. Chandraratna, S.V. Ley, W.A. Harris, S.W. Wilson, Proc. Natl. Acad. Sci. 2011, 108, 8698-8703.
718. Continuous flow processing of slurries: evaluation of an agitated cell reactor D.L. Browne, B.J. Deadman, R. Ashe, I.R. Baxendale, S.V. Ley, Org. Proc. Res. Dev. 2011, 15, 693-697.
717. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins X. Qi, F. Loiseau, W.L. Chan, Y. Yan, Z. Wei, L-G. Milroy, R.M. Myers, S.V. Ley, R.J. Read, R.W. Carrell, A. Zhou,* J. Biol. Chem. 2011, 286, 16163-16173.
716. An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin, Beilstein J. Org. Chem. 2011, 7, 442-495.
715. Less well Known enabling technologies for organic synthesis M. O’Brien, R. Denton, S.V. Ley, Synthesis 2011, 1157-1192.
714. Total synthesis of chloptosin: a dimeric cyclohexapeptide A.J. Oelke, F. Antonietti, L. Bertone, P.B. Cranwell, D.J. France, R.J.M. Goss, T. Hoffman, S. Knauer, S.J. Moss, P.C. Skelton, R.M. Turner, G. Wuitschik, S.V. Ley, Chem. Eur. J. 2011, 17, 4183-4194.
713. Oxidation reactions in segmented and continuous flow chemical processing using a N-(tert Butyl)phenylsulfinimidoyl chloride monolith H. Lange, M.J. Carpenter, A.X. Jones, C.J. Smith, N. Nikbin, I.R. Baxendale, S.V. Ley, Synlett 2011, 6, 869-873.
712.A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing H. Lange, C.F. Carter, M.D. Hopkin, A. Burke, J.G. Goode, I.R. Baxendale, S.V. Ley, Chem. Sci. 2011, 2, 765-769.
711. Diastereoselective chain elongation reactions using microreactors for application in complex molecule assembly C.F. Carter, H. Lange, D. Sakai, I.R. Baxendale, S.V. Ley, Chem. Eur. J., 2011, 17, 3398-3405.
710. A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles C.J. Smith, N. Nikbin, S.V. Ley, H. Lange, I.R. Baxendale, Org. Biomol. Chem., 2011, 9, 1938-1947.
709. Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent C.J. Smith, C.D. Smith, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2011, 9, 1927-1937.
708. The continuous flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor A. Polyzos, M. O’Brien, T. Pugaard-Petersen, I.R. Baxendale, S.V. Ley, Angew. Chem. Int. Ed. 2011, 50, 1190-1193.
707. Lab of the future: the importance of remote monitoring and control M.D. Hopkin, I.R. Baxendale, S.V. Ley, Chim. Oggi./Chemistry Today, 2011, 29, 28-32.
706. Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor L. J. Martin, A.L. Marzinzik, S.V. Ley, I.R. Baxendale, Org. Lett. 2011, 13, 320-323.
705. Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties A. Francais, A. Leyva-Pérez, G. Etxebarria-Jardi, J. Peña, S.V. Ley, Chem. Eur. J. 2011, 17, 329-343.
704. Total synthesis of subereomollines A and B J.W. Shearman, R. M. Myers, J.D. Brenton, S.V. Ley, Org. Biomol. Chem. 2011, 9, 62-65.
703. Microwave and flow syntheses of Pseudomonas Quinolone Signal (PQS) and analogues J.T. Hodgkinson, W.R.J.D. Galloway, S. Saraf, I.R. Baxendale, S.V. Ley, M. Ladlow, M. Welch, D.R. Spring, Org. Biomol. Chem. 2011, 9, 57-61.
702. Synthesis of highly substituted 3-nitropyrrolidines and 3-nitropyrroles by a multicomponent multi-step flow sequence M. Baumann, I.R. Baxendale, J. Wegner, A. Kirschning, S.V. Ley, Heterocycles2010, 82, 1297-1316.
701. Trapping of novel palindromic ligands within native transthyretin prevents amyloid formation S.E. Kolstoe, P.P. Mangione, V. Bellotti, G.W. Taylor, G.A. Tennent, S. Deroe, A.J. Morrison, A.J. Cobb, A. Coyne, M.G. McCammon, R. Gill, M.P. Smith, S.V. Ley, C.V. Robinson, S.P. Wood, M.B. Pepys, Proc. Nat. .Acad. Sci. 2010, 107, 20483-20488.
700. A continuous flow process using a sequence of microreactors with in-line IR analysis of the preparation of N, N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl) benzamide as a potent and highly selective δ-opioid receptor agonist Z. Qian, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2010, 16, 12342-12348.
699. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor L. Malet-Sanz, J. Madrzak, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 5324-5332.
698. Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4 T.M. Beale, R.M. Myers, J.W. Shearman, D.S. Charnock-Jones, J.D. Brenton, F.V. Gergeley, S.V. Ley, Med. Chem. Commun. 2010, 1, 202-208.
697. Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 J.W. Shearman, R.M. Myers, T.M. Beale, J.D. Brenton, S.V. Ley, Tetrahedron Lett. 2010, 51, 4812-4814.
696. Total synthesis of chloptosin A.J. Oelke, D.J. France, T. Hofmann, G. Wuitschik, S.V. Ley, Angew. Chem. Int. Ed. 2010, 49, 6139-6142
695. KMnO4 mediated oxidation as a continuous flow process J. Sedelmeier, S.V. Ley, I.R. Baxendale, M. Baumann, Org. Lett., 2010, 12, 3618-3621.
694. Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes F. Tozzi, S.V.Ley, M.O. Kitching, I.R. Baxendale, Synlett 2010, 13, 1919-1922.
693. A palladium wall coated microcapillary reactor for use in continuous flow transfer hydrogenation C.H. Hornung, B. Hallmark, M.R. Mackley, I.R. Baxendale, S.V. Ley, Adv. Synth. Catal. 2010, 352, 1736-1745.
692. The changing face of organic synthesis S.V. Ley, Tetrahedron 2010, 66, 6270-6292.
691. Electronic encyclopaedia of reagents in organic synthesis Ed. L.A. Paquette. Magnesium Nitrideby K. Bridgwood, S.V. Ley, DOI: 10.1002/047084289X.rn01264.
690. Multiple microcapillary reactor for organic synthesis C.H. Hornung, B. Hallmark, M. Baumann, I.R. Baxendale, S.V. Ley, P. Hester, P. Clayton, M.R. Mackley, Ind. Eng. Chem. Res. 2010,49, 4576-4582.
689. Application of flow chemistry microreactors in the preparation of casein kinase I inhibitors F. Venturoni, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 1798-1806.
688. Flow ozonolysis using a semi-permeable Teflon™ AF-2400 membrane to effect gas-liquid contact M. O’Brien, I.R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 1596-1598.
687. An automated flow-based synthesis of imatinib: the API of gleevec M.D. Hopkin, I.R. Baxendale, S.V. Ley, J.C.S. Chem. Commun. 2010, 46, 2450-2452.
686. ReactIR™ flow cell: a new analytical tool for continuous flow chemistry processing C.F. Carter, H. Lange, I.R. Baxendale, S.V. Ley, J. Goode, N. Gaunt, B. Wittkamp, Org. Proc. Res. Dev. 2010, 14, 393-404.
685. The continuous flow synthesis of butane 2,3-diacetal protected building blocks using microreactors C.F. Carter, I.R. Baxendale, J.B.J. Pavey, S.V. Ley, Org. Biomol. Chem. 2010, 8, 1588-1595.
684. Synthesis of nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor M. Baumann, I.R. Baxendale, S.V. Ley, Synlett 2010, 749-752.
683. A flowprocess using microreactors for the preparation of a quinolone derivative as a potent 5HTIB antagonist Z. Qian, I. R. Baxendale, S.V. Ley, Synlett, 2010, 505-508.
682. Total synthesis of the anti-apoptotic agents Iso- and bongkrekic acids A. Francais, A. Leyva, G. Etxebarria-Jardi, I. R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 340-343.
681. Multi-step synthesis using modular flow reactors: the preparation of yne-ones and their use in heterocycle synthesis I.R. Baxendale, S.C. Schou, J. Sedelmeier, S.V. Ley, Chem. Eur. J. 2010, 16, 89-94.
680. An asymmetric tandem conjugative addition-intramolecular cyclisation process to provide functionalised 3,6-dihydropyrans and 4,5-epoxytetrahydropyrans S. Catalán-Munoz, C.A. Müller, S.V. Ley, Eur. J. Org, Chem. 2010, 183-190.
2009-2000
679. Total Synthesis of (-)Spirangien A and the Corresponding Methyl Ester Commentary by P.B. Cranwell, S.V. Ley, Chemtracts 2009, 22, 173-181.
678. Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane 2, 3- Diacetal Tartrates C.F. Carter, I.R. Baxendale, M. O’Brien, J.B.J. Pavey, S.V. Ley, Org. Biomol. Chem. 2009, 7, 4594.
677. Enantioselective Synthesis of the Lyngbouilloside Macrolactone Core D. Webb, A. van den Heuval, M. Kögl, S.V. Ley, Synlett 2009, 14, 2320-2324.
676. Pd-EnCat™ TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-substituted Acetylenes via Microwave Assisted Sonogashira type Reactions J. Sedelmeier, S.V. Ley, H. Lange, I.R. Baxendale, Eur. J. Org. Chem. 2009, 4412-4420.
675. Cancer, Chemistry, and the Cell: Molecules that Interact with the Neurotensin ReceptorsR.M. Myers,* J.W. Shearman, M.O. Kitching, A. Ramos-Montoya, D.E. Neal, S.V. Ley, ACS Chem. Biol. 2009, 4, 503-525.
674. Development of Fluorination Methods using Continuous-Flow Microreactors M. Baumann, I.R. Baxendale, L.J. Martin, S.V. Ley, Tetrahedron 2009, 65, 6611-6625.
673. Methyliminoacetic Acid (MIDA) Boronates: A New Strategy for Organic Synthesis Commentary C.F. Carter and S.V. Ley, Chemtracts 2009, 21, 457-465.
672. Total Synthesis of the Potent Antifungal Agents Bengazole C and E A. Enríquez-Garcia and S.V. Ley, Coll. Czech. Chem. Comm. 2009, 74, 887-900.
671. Continuous Flow Based Catch and Release Protocol for the Synthesis of alpha-Ketoesters A. Palmieri, S.V. Ley, A. Polyzos, M. Ladlow and I.R. Baxendale, Beilstein J. Org. Chem. 2009, 5, No. 23.
670. A Microfluidic Flow Chemistry Platform for Organic Synthesis: the Hofmann Rearrangement A. Palmieri, S.V. Ley, K. Hammond, A. Polyzos and I.R. Baxendale, Tetrahedron Lett. 2009, 50, 3287-3289.
669. MultiStep Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles I.R. Baxendale, S.V. Ley, A.C. Mansfield, C.D. Smith, Angew. Chem. Int. Ed. 2009, 48, 4017-4021.
668. An Efficient and Transition Metal Free Protocol for the Transfer Hydrogenation of Ketones as a Continuous Flow Process J. Sedelmeier, I.R. Baxendale and S.V. Ley, Green Chem. 2009, 11, 683-685.
667. A Base-Catalysed, One Pot, Three Component Coupling Reaction Leading to Nitrosubstituted Pyrroles I.R. Baxendale, C.D. Buckle, S.V. Ley, L. Tamborini, Synthesis, 2009, 9, 1485-1493.
666. AuCl3-Catalysed Hydroalkoxylation of Conjugated Alkynoates: Synthesis of Five and Six-Membered Cyclic Acetals A. Diéguez-Vázquez, C.C. Tzschucke, J. Crecente-Campo, S. McGrath, S.V. Ley, Eur. J. Org. Chem, 2009, 40, 1698-1706.
665. New Tools for Molecule Makers: Emerging Technologies S.V. Ley and I.R. Baxendale. Eds. M. Hicks and C. Kettner. Proc. of the Beilstien Symposium on Systems Chemistry, Bozen, Italy ISBN 978-8325-2188-2, 2009, 65-85.
664. Total Synthesis of Rapamycin S.V. Ley, M.N. Tackett, M.L. Maddess, J.C. Anderson, P.E. Brennan, M.W. Cappi, J.P. Heer, C. Helgen, M. Kori, C. Kouklovsky, S.P. Marsden, J. Norman, D.P. Osborn, M.Á. Palomero, J.B.J. Pavey, C. Pinel, L.A. Robinson, J. Schnaubelt, J.S. Scott, C.D. Spilling, H. Watanabe, K.E. Wesson and M.C. Willis, Chem. Eur. J., 2009, 15, 2874-2914. (https://doi.org/10.1002/chem.200801656).
663. Highly Diastereoselective Desymmetrisation of Cyclic Meso-Anhydrides and Derivatisation for use in Natural Product Syntheses A.C. Evans, D.A. Longbottom, M. Matsuoka, R.M. Turner, V. Frankevicvius, S.V. Ley, Org. Biomol. Chem., 2009, 7, 747-760.
662. Second-Generation Synthesis of Azadirachtin : A Concise Preparation of the Propargylic Mesylate Fragment A. Boyer, G.E. Veitch, E. Beckmann and S.V. Ley, Angew. Chem. Int. Edn., 2009, 48, 1317-1320.
661. Natural product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukemia L-G Milroy, G. Zinzalla, F. Loiseau, Z. Qian, G. Prencipe, C. Pepper and S.V. Ley Chem. Med. Chem., 2008, 3, 1922-1935.
660. The Azadirachtin Story G.E. Veitch, A. Boyer and S.V. Ley, Angew. Chem. Int. Ed., 2008, 47, 9402-9429.
659. The Synthesis of Azadirachtin: A Potent Insect Antifeedant S.V. Ley, A. Abad-Somovila, J.C. Anderson, C. Ayats, R. Bänteli, E. Beckmann, A. Boyer, M.G. Brasca, A. Brice, H. Broughton, B.J. Burke, E. Cleator, D. Craig, A.A. Denholm, T. Durand-Reville, L.B. Gobbi, M. Gröbel, B.L. Gray, R.B. Grossmann, C.E. Gutteridge, N. Hahn, S.L. Harding, D.C. Jennens, P.J. Lovell, H.J. Lovell, M.L. de la Puente, H.C. Kolb, W-J Koot, S.L. Maslen, C.F. McCusker, A. Mattes, A.R. Pape, A. Pinto, D. Santfianos, J.S. Scott, S.C. Smith, A.Q. Somers, C.D. Spilling, F. Stelzer, P.L. Toogood, R.M. Turner, G.E. Veitch, A. Wood, C. Zumbrunn, Chem. Eur. J., 2008, 14, 10683-10704.
658. A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor I.R. Baxendale, S.V. Ley, C.D. Smith, L. Tamborini and A.F. Voica, J. Combinatorial Chem., 2008, 10, 851-857.
657. Magnesium Nitride as a Convenient Source of Ammonia for the Paarl-Knorr Preparation of Pyrroles G.E. Veitch, K.L. Bridgwood, K. Rands-Trevor and S.V. Ley, Synlett, 2008, 17, 2597-2600.
656. Enantiopure 2-Substituted Glyceraldehyde Derivatives by Aza-Claisen Rearrangement or C-Alkylation of Enamines K.L. Bridgwood, C.C. Tzschucke, M.O’Brien, S. Wittrock, J.M. Goodman, J.E. Davies, A.W.J. Logan, M.R.M. Hüttl, and S.V. Ley, Org. Lett., 2008, 10, 4537-4540.
655. The Use of Diethylaminosulfur-Trifluoride (DAST) for the Fluorination in a Continuous Flow Reactor M. Baumann, I.R. Baxendale and S.V. Ley, Synlett, 2008, 14, 2111-2114.
654. Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Dihydropyridines K.L. Bridgwood, G.E. Veitch, and S.V. Ley, Org. Lett. 2008, 10, 3627-3629.
653. Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides G.E. Veitch, K.L. Bridgwood and S.V. Ley, Org. Lett. 2008, 10, 3623-3625.
652. New Opportunities for Advancing Organic Synthesis and Flow Based Chemical Processing M. Baumann, I.R. Baxendale, J.J. Hayward, M.D. Hopkin, J. Jin, M.O. Kitching, S. Lanners, S.V. Ley, N. Nikbin-Rousardi, C.D. Smith, C.J. Smith and L. Tamborini, J. Labelled Compd. and Pharmaceuticals 2008, 51, 252-253.
651. A General Organocatalytic Enantioselective Malonate Addition to α,β-Unsaturated Enones V. Wascholowski, K.R. Knudsen, C.E.T. Mitchell and S.V. Ley, Chem. Eur. J., 2008, 14, 6155-6165.
650. FeCl3 Catalysed Cleavage of 2,3-Butanediacetal Protected Diols
C.C. Tzschucke, N. Pradidphol, A. Dieguez-Vazquez, B. Kongkathip, N. Kongkathip and S.V. Ley, Synlett, 2008, 9, 1293-1296.
649. A New Focussed Microwave Approach to the Synthesis of Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-Component Coupling Process M.D. Hopkin, I.R. Baxendale and S.V. Ley, Synthesis, 2008, 1688-1702.
648. A New Synthesis of (-)-Epipyriculol: a Phytotoxic Metabolite A. Levya, F.E. Blum and S.V. Ley, Tetrahedron, 2008, 64, 4711-4717.
647. Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin and C.D. Smith, Org. Biomol. Chem. 2008, 6, 1587-1593.
646. A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin, C.D. Smith and J.P. Tierney, Org. Biomol. Chem. 2008, 6, 1577-1586.
645. A General Organocatalytic Enantioselective Nitrocyclopropanation Reaction V. Wascholowski, H.M. Hansen, D.A. Longbottom and S.V. Ley, Synthesis, 2008, 8, 1269-1275.
644. The Changing Face of Organic Synthesis S.V. Ley and I.R. Baxendale, Chimia, 2008, 62, 162-168.
643. Organic Chemistry in Microreactors; Heterogenous Reactions I.R. Baxendale, J.J. Hayward, S. Lanners, S.V. Ley, C.D. Smith. “Microreactors in Organic Chemistry and Catalysis” ed. T. Wirth and J. Wiley. Print ISBN:9783527318698 |Online ISBN:9783527622856 |DOI:10.1002/9783527622856
642. Azeotropic Reflux Chromatography: An Efficient Solution to a Difficult Separation in the Scale-up of Spongistatin I M. O’Brien, A. Dieguez-Vázquez, D-S. Hsu, H. Kraus, Y. Sumino and S.V. Ley, Org. Biomol. Chem., 2008, 6, 1159-1164.
641. Total Synthesis Studies Towards the Macrocyclic Pipercolic Natural Products FK 506, Antascomycins and Rapamycin M.L. Maddess, M.N. Tackett and S.V. Ley, “Progress in Drug Research Vol 66: Natural Compounds as Drugs, Vol. II Eds. F. Peterson and R. Amstutz, 2008, Birkhauser Verlag AG Basel ISBN:978-3-7643-8594. P13-186.
640. Facile, One-Step Production of Niacin (Vitamin B3) and other Nitrogen-Containing Pharmaceutical Chemicals with a Single-Site Heterogeneous Catalyst R. Raja. J.M. Thomas, M. Greenhill-Hooper, S.V. Ley, and F.A. Almeida Paz, Chem. Eu. J., 2008, 14, 2340-2348.
639. Synthesis of Natural Products from the Indian Neem Tree Azadirachta indica G.E. Veitch, A. Pinto, A. Boyer, E. Beckmann, J.C. Anderson and S.V. Ley, Org. Lett., 2008, 10, 569-572.
638. Practical Organocatalysis with (S)- and (R)-5 Pyrrolidin-2-yl-1H-tetrazoles D.A. Longbottom, V. Frankevicivus, S. Kumarn, A.J. Oelke, V. Wascholowski and S.V. Ley, Aldrichimica Acta, 2008, 41, 3.
637. Functionalised Butanediacetal Protected 1,2-Diols as Suitable Substrates for Pd- Catalysed Cross Coupling Reactions A. Levya, F.E. Blum, P.R. Hewitt and S.V. Ley, Tetrahedron, 2008, 64, 2348-2358.
636. Synthesis of (S)-5-Pyrrolidin-2-yl-1H-Tetrazole V. Aureggi, V. Frankevicvius, M.O. Kitching, S.V. Ley, D.A. Longbottom, A.J. Oelke and G. Sedelmeier, Org. Synth. 2008, 85, 72-87.
635. PtCl4 Catalysed Domino Synthesis of Fused Bicyclic Acetals A. Diéguez-Vázquez, C.C. Tzschucke, Wing-Ye Lam and S.V. Ley, Angew. Chem. Int. Ed., 2008, 47, 209-212.
634. Microwave Reactions Under Continuous Flow Conditions I.R. Baxendale, J.J. Hayward and S.V. Ley, Comb. Chem. High T.Scr. 2007, 10, 802-836.
633. A New Relay Route for the Synthesis of Azadirachtin G.E. Veitch, E. Beckmann, B. J. Burke, A. Boyer, C. Ayats and S.V. Ley, Angew. Chem., Int. Ed. 2007, 46, 7633-7635.
632. Synthesis of Azadirachtin: A Long but Successful Journey, G.E. Veitch, E. Beckmann, B.J. Burke, A. Boyer, S.L. Maslen and S.V. Ley, Angew. Chem. Int. Ed. 2007, 46, 7629-7632.
631. Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools, S.V. Ley, I.R. Baxendale, D.A. Longbottom and R.M. Myers. Ed. M.S. Chorghade Book Chapter from “Drug Discovery & Development”, Vol. 2 Drug Development. John Wiley & Sons 2007. ISBN: 0-471-39847-9, p51-89.
630. Chiral Glycolate Equivalents for the Asymmetric Synthesis of alpha-Hydroxycarbonyl Compounds S.V. Ley, T.D. Sheppard, R.M. Myers and M.S. Chorghade, Bull. Chem. Soc. Jpn. 2007, 80, 1451-1472.
629. Flow and Batch Mode Focused Microwave Synthesis of 5-Amino-4-cyanopyrazoles and their further conversion to 4-Aminopyrazolopyrimidines C.J. Smith, J. Iglesias-Sigüenza, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem. 2007, 5, 2758-2761.
628. A Sequential Enantioselective Organocatalytic Route to Chiral 1,2-Oxazines and Chiral Pyridazines S. Kumarn, A.J. Oelke, D.M. Shaw, D.A. Longbottom and S.V. Ley, Org. Biomol. Chem., 2007, 5, 2678-2689.
627. Electronic Encyclopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, (E)-3-Iodoprop-2-enoic Acid; (Z)- Isomer, S.V. Ley and D.A. Longbottom, DOI: 10.1002/047084289X.rn00815.
626. A Fascination with 1,2-Diacetals S.V. Ley and A. Polara, J. Org. Chem., 2007, 72, 5943-5959.
625. Solid Supported Reagents in Multi-Step Flow Synthesis I.R. Baxendale and S.V. Ley, “New Avenues to Efficient Chemical Synthesis: Emerging Technologies”, Symposium Proceeding 06.3, Ed: P.H. Seeberger and T. Blume. Springer, Berlin Heidelberg, ISBN 978-3-540-70848-3, 2007, 3, 151-185.
624. Total Synthesis of Five Thapsigargins – Guaianolide Natural Products Exhibiting Subnanomolar SERCA Inhibition S.P. Andrews, M. Ball, F. Wierschem, E. Cleator, S. Oliver, K. Högenauer, O. Simic, A. Antonello, U. Hünger, M.D. Smith and S.V. Ley, Chem. Eur. J., 2007, 13, 5688-5712.
623. Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A and B J.A. Bull, E.P. Balskus, R.A.J. Horan, M. Langner and S.V. Ley, Chem. Eur. J. 2007, 13, 5515-5538.
622. Science of Synthesis, Compounds with Two Carbon-Heteroatom Bonds, Vol. Ed. S.L. Warriner, Vol. 29, Product Class 9: Spiroketals, S.V. Ley, L-G. Milroy and R.M. Myers. Thieme-Verlag, Stuttgart, Germany, 2007 p 613-689.
621. Pharmaceutical Strategy and Innovation: An Academic’s Perspective, I.R. Baxendale, J.J. Hayward, S.V. Ley and G.K. Tranmer, Chem. Med. Chem., 2007, 2, 768-788.
620. (S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric Organocatalysts of Broad Utility in Organic Synthesis D.A. Longbottom, V. Franckevicvius
and S.V. Ley, Chimia, 2007, 61, 247-256.
619. Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd[0] Nanoclusters N. Nikbin, M. Ladlow, S.V. Ley, Org. Proc. Res. Dev., 2007, 11, 458-462.
618. A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis, C.H. Hornung, M.R. Mackley, I.R. Baxendale and S.V. Ley and, Org. Proc. Res. Dev., 2007, 11, 399-405.
617. A Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System C.M. Griffiths-Jones, M.D. Hopkin, D. Jönssen, S.V. Ley, D.J. Tapolczay, E. Vickerstaffe and M. Ladlow, J. Comb. Chem. 2007, 9, 422-430.
616. Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process C.D. Smith, I.R. Baxendale, G.K. Tranmer, M. Baumann, S.C. Smith, R.A. Lewthwaite and S.V. Ley, Org. Biomol. Chem., 2007, 5, 1562-1568.
615. [3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3- Triazoles in a Modular Flow Reactor C.D. Smith, I.R. Baxendale, S. Lanners, J.J. Hayward, S.C. Smith and S.V. Ley, Org. Biomol. Chem. 2007, 5, 1559-1561.
614. Chromatography-Free Suzuki Reactions using a Polymer-Assisted Solution-Phase (PASP) Approach E. Vickerstaffe, A-L. Villard, M. Ladlow and S.V. Ley, Synlett, 2007, 1251-1254.
613. Design and Total Synthesis of Unnatural Analogues of the Sub-Nanomolar SERCA Inhibitor Thapsigargin S.P. Andrews, M. Tait, M. Ball and S.V. Ley, Org. Biomol. Chem. 2007, 5, 1427-1436.
612. Identification of a Putitive Azadirachtin-Binding Complex from Drosophila Kc167 Cells S.L. Robertson, W. Ni, T.S. Dhadialla, A.J. Nisbet, C. McCusker, S.V. Ley, W. Mordue and A.J. Mordue, Arch. Insect. Biochem. and Physiol. 2007, 64, 200-208.
611. Optimisation of Conditions for O-Benzyl and N-Benzyloxycarbonyl Protecting Group Removal using an Automated Flow Hydrogenator K.R. Knudsen, J. Holden, S.V. Ley and M. Ladlow, Adv. Syn. Cat. 2007, 349, 535-538.
610. Chemical Variation of Natural Product-Like Scaffolds: Design, Synthesis and Biological Activity of Fused Bicyclic Acetal Derivatives L-G Milroy, G. Zinzalla, G. Prencipe, P. Michel, S.V. Ley, M. Gunaratnam, M. Beltran and S. Neidle, Angew. Chem. Int. Ed. 2007, 46, 2493-2496.
609. Total Synthesis of Thapsigargin, A Potent SERCA Pump Inhibitor M. Ball, S.P. Andrews, F. Wierschem, E. Cleator, M.D. Smith and S.V. Ley, Org. Lett. 2007, 9, 663-666.
608. Total Synthesis of Rapamycin M.L. Maddess, M.N. Tackett, H. Watanabe, P.E. Brennan, C.D. Spilling, J.S. Scott, D.P. Osborn and S.V. Ley, Angew. Chem., Int. Ed. 2007, 46, 591-597. (https:dx.doi.org 10.1002/anie.200604053)
607. Polymer-Supported Reagents and Scavengers in Synthesis S.V. Ley, I.R. Baxendale and R.M. Myers, in “Comprehensive Medicinal Chemistry II, Vol.3, Drug Discovery Technologies. Eds. D.J. Triggle and J.B. Taylor, Elsevier, Oxford, 2006, 791-836. ISBN: 0080445136.
606. A New Asymmetric Organocatalytic Nitrocyclopropanation Reaction H.M. Hansen, D.A. Longbottom and S.V. Ley, J. Chem. Soc., Chem. Commun. 2006, 4838-4840.
605. A Flow Reactor Process for the Synthesis of Peptides Utilizing Immobilised Reagents, Scavengers and Catch and Release Protocols, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, J. Chem. Soc., Chem. Commun. 2006, 4835-4837.
604. A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles M. Baumann, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, Org. Lett. 2006, 8, 5231-5234.
603. Asymmetric Organocatalysis S.V. Ley, in “Asymmetric Synthesis – The Essentials”. M. Christmann and Ed. S. Bräse. Wiley-VCH. 2006 ISBN-978-3-527-31399-0, 211-216.
602. Stereocontrolled Total Synthesis of Bengazole A: A Marine Bisoxazole Natural Product Displaying Potent Antifungal Properties J.A. Bull, E.P. Balskus, R.A.J. Horan, M. Langner and S.V. Ley, Angew. Chem. Int. Ed. 2006, 45, 6714-6718.
601. An Enantioselective Organocatalytic Route to Chiral 3,6-Dihydropyridazines from Aldehydes A.J. Oelke, S. Kumarn, D.A. Longbottom, S.V. Ley, Synlett, 2006, 2548-2552.
600. 8,9,10,10a-Tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazines: New Heterocyclic Structures Generated by an Ugi-Type Three Component Reaction V. Franckevicvius, D.A. Longbottom, R.M. Turner and S.V. Ley, Synthesis 2006, 3215-3223.
599. Enantioselective Catalytic Intramolecular Cyclopropanation using Modified Cinchona Alkaloid Organocatalysts C.C.C. Johansson, N. Bremeyer, S.V. Ley, D.R. Owen, S.C. Smith and M.J. Gaunt, Angew. Chem., Int. Ed. 2006, 45, 6024-6028.
598. Hydrogenation of Aromatic Ketones, Aldehydes and Epoxides with Hydrogen and Pd(0) EnCatTM 30NP R.H. Perni, S.V. Ley, A.J.P. Steward-Liddon, D. Pears and K. Treacher, Beilstein J. Org. Chem. 2006, 2, 15.
597. A Highly Selective, Organocatalytic Route to Chiral 1,2-Oxazines from Ketones S. Kumarn, D.M. Shaw and S.V. Ley, J. Chem. Soc., Chem. Commun. 2006, 3211-3213.
596. The Use of Polymer Supported Reagents and Scavengers in the Synthesis of Natural Products S.V. Ley, I.R. Baxendale and R.M. Myers, in “Combinatorial Synthesis of Natural Product-Based Libraries”, Ed. A.M. Boldi, CRC Press, Boca-Raton, Florida, USA, 2006. ISBN 0-8493-4000-4. Ch. 6; 131-163.
595. A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly I.R. Baxendale, J. Deeley, C.M. Griffiths-Jones, S.V. Ley, S. Saaby and G. Tranmer, J. Chem. Soc., Chem. Commun. 2006, 2566-2568.
594. Targeting C-Reactive Protein for the Treatment of Human Cardiovascular Disease M.B. Pepys, G.M. Hirschfield, G.A. Tennent, J.R. Gallimore, M.C. Kahan, V. Bellotti, P.N. Hawkins, R.M. Myers, M.D. Smith, A. Polara, A.J.A. Cobb, S.V. Ley, J.A. Aquillina, C.V. Robinson, I. Sharif, G.A. Gray, C.A. Sabin, M.C. Jenvey, S.E. Kolstoe, D. Thompson and S.P. Wood, Nature 2006, 440, 1217-1221.
593. Microwave Assisted Suzuki Coupling Reactions with an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations I.R. Baxendale, C.M. Griffiths-Jones, S.V. Ley and G. Tranmer, Chem. Eur. J. 2006, 12, 4407-4416.
592. An Efficient, Asymmetric Organocatalyst-mediated Conjugate Addition of Nitroalkanes to Unsaturated Cyclic and Acyclic Systems C.E.T. Mitchell, S.E. Brenner, J. Garcia-Fortanet and S.V. Ley, Org. Biomol. Chem. 2006, 4, 2039-2049.
591. Chemical Variation of Natural Product-Like Scaffolds: Design and Synthesis of Spiroketal Derivatives G. Zinzalla, L-G. Milroy and S.V. Ley, Org. Biomol. Chem. 2006, 4, 1977-2002.
590. A Highly Enantioselective Total Synthesis of (+)-Goniodiol E.W. Tate, D.J. Dixon and S.V. Ley, Org. Biomol. Chem. 2006, 4, 1698-1706.
589. Diastereoselective Aldol Reactions with Butane 2,3-diacetal Protected Glyceraldehyde Derivatives K. Rahbek Knudsen, A.F. Stepan, P. Michel and S.V. Ley, Org. Biomol. Chem. 2006, 4, 1471-1473.
588. The Use of Polymer-Assisted Solution-Phase Synthesis and Automation for High Throughput Preparation of Biologically Active Materials S.V. Ley, M. Ladlow and E. Vickerstaffe, “Exploring Chemical Diversity for Drug Discovery”, Ed. P.A. Bartlett and M. Entzeroth, Royal Society of Chemistry, UK, 2006. ISBN-10:0-85404-842-1, p3-32.
587. Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems to Generate Protected 1,3-Dicarbonyl Compounds H.F. Sneddon, A. van den Heuvel, D.M. Shaw, M.J. Gaunt, A. Hirsh, R. Booth and S.V. Ley, J. Org. Chem. 2006, 71, 2715-2725.
586. Practical Synthesis of (S)-Pyrrolidin-2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal by Flow-reactor Hydrogenolysis V. Franckevicius, K.R. Knudsen, M. Ladlow, D.A. Longbottom and S.V. Ley, Synlett, 2006, 889-892.
585. Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process I.R. Baxendale, C.M. Griffiths-Jones, S.V. Ley and G.K. Tranmer, Synlett 2006, 427-430.
584. Asymmetric Organocatalytic Conjugate Addition of Malonates to Enones Using a Proline Tetrazole C.E.T. Mitchell, K.R. Knudsen, C.E.T. Mitchell and S.V. Ley, J. Chem. Soc. Chem. Commum. 2006, 66-68.
583. Evolution or Revolution: The Challenge to Today’s Medicinal Chemist S.V. Ley and R.M. Myers, “The Chemical Theatre of Biological Systems”, Martin G. Hicks and Carsten Kettner (Eds.), Proceedings of the Beilstein-Institut Workshop, May24th-28th 2004, Bozen, Italy. ISBN 3-8325-1019-2. Pages 1-31.
582. Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer Supported Reagents and Scavengers I.R. Baxendale and S.V. Ley, Ind. Eng. Chem. Res., 2005, 44, 8588-8592.
581. Total Synthesis of Two Novel Subpicomolar Sarco/Endoplasmic Reticulum Ca2+ ATPase (SERCA) Inhibitors Designed by an Analysis of the Binding Site of Thapsigargin H. Søhoel, T. Liljefors, S.V. Ley, S.F. Oliver, A. Antonello, M.D. Smith, C.E.Olsen, J.T. Isaacs, S.B. Christensen, J. Med. Chem., 2005, 48, 7005-7011.
580. Michael, Michael-Aldol and Michael-Michael Reactions of Enolate Equivalents of Butane-2,3-diacetal Protected Glycolic Acid Derivatives S.V. Ley, D.J. Dixon, R.T. Guy, F. Rodriguez, and T.D. Sheppard, Org. Biomol. Chem. 2005, 3, 4095-4107.
579. A Versatile Organocatalyst for the Asymmetric Conjugate Addition of Nitroalkanes to Enones C.E.T. Mitchell, S.E. Brenner and S.V. Ley, J. Chem. Soc. Chem Commun., 2005, 5346-5548.
578. A Highly Selective, Organocatalytic Route to Chiral Dihydro-1,2-oxazines S. Kumarn, D.M. Shaw, D.A. Longbottom and S.V. Ley, Org. Lett., 2005, 7, 4189-4191.
577. Synthesis of Alkaloid Natural Products using Solid-Supported Reagents and Scavengers I.R. Baxendale and S.V. Ley, Curr. Org. Chem., 2005, 9, 1521-1534.
576. Non-Metal Catalysed Intramolecular Alkyne Cyclotrimerization Reactions Promoted by Focussed Microwave Heating in Batch and Flow Modes S. Saaby, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem. 2005, 3, 3365-3368.
575. Total Synthesis of Spongistatin I: A New Synthetic Strategy Exploiting its Latent Pseudo Symmetry M. Ball, M.J. Gaunt, D.F. Hook, A.S. Jessiman, S. Kawahara, P. Orsini, A. Scolaro, A.C. Talbot, H.R. Tanner, S. Yamanoi and S.V. Ley, Angew. Chem. Int. Ed., 2005, 44, 5433-5438.
574. A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Organic Synthesis J. Siu, I.R. Baxendale, R.A. Lewthwaite and S.V. Ley, Org. Biomol. Chem., 2005, 3, 3140-3160.
573. Synthesis of the EF-Fragment of Spongistatin I S. Kawahara, M.J. Gaunt, A. Scolaro, S. Yamanoi, P. Orsini and S.V. Ley, Synlett., 2005, 2031-2034.
572.Integrating Microwave-Assisted Synthesis and Solid-Supported Reagents I.R. Baxendale, A-L. Lee and S.V. Ley. Microwave-Assisted Organic Synthesis, eds. J.P. Tierney and P. Lidstrom, 2005, Blackwells ISBN 1-4051-1560-2.
571. The use of a Continuous Flow-Reactor Employing a Mixed Hydrogen-Liquid Flow Stream for the Efficient Reduction of Imines to Amines S. Saaby, K.R. Knudsen, M. Ladlow and S.V. Ley, J. Chem. Soc., Chem. Commun., 2005, 2909-2911.
570. The First Lewis Acid Catalysed Allylboronate Additions to Aldehydes Commentary by D.E.A. Brittain and S.V. Ley, Chemtracts, 2005, 17, 620-626.
569. Development of Methods Suitable for Natural Product Synthesis: The Azadiractin Story S.V. Ley, Pure and Appl. Chem., 2005, 77, 1115-1130.
568. Formation of 4-Aminopyrimidines via Trimerization of Nitriles using Focused Microwave Heating I.R. Baxendale and S.V. Ley, J. Combinatorial Chem. 2005, 7, 483-489.
567. A Highly Automated, Polymer-Assisted Strategy for the Preparation of 2-Alkylthiobenzimidazoles and N,N’-Dialkylbenzimidazolin-2-ones E. Vickestaffe, B.H. Warrington, M. Ladlow and S.V. Ley, J. Combinatorial Chem., 2005, 7, 385-397.
566. The Rapid Preparation of 2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Microwave Heating I.R. Baxendale, M. Martinelli and S.V. Ley, Tetrahedron 2005, 61, 5323-5349.
565. Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions S. Lohmann, S.P. Andrews, M.J. Burke, M.D. Smith, J.P. Attfield, H. Tanaka, K. Kaneko and S.V. Ley, Synlett., 2005, 1291-1295.
564. Electronic Encyclopaedia of Reagents in Organic Synthesis. Ed. L.A. Paquette. “(S)-5-Pyrrolidin-2-yltetrazole and (R)-5-Pyrrolidin-2-yltetrazole“; A.J.A. Cobb, S.V. Ley, D.A. Longbottom and D.M Shaw, DOI: 10.1002/047084289X.rn00615.
563. Total Synthesis of Antascomicin B D.E.A. Brittain, C.M. Griffiths-Jones, M.R. Linder, M.D. Smith, C McCusker, J.S. Barlow, R. Akiyama, K. Yasuda and S.V. Ley, Angew. Chem., Int. Ed., 2005, 44, 2732-2737.
562. Efficient Batch and Continuous Flow Suzuki Cross-Coupling Reactions under Mild Conditions, Catalysed by Polyurea-encapsulated Palladium(II)acetate and Tetra-n-butylammonium Salts C.K.Y. Lee, A.B. Holmes, S.V. Ley, I.F. McConvey, B. Al-Duri, G.A. Leeke, R.C.D. Santos and J.P.K. Seville, J. Chem. Soc., Chem. Commum., 2005, 2175-2177.
561. Heterogeneous or Homogeneous? A Case Study Involving Palladium-Containing Perovskites in the Suzuki Reaction S.P. Andrews, A.F. Stepan, H. Tanaka, K. Kaneko, S.V. Ley and M.D. Smith, Adv. Syn. and Cat., 2005, 347, 647-654.
560. Steroselective Synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2-(4-fluorophenoxymethyl)-3.4-O-isopropylidene tetrahydrofuran from Mannose Diacetonide G.V.M. Sharma, S. Punna, L. Hymavathi, N.Y. Reddy, P.R. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 1135-1140.
559. Stereoselective Synthesis of Chiral Tetrahydrofurans with Potent 5-LO Inhibitory Activity G.V.M. Sharma, S. Punna, P.R. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 1125-1133.
558. Stereoselective Synthesis of Pharmaceutically Relevant Chiral Tetrahydrofurans for (R)- and (S)-Gyceraldehyde Derivatives G.V.M. Sharma, S. Punna, T.R. Prashad, P.R. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 1113-1123.
557. Stereoselective Synthesis of (2S, 7S)-7-(4-phenoxymethyl)-2-(1-N-Hydroxyureidyl-3-butyn-4-yl)oxepane: A Potential Anti-Asthmatic Drug Candidate M.K. Gurjar, B.V. Rao, L.M. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 935-939.
556. Highly Diastereoselective Desymmetrisation of Cyclic meso-Anhydrides and Derivatisation to Mono-Protected 1,4-Diols A.C. Evans, D.A. Longbottom, M. Matsuoka and S.V. Ley, Synlett., 2005, 646-648.
555. A Homo-Proline Tetrazole as an improved Organocatalyst for the Asymmetric Michael Addition of Carbonyl Compound to Nitro-Olefins C.E.T. Mitchell, A.J.A. Cobb and S.V. Ley, Synlett, 2005, 611-614.
554. Synthesis of a Ceramide Sphingolipid as a Potential Sex Pheromone of the Hair Crab Erimacrus isembeckii using Butane-2,3-diacetal Desymmetrised Glycolic Acid Building Blocks D.J. Dixon, S.V. Ley, S. Lohmann and T.D. Sheppard, Synlett., 2005, 481-484.
553. Organic Chemistry in Ionic Liquids using Non-Thermal Energy Transfer Processes J. Habermann, S. Ponzi and S.V. Ley, Mini Reviews in Org. Chem., 2005, 2, 125-137.
552. The Total Synthesis of the Annonaceous Acetogenin, 10-Hydroxyasimicin G.L. Nattrass, E. Diez, M. McLachlan, D.J. Dixon and S.V. Ley, Angew. Chem. Int. Ed., 2005, 44, 580-584.
551. Total Synthesis of the Fusarium Toxin Equisetin L.T. Burke, D.J. Dixon, S.V. Ley and F. Rodríguez, Org. Biomol. Chem., 2005, 3, 274-280.
550. Organocatalysis with Proline Derivatives: Improved Cataysts for the Asymmetric Mannich, Nitro- Michael and Aldol Reactions A.J. Cobb, D.M. Shaw, D.A. Longbottom, J.B. Gold and S.V. Ley, Org. Biomol. Chem., 2005, 3, 84-96.
549. The 1702 Chair of Chemistry at Cambridge: Transformation and Change Eds. M. Archer and C. Haley, Chemistry in a Changing World: New Tools for the Modern Molecule Maker, S.V. Ley, Cambridge University Press, 2005, Ch. 12, 283-303. ISBN 0 521 82873 2.
548. In Honour of Professor Leo A. Paquette S.V. Ley, Heterocycles, 2004, 62, 1-3.
547. Studies on the Generation of Enolate Anions from Butane-2,3-diacetal Protected Glycolic Acid Derivatives and Subsequent Highly Diastereoselective Coupling Reactions with Aldehydes and Acid Chlorides S.V. Ley, D.J. Dixon, R.T. Guy, M.A. Palomero A. Polara, F. Rodriguez and T.D. Sheppard, Org. Biomol. Chem., 2004, 2, 3618-3627.
546. Preparation of Enantiopure Butane-2,3-diacetals of Glycolic Acid and Alkylation Reactions leading to α-Hydroxyacid and Amide Derivatives S.V. Ley, E. Diez, D.J. Dixon, R.T. Guy, P. Michel and T.D. Sheppard, Org. Biomol. Chem., 2004, 2, 3608-3617.
545. Evolving Cascades: The Claisen Rearrangement in the Development of Tandem Sequences of Three or More Reactions Commentary by B.L. Gray and S.V. Ley, Chemtracts, 2004, 235-241.
544. Enantioselective Organocatalytic Cyclopropanation with Ammonium Ylides C.D. Papageorgiou, M.A. Cubillo de Dios, S.V. Ley and M.J. Gaunt, Angew. Chem. Int. Ed., 2004, 43, 4641-4644.
543. A Concise Total Synthesis of (+) Okaramine C, E. Cleator, P.R. Hewitt and S.V. Ley, Org. Biomol. Chem., 2004, 2, 2415-2417.
542. Synthesis of the Thapsigargins S.V. Ley, A. Antonello, E.P. Balskus, D.T. Booth, S.B. Christensen, E. Cleator, H. Gold, K. Högenauer, U. Hünger, R.M. Myers, S.F. Oliver, O. Simic, M.D. Smith, H. Søhoel, and A.J.A. Woolford Proc. Nat. Acad. Sci., 2004, 101, 12073-12078.
541. 5-Pyrrolidin-2-yltetrazole as an Asymmetric Organocatalyst for the Addition of Ketone to Nitro-Olefins A.J. Cobb, D.A. Longbottom, D.M. Shaw and S.V. Ley, J. Chem. Soc. Chem. Commum., 2004, 1808-1809.
540. The Preparation and Alkylation of a Butanedione-Derived Chiral Glycine Equivalent and its use for the Synthesis of alpha-Amino Acids and alpha, alpha-Disubstituted Amino Acids C.I. Harding, D.J. Dixon and S.V. Ley, Tetrahedron, 2004, 60, 7679-7692.
539. Development of an Indole Safety-Catch Linker for use in Analytical Constructs J.J. Scicinski, M.S. Congreve and S.V. Ley, J. Combinatorial Chem., 2004, 6, 375-384.
538. Fully Automated Polymer-Assisted Synthesis of 1,5-Biaryl Pyrazoles E. Vickerstaff, B.H. Warrington, M. Ladlow and S.V. Ley, J. Combinatorial Chem., 2004, 6, 332-339.
537.An Intramolecular Organocatalytic Cyclopropanation Reaction N. Breymer, S.C. Smith, S.V. Ley and M.J. Gaunt, Angew. Chem. Int. Ed., 2004, 43, 2681-2684.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C R.I. Storer, T. Takemoto, P.S. Jackson, D.S. Brown, I.R. Baxendale and S.V. Ley, Chem. Eur. J., 2004, 10, 2529-2547.
535. Anomeric Oxygen to Carbon Rearrangement of Alkynyl Tributylstannane Derivatives of Furanyl (γ)- and Pyranyl (δ)-Lactols M.F. Buffet, D.J. Dixon, S.V. Ley, D.J. Reynolds and R.I. Storer, Org. Biomol. Chem., 2004, 2, 1145-1154.
534. Grignard Additions to 2-Uloses: Synthesis of Stereochemically Pure Tertiary Alcohols E. Cleator, C.F. McCusker, F. Stelzer and S.V. Ley, Tetrahedron Lett., 2004, 45, 3077-3080.
533. Catalytic polymer-supported potassium thiophenolate in methanol for the removal of ester, amide and thioacetate protecting groups R.N. MacCoss, D.J. Henry, C. T. Brain, S.V. Ley, Synlett 2004, 675-678.
532. Polymer-Assisted Multistep Solution Phase Synthesis and Biological Screening of Histone Deacetylase Inhibitors A. Bapna, M. Ladlow, E. Vickerstaff, B.H. Warrington, T-P. Fan and S.V. Ley, Org. Biomol. Chem., 2004, 2, 611-620.
531. 5-Pyrrolidin-2-yltetrazole: A New, Catalytic, More Soluble Alternative to Proline in an Organocatalytic Asymmetric Mannich-type Reaction A.J.A. Cobb, D.M. Shaw and S.V. Ley, Synlett., 2004, 558-560.
530. Microwave Assisted Leimgruber-Batcho Reaction for the preparation of Indoles, Azaindoles and Pyrroylquinolines J. Siu, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem., 2004, 2, 160-167.
529. The Synthesis of (-)-Gloeosporone, a Potent Fungal Autoinhibitor of Spore Germination using a pi-Allytricabonyl iron Lactone Complex and a New Reductive Decomplexation Procedure for the Installation of the Embedded 1,7-Diol Component of the Natural Product E. Cleator, J. Harter and S.V. Ley, Heterocycles, 2004, 62, 619-633.
528. Preparation of Butane-1,2-diacetal Protected L-Glyceraldehyde from D-Mannitol S.V. Ley and P. Michel, Synthesis, 2004, 147-150.
527. Copper(I)-Catalysed Preparation of (E)-3-Iodoprop-2-enoic Acid D.J. Dixon, S.V. Ley and D.A. Longbottom, Org. Syn., 2003, 80, 129-132.
526. Therapeutic Inhibition of C-Reactive Protein – Novel Drugs, Novel Mechanisms G.M. Hirschfield, M.D. Smith, S.V. Ley, S. Kolstoe, D. Thompson, S.P. Wood and M.B. Pepys, Clinical Sci., 2003, 104 (Suppl. 49) 65-66.
525. Enantioselective Synthesis of the Tetrahydrobenzylisoquinoline Alkaloid (-)-Norarmepavine using Polymer-Supported Reagents I.R. Baxendale, T.D. Davidson S.V. Ley and R.H. Perni, Heterocycles, 2003, 60, 2707-2715.
524. A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide and Thapsivillosin F S.F. Oliver, K. Hoegenauer, O. Simic, A. Antonello, M.D. Smith and S.V. Ley, Angew. Chem., Int. Ed., 2003, 42, 5996-6000.
523. Synthesis of the C-1-C-28 ABCD Unit of Spongistatin 1 M. J. Gaunt, A. Jessiman, P. Orsini and S.V. Ley, Org. Lett., 2003, 5 , 4819-4822.
522. A Practical and Efficient Synthesis of the C-16 to C-28 Spiroketal Fragment (CD) of the Spongistatins M.J. Gaunt, D.F. Hook and S.V. Ley, Org. Lett., 2003, 5, 4815-4818.
521. Development of New Synthetic Tools for the Preparation of Biologically Active Molecules S.V. Ley, I.R. Baxendale and P.Grice, NATO/FEBS International Summer School, Spetses, Greece, “Chemical Probes in Biology”, M. Schneider ed., Kluwer Academic Publishers, Netherlands, p 235-244.
520. The Use of Butane Diacetals of Glycolic Acid as Precursors for the Synthesis of the Phytotoxic Camodulin Inhibitor Herbarumin II E. Diez, D.J. Dixon, S.V. Ley, A. Polara and F. Rodríguez, Helv.Chim. Acta., 2003, 86, 3717-3729.
519. Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for the Hydrogenolysis of Epoxides C. Mitchell, D. Pears, S.V. Ley, J-Q. Yu and W. Zhou, Org. Lett., 2003, 5, 4665.
518. A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives S.V. Ley, P. Michel and C. Trapella, Org. Lett., 2003, 5, 4553.
517. Modern Synthetic Methods for Copper-Mediated C(Aryl)-O,C (Aryl)-N and C(Aryl)-S Bond Formation S.V. Ley and A. W. Thomas, Angew. Chem. Int. Edn., 2003, 42, 5400.
516. The Synthesis of the Anti-Malarial Natural Product Polysphorin and Analogues using Polymer-Supported Reagents and Scavengers A-L. Lee and S.V. Ley, Org. Biomol. Chem., 2003, 1, 3957.
515. Palladium-containing Perovskites: Recoverable and Reusable Catalysts for Suzuki Couplings M.D. Smith, C Ramarao, P.E. Brennan, A.F. Stepan and S.V. Ley, J. Chem. Soc., Chem. Commun., 2003, 2652.
514. A Rapid Stereocontrolled Synthesis of the 3a-Hydroxy-pyrrolo[2,3b]indole Skeleton, a Building Block for 10b-Hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-dione S.V. Ley, E. Cleator and P.R. Hewitt, Org. Biomol. Chem., 2003 , 1, 3492.
513. A Sequential Tetra-n-propylammonium Perruthenate-Wittig Oxidation R.N. MacCoss, E.P. Balskus, S.V. Ley, Tetrahedron Lett., 2003, 44, 7779.
512. Synthesis of (-)-Gloeosporone, a Fungal Autoinhibitor of Spore Germination using a π-Allyltricarbonyliron Lactone Complex as a Templating Architecture for 1,7-Diol Construction E. Cleator, J. Harter, C.J. Hollowood and S.V. Ley, Org. Biomol. Chem., 2003, 1, 3263.
511.1,5-Asymmetric Induction of Chirality using π-Allyltricarbonyliron Lactone Complexes: Highly Diastereoselective Synthesis of α-Functionalised Carbonyl Compounds C.J. Hollowood, S.V. Ley, and E.A. Wright, Org. Biomol. Chem., 2003, 1, 3208.
510. Reductive Decomplexation of π-Allyltricarbonyliron Lactone Complexes using Sodium Naphthalenide as a Route to Stereodefined 1,7-diols and 2,3-diene-1,7-diols C.J. Hollowood and S.V. Ley, Org. Biomol. Chem., 2003, 1, 3197.
509. Total Synthesis of the Polyenoyltetramic Acid Polycephalin C D.A. Longbottom, A.J. Morrison, D.J. Dixon and S.V. Ley, Tetrahedron, 2003, 59, 6955.
508. Rhodium-Catalysed Coupling of Heterocycles and Alkenes: A Novel Mechanism of C-H Activation, Commentary by E.P. Balskus and S.V. Ley, Chemtracts, 2003, 443.
507. Synthesis of Enantiomers of Butane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-Protected Glycolic Acid P. Michel and S.V. Ley, Synthesis, 2003, 1598.
506. Supported Reagents and Scavengers in Multi-Step Organic Synthesis I.R. Baxendale, R.I. Storer and S.V. Ley in “Polymeric Materials in Organic Synthesis and Catalysis”. Ed. M.R. Buchmeiser VCH Berlin, ISBN. 3-527-30630-7, 2003, 53.
505. Fully Automated Multi-step Solution Phase Synthesis using Polymer Supported Reagents: Preparation of Histone Deacylase Inhibitors E. Vickerstaff, M. Ladlow, S.V. Ley and B. Warrington, Org. Biomol. Chem., 2003, 1, 2419.
504. Total Synthesis of the Phytotoxic Agent Herbarumin II using Butane Diacetals of Glycolic Acid as Building Blocks E. Diez, D.J. Dixon, S.V. Ley, A. Polara and F. Rodriguez, Synlett., 2003, 1186.
503. A Total Synthesis of Epothilones using Solid-Supported Reagents and Scavengers R.I. Storer, T. Takemoto, P.S. Jackson and S.V. Ley, Angew. Chem. Int. Edn., 2003, 42, 2321.
502. Synthesis of Carbohydrate Derivatives Using Solid-Phase Work-Up and Scavenging Techniques R.N. MacCoss, P.E. Brennan and S.V. Ley, Org. Biomol. Chem., 2003, 1, 2029.
501. Versatile Solid-Phase Synthesis of Secondary Amines from Alcohols. Development of an N-Boc-(o-nitrobenzene) Sulfonamide Linker M.S. Congreave, C. Kay, J.J. Scicinski, S.V. Ley, G. Williams, P.J. Murray, S.C. McKeown and S.P. Watson, Tetrahedron Lett., 2003, 44, 4153.
500. Use of π-Allyltricarbonyliron Lactone Complexes in the Synthesis of Taurospongin A: A Potent Inhibitor of DNA Polymerase β and HIV Reverse Transcriptase C.J. Hollowood, S.V. Ley and S. Yamanoi, Org. Biomol. Chem., 2003, 1, 1664.
499. Addition of Dithiols to Bis-ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products H.F. Sneddon, M.J. Gaunt and S.V. Ley, Org. Lett., 2003, 5, 1147.
498. Transfer Hydrogenation using Recyclable Polyurea-Encapsulated Palladium: Efficient and Chemoselective Reduction of Aryl Ketones J-Q Yu, H-C. Wu, C. Ramarao, J.B. Spencer and S.V. Ley, J. Chem. Soc., Chem. Commun., 2003, 678.
497. Organic-Catalyst-Mediated Cyclopropanation Reaction C.D. Papageorgiou, S.V. Ley and M.J. Gaunt, Angew. Chem. Int. Edn., 2003, 42, 828.
496. A 2,3-Butanedione Protected Glycine Equivalent: A New Building block for the Stereoselective Synthesis of Enantiopure N-Protected a-Amino Acids D.J. Dixon, C.I. Harding, S.V. Ley and D.M.G. Tilbrook. J. Chem. Soc., Chem. Commun., 2003, 468.
495. Microencapsulation of Osmium Tetroxide in Polyurea S.V. Ley, C. Ramarao, A-L. Lee, N. Østergaard, S.C. Smith and I.M. Shirley, Org. Lett., 2003, 5, 185.
494. Development of β-Keto 1,3-Dithianes as Versatile Intermediates for Organic Synthesis M.J. Gaunt, H.F. Sneddon, P.R. Hewitt, P. Orsini, D.F. Hook and S.V. Ley, Org. Biomol. Chem., 2003, 1, 15.
493. Applications of DiMaS: A New Mass Spectrometry Tagging Strategy to Focussed Peptide Libraries C. Kay, A. Amour, M.I. Bird, O. Heudi, S.V. Ley, P. Marshall, S.C. McKeown and C.L. Smith, “Innovation Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries”, Collect. Pap., Int. Symp., 9th ISBN 0-9515735-4-3, 2002, 85.
492. Benzotriazoles in Solid Phase Organic Chemistry Commentary by M. Donghi, J. Habermann and S.V. Ley, Chemtracts, 2002, 751.
491. Sir Derek Harold Richard Barton S.V. Ley and R.M. Myers, Biogr. Mems. Fell. R. Soc. Lond., 2002, 48, 1.
490. Azadirachtin Disrupts Formation of Organised Microtubule Arrays During Microgametogenesis of Plasmodium berghei O. Billker, M.K. Shaw, I.W. Jones, S.V. Ley, A.J. Mordue and R.E. Sinden, J. Eukaryot. Microbiol., 2002, 49, 489.
489. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Perruthenate”, S.V. Ley and C. Ramarao, DOI: 10.1002/047084289X.rn00029.
488. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Carbonate”, S.V. Ley and R. N. Bream, DOI: 10.1002/047084289X.rn00028.
487. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Hydroxide”, S.V. Ley, I.R. Baxendale and A-L. Lee, DOI: 10.1002/047084289X.rn00058.
486. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Ammonium Periodate”, S.V. Ley and A.J. Hazelwood, DOI: 10.1002/047084289X.rn00030.
485. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Scwhiesinger Base” S.V. Ley and J.J. Scicinski, DOI: 10.1002/047084289X.rn00026.
484. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Borohydride Exchange Resin”, S.V. Ley and R.I. Storer, DOI: 10.1002/047084289X.rn00027.
483. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Acid”, S.V. Ley and A. Horvath, DOI: 10/1002/047084289X.rn00059.pub2.
482. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Thiophenol”, S.V. Ley, D.J. Henry and M. Matsuoka, DOI: 10.1002/047084289X.rn00031.
481. Application of ReactArray Robotics and Design of Experiment Techniques in Optimisation of Supported Reagent Chemistry C. Jamieson, M.S. Congreave, D.F. Emiabata-Smith, S.V. Ley and J.J. Scicinski, Org. Proc. Res. Dev., 2002, 6, 823.
480. Organic Synthesis in a Changing World S.V. Ley and I.R. Baxendale, Chem. Record, 2002, 2, 377.
479. Total Synthesis of the Cyclic Peptide Argyrine B S.V. Ley and A. Priour, Eur. J. Org. Chem., 2002, 3995.
478. A Mild, Enantioselective Synthesis of (R)-Salmeterol via Sodium Borohydride, Calcium Chloride Asymmetric Reduction of a Phenacyl Phenylglycinol Derivative R.N. Bream, S.V. Ley, B. McDermott and P.A. Procopiou, J. Chem. Soc., Perkin Trans. 1, 2002, 2237.
477. Highly Selective Entry to the Azadirachtin Skeleton via a Claisen Rearrangement/Radical Cyclization Sequence T. Duran-Reville, L.A. Gobbi, B.L. Gray, S.V. Ley, and J.S. Scott, Org. Lett., 2002, 4, 3847.
476. Synthesis of the β2 Agonist (R)-Salmeterol using a Sequence of Supported Reagents and Scavenging Agents R.N. Bream, S.V. Ley and P.A. Procopiou, Org. Lett., 2002, 4, 3793.
475. Palladium Acetate in Polyurea Microcapsules: A Recoverable and Reversible Catalyst for Hydrogenations N. Bremeyer, S.V. Ley, C. Ramarao, I.M. Shirley and S.C. Smith, Synlett, 2002, 1843.
474. Butane-2,3-Diacetals of Glyceraldehyde: A New, Stable Alternative to Glyceraldehyde Acetonide P. Michel and S.V. Ley, Angew. Chem. Int. Edn., 2002, 41, 3898.
473. Highly Diastereoselective Ketone Aldol Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid D.J. Dixon, A. Guarna, S.V. Ley, A. Polara and F. Rodríguez, Synthesis, 2002, 1973.
472. Application of Polymer-Supported Enzymes and Reagents in the Synthesis of γ–Aminobutyric Acid GABA AnaloguesI.R. Baxendale, M. Ernst, W-R. Krahnert and S.V. Ley, Synlett, 2002, 1641.
471. Analytical Techniques for Small Molecule Solid Phase Synthesis J.J. Scicinski, M.S. Congreve, C. Kay and S.V. Ley, Curr. Med. Chem., 2002, 9, 2103.
470. Synthesis, Structure Revision and Absolute Configuration of Didemniserinolipid B, a Serinol Marine Natural Product from a Tunicate Didemnum sp., H. Kiyota, D.J. Dixon, C.K. Luscombe, S. Hettstedt and S.V. Ley, Org. Lett., 2002, 4, 3223.
469. Reductive Decomplexation of p-Allyltricarbonyliron Lactone Complexes: A New Route to Stereo-defined 1,7-Diols and 2,3-Diene-1,7-diols S.V. Ley and C.J. Hollowood, J. Chem. Soc., Chem. Commun., 2002, 2130.
468. Total Synthesis of the Amaryllidacea Alkaloid (+)-Plicamine using Solid-Supported Reagents I.R. Baxendale, S.V. Ley, C. Piutti and M. Nesi, Tetrahedron, 2002, 58, 6285.
467. Total Synthesis of Polycephalin C and Determination of the Absolute Configurations at the 3”, 4” Ring Junction D.A. Longbottom, A.J. Morrison, D.J. Dixon and S.V. Ley, Angew. Chem., Int. Edn., 2002, 41, 2786.
466. A Concise Synthesis of Carpanone using Solid-Supported Reagents and Scavengers I.R. Baxendale, A-L. Lee and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 1850.
465. A Polymer Supported [1,3,2] Oxazapholidine for the Conversion of Isothiocyanates to Isocyanides and their Subsequent Use in an Ugi Reaction S.V. Ley and S.J. Taylor, Bioorg. Med. Chem. Lett., 2002, 12, 1813.
464. Synthesis of Taurospongin A: A Potent Inhibitor of DNA Polymerase and HIV Reverse Transcriptase using p-Allyltricarbonyliron Lactone Complexes C.J. Hollowood, S.V. Ley and S.Yamanoi, J. Chem. Soc., Chem. Commun., 2002, 1624.
463. New Tools and Concepts in Modern Organic Synthesis S.V. Ley and I.R. Baxendale, Nature Reviews, 2002, 1, 573.
462. Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and its Unnatural Enantiomer by using Solid-Supported Reagents and Scaveners in a Multistep sequence of Reactions I.R. Baxendale, S.V. Ley and C. Piutti, Angew. Chem. Int. Edn., 2002, 41, 2194.
461. Polyurea-Encapsulated Palladium (II) Acetate: A Robust and Recyclable Catalyst for use in Conventional and Supercritical Media S.V. Ley, C. Ramarao, R.S. Gordon, A.B. Holmes, A.J. Morrison, I.F. McConvey, I.M. Shirley, S.C. Smith and M.D. Smith, J. Chem. Soc., Chem. Commun., 2002, 1134.
460. Encapsulation of Palladium in Polyurea Microcapsules C. Ramarao, S.V. Ley, S.C. Smith, I.M. Shiley and N. DeAlmeida, J. Chem. Soc., Chem. Commun., 2002, 1132.
459. A Clean Conversion of Aldehydes to Nitriles using a Solid-Supported Hydrazine I.R. Baxendale, S.V. Ley and H.P. Sneddon, Synlett, 2002, 775.
458. Solid-Supported Reagents for Multi-Step Organic Synthesis: Preparation and Application S.V. Ley, I.R. Baxendale, G. Brusotti, M. Caldarelli, A. Massi and M. Nesi, Il Farmaco, 2002, 57, 321.
457. The Total Synthesis of the Annonaceous Acetogenin Muricatetrocin C, D.J. Dixon, S.V. Ley, D.J. Reynolds, Chem. Eur. J., 2002, 8, 1621.
456. Analytical Construct Resins for Analysis of Solid Phase Chemistry M.S. Congreve, S.V. Ley and J.J., Scicinski, Chem. Eur. J., 2002, 8, 1768.
455. The Simultaneous Use of Immobilised Reagents for the One-Pot Conversion of Alcohols to Carboxylic Acids K. Yasuda and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 1024.
454. The Use of π-Allyltricarbonyliron Lactone Complexes in the Synthesis of the Resorcyclic Macrolides and Zearalenol S. Burckhardt and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 874.
453. Total Synthesis of the Cyclic Heptapeptide Argyrin B: A New Potent Inhibitor of T-Cell Independent Antibody Formation S.V. Ley, A. Priour and C. Heusser, Org. Lett., 2002, 4, 711.
452. Synthesis of Trifluoromethyl Ketones using Polymer Supported Reagents I.R. Baxendale, S.V. Ley, W. Lumeras and M. Nesi, Combinatorial Chem. and High Throughput Screening, 2002, 5, 145.
451. A Polymer-Supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds I.R. Baxendale, A-L Lee and S.V. Ley, Synlett, 2002, 516.
450. The Effects of Phytochemical Pesticides on the Growth of Cultured Invertebrate and Vertebrate Cells A. Salehzadeh, A. Jabbar, L. Jennens, S.V. Ley, R.S. Annadurai, R. Adams and R.H.C. Strong, Pest. Manag. Sci., 2002, 58, 268.
449. Synthesis of Nornicotine, Nicotine and Other Functionalised Derivatives Using Solid-Supported Reagents and Scavengers I.R. Baxendale, G. Brusotti, M. Matsuoka and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 143.
448. Tritiated Dihydroazadiractin Binding to Schistocerca Gregaria Testes and Spodoptera Sf9 Cells Suggests a Similar Cellular Mechanism of Action for Azadirachtin A.J. Mordue, A.J. Nisbet, Lyn Jennens, S.V. Ley, and W. Mordue, 1999 Azadirachta indica A. Juss. Int. Neem Conference, Gatton, Australia. Eds R.P. Singh and R.C. Saxena, Oxford and IBH Publ. Co PVT. Ltd, Chapter 22, 247-256.
447. Consecutive Three- and Four-Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative D.J. Dixon, S.V. Ley and F. Rodríguez, Angew. Chem. Int. Edn., 2001, 40, 4763.
446. The Total Synthesis of (+)-Aspicilin using 2,3-Butane Diacetal Protected Butane Tetrols via a Chiral Memory Protocol D.J. Dixon, A.C. Foster and S.V. Ley, Can. J. Chem., 2001, 79, 1668.
445. A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977 D.J. Dixon, S.V. Ley, D.J. Reynolds and M.S. Chorghade, Ind. J. Chem., 2001, 39, 1043.
444. Highly Diastereoselective Michael Addition Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid. Preparation of α-Hydroxy-γ-amino Acid Derviatives D.J. Dixon, S.V. Ley and F. Rodríguez, Org. Lett., 2001, 3, 3753.
443. Highly Diastereoselective Lithium Enolate Aldol Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid and Deprotection to Enantiopure anti-2,3-Dihydroxy Esters D.J. Dixon, S.V. Ley, A. Polara and T. Sheppard, Org. Lett., 2001, 3, 3749.
442. A New Route to Butane -1,2-Diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products S.V. Ley and P. Michel, Synlett, 2001, 1793.
441. (–)-(4S)-1-Chloro-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-propan-2-one Structure Reports Online J.E. Davies, D.F. Hook and S.V. Ley, Acta Cryst. Section E, 2001, 1098.
440. Tetra-N-Propylammonium Perruthenate: A Case Study in Catalyst Recovery and Reuse Involving Tetraalkylammonium Salts S.V. Ley, C. Ramarao and M.D. Smith, J. Chem. Soc., Chem. Commun., 2001, 2278.
439. Rapid Assembly of Anti-Anto-1,2,3-Triol Motifs via Stereoselective Addition of Organometallics to Aldehydes Obtained from (R’,R’,S,R)-2,3-Butane Diacetal Protected Butane Tetraol Derivatives D.J. Dixon, L. Krause and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2001, 2516.
438. Solid-Supported Reagents for the Oxidation of Aldehydes to Carboxylic Acids T. Takemoto, K. Yasuda and S.V. Ley, Synlett, 2001, 1555.
437. The Bestmann Ylide as a Multi-Purpose Wittig Reagent Commentary by J. Habermann and S.V. Ley, Chemtracts, 2001, 386.
436. A Concise Synthesis of the Natural Product Carpanone using Solid-Supported Reagents and Scavengers I.R. Baxendale, A.-L. Lee and S.V. Ley, Synlett, 2001, 1482.
435. Both Mosquito-Derived Xanthurenic Acid and a Host Blood-Derived Factor Regulate Gamentogenesis of Plasmodium in the Mid-Gut of the Mosquito M. Arai, O. Billker, H.R. Morris, M. Panico, M. Delcroix, D.J. Dixon, S.V. Ley and R. E. Sinden, Mol. Biochem. Parasitol., 2001, 116, 17.
434. Butane-2,3-diacetal Desymmetrised Glycolic Acid – A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids E. Diez, D.J. Dixon and S.V. Ley, Angew. Chem. Int. Ed. Engl., 2001, 40, 2906.
433. New Polyethylene Glycol Polymers as Ketal Protecting Groups: A Polymer Supported Approach to Symmetrically Substituted Spiroketals R. Haag, A.G. Leach, S.V. Ley, M. Nettekoven, J. Schnaubelt, Syn. Commun., 2001, 31, 2965-2977.
432. Development and Application of a Carbonyl-13C Enriched BAL Linker for Solid Phase Reaction Monitoring C. Jamieson, M.S. Congreve, P.R. Hewitt, J.J. Scicinski and S.V. Ley, J. Combinatorial Chem., 2001, 3, 397.
431. Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis using Analytical Constructs J.J. Scicinski, M.C. Congreave, C. Jamieson, S.V. Ley, E.S. Newman, V.M. Vinader and R.A.E. Carr, J. Combinatorial Chem, 2001, 3, 387.
430. The Development and Application of Supported Reagents for Multi-step Organic Synthesis S.V. Ley and I.R. Baxendale in ‘Supported Catalysts and their Applications’, Ed. D.C. Sherrington and A.P. Kybett, The Royal Society of Chemistry Proceedings, 2001, 9.
429. New Catalyst for Olefin Metathesis Commentary by P.E. Brennan and S.V. Ley, Chemtracts, 2001, 88.
428. A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging S.V. Ley, A. Massi, F. Rodríguez, D.C. Horwell, R.A. Lewthwaite, M.C. Pritchard and A.M. Reid, Angew. Chem. Int. Ed., 2001, 40, 1053.
427. A Polymer-Supported Thiolating Agent S.V. Ley, A.G. Leach and R.I. Storer, J. Chem. Soc., Perkin Trans. 1, 2001, 358.
426. 1,2- Diacetals: A New Opportunity for Organic Synthesis S.V. Ley, D.K. Baeschlin, D.J. Dixon, A.C. Foster, S.J. Ince, H.W.M. Priepke and D.J. Reynolds, Chem. Rev., 2001, 101, 53.
425. Solid Phase Reaction Monitoring-Chemical Derivatisation and Off-Bead Analysis C. Kay, O.E. Lorthior, N.J. Parr, M. Congreve, S.C. McKeown, J.J. Scicinski and S.V. Ley, Analytical Methods for Combinatorial Chemistry, Biotechnol. Bioeng., 2000, 71, 110.
424. Multistep Organic Synthesis using Solid Supported Reagents and Scavengers: A New Paradigm in Chemical Library Generation S.V. Ley, I.R. Baxendale, R.N. Bream, P.S. Jackson, A.G. Leach, D.A. Longbottom, M. Nesi, J.S. Scott, R.I. Storer and S.J. Taylor, J. Chem. Soc., Perkin Trans. 1, 2000, 3815.
423. Deracemization of Baylis-Hillman Adducts Commentary by S.V. Ley and F. Rodríguez, Chemtracts, 2000, 596.
422. New Strategies for Organic Synthesis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction Commentary by E. Diez and S.V. Ley, Chemtracts, 2000, 592.
421. A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin L. T. Burke, D.J. Dixon, S.V. Ley and F. Rodríguez, Org. Lett., 2000, 2, 3611.
420. A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis C. Jamieson, M.S. Congreave, D.F. Emiabata-Smith and S.V. Ley, Synlett, 2000, 1603.
419. The Total Synthesis of the Annonaceous Acetogenin Muricatetrocin C, D.J. Dixon, S.V. Ley and D. J. Reynolds, Angew. Chem., Int. Ed., 2000, 39, 3622.
418. Parallel Solution-phase synthesis of Functionalised Bicyclo [2.2.2]octanes: Generation of a Library using Orchestrated Multi-Step Sequences of Polymer Supported Reagents and Sequesterants S.V. Ley and A. Massi, J. Chem. Soc., Perkin Trans. 1, 2000, 3645.
417. Chemoenzymatic Synthesis of L-Galactosylated Dimeric Sialyl Lewis Structures Employing a-1,3-Fucosyltransferase V, A. Düffels, L.G. Green, R. Lenz, S.V. Ley, S. P. Vincent and C-H. Wong, Bioorg. Med. Chem., 2000, 8, 2519.
416. Combined Application of Analytical Techniques for the Characterisation of Polymer Supported Species P. Grice, A.G. Leach, S.V. Ley, A. Massi and D.M. Mynett, J. Combinatorial Chem., 2000, 2, 419.
415. The Use of π-Allyltricarbonyliron Lactone Complexes in the Synthesis of the Resorcylic Macrolides α- and β- Zearalenol S.V. Ley and S. Burckhardt, J. Chem. Soc., Perkin Trans. 1, 2000, 3028.
414. Polymer-Supported Reagents in Multi-Step Organic Synthesis: Application to the Synthesis of Sildenafil I.R. Baxendale and S.V. Ley, Bioorg. Med. Chem. Lett., 2000, 10, 1983.
413. Chemoenzymatic Synthesis of Sugar Fluorinated Nucleotide: Useful Mechanistic Probes for Glycosyltransferases the Glycosyltransferase Mechanism M.D. Burkart, S.P. Vincent, A. Düffels, B.W. Murray, S.V. Ley and C-H. Wong, Bioorg. Med. Chem., 2000, 8, 1937.
412. Polymer-Supported Reagents as Vesatile Tools in Combinatorial Chemistry and Total Synthesis G. Brusotti, M. Calderelli, J. Habermann, S.V. Ley and J. S. Scott, 4th International Electronic Conference on Synthetic Organic Chemistry, ECSOC 4, September 1-30, 2000.
411. Protecting Groups; Effects on Reactivity, Glycosylation, Stereoselectivity and Coupling Efficiency L.G. Green and S.V. Ley in “Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook”, Vol 1 ed. G. Hart, P. Sinäy and B. Ernst, Wiley-VCH, Weinheim, Germany 2000, 17, 427.
410. Diastereoselective Oxygen to Carbon Rearragements of Anomerically Linked Enol Ethers and the Total Synthesis of (+)-S,S-(cis-6-Methyltetrahydropyran-2-yl)acetic Acid a Component of Civet D.J. Dixon, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1, 2000, 2385.
409. Sweet Dreams: New Strategies and Methods for Complex Oligosaccharide Assembly S.V. Ley, Ernst Schering Research Foundation, Lecture Series, 2000, 37, 7. ISSN 1431-5033.
408. The Synthesis of Mono and Bicyclic Ethers via Acid Catalysed Ring-opening Cyclisation of Tetrahydropyranyl Ether Derivatives D.J. Dixon, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1, 2000, 1829.
407. Oxygen to Carbon Rearrangements of Anomerically Linked Alkenols from Tetrahydropyran Derivatives: An Investigation of the Reaction Mechanism via a Double Isotopic Labelling Crossover Study M.F. Buffet, D.J. Dixon, G.L. Edwards, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1, 2000, 1815.
406. A Short and Efficient, Stereoselective Synthesis of the Potent, Orally Active Anti-Histamine Agent CMI-977 D.J. Dixon, S.V. Ley, D.J. Reynolds and M. Chorgharde, Syn. Commun., 2000, 30, 1955.
405. 1,7- Asymmetric Induction of Chirality in a Mukaiyama Aldol Reaction using p-Allyltricarbonyliron Lactone Complexes: Highly Diastereoselective Synthesis of α-Substituted β-Hydroxy Carbonyl Compounds S.V. Ley and E.A. Wright, J. Chem. Soc., Perkin Trans. 1, 2000, 1677.
404. Tri-n-butyl [2-(trimethylsilyl)-ethoxymethoxymethyl] stannane: A Convenient Hydroxymethyl Anion Equivalent E. Fernández-Megia and S.V. Ley, Synlett, 2000, 455.
403. Synthesis of High-Mannose Type Neoglycolipids Active Targeting of Liposomes to Macrophages for Gene Therapy A. Düffels, L. G. Green, S.V. Ley and A.D. Miller, Chem. Eur. J., 2000, 6, 1416.
402. Methyl 2,3-O-(octahydro-6,6′-bi-2H-pyran-2,2′-diyl) a-D-galactopyranoside S.V. Ley and H.M.I. Osborn, Org. Synth., 2000, 77, 212.
401. Clean and Efficient Synthesis of Azo-Dyes using Polymer Supported Reagents M. Calderelli, I.R. Baxendale and S.V. Ley, Green Chemistry, 2000, 43.
400. Rapid Assembly of Oligosaccharides: 1,2-Diacetal Mediated Reactivity Tuning in the Coupling of Glycosyl Fluorides D.K. Baeschlin, L.G. Green, M.G. Hahn, S.J. Ince and S.V. Ley, TetrahedronAsymmetry, 2000, 11, 173.
399. Polymer Supported Reagents in Synthesis: Preparation of Bicyclo [2.2.2] octane Derivatives via Tandem Michael Addition Reactions and Subsequent Combinatorial Decoration S.V. Ley and A. Massi, J. Combinatorial Chem., 2000, 2, 104.
398. Use of the Temporary Connection in Organic Synthesis L.R. Cox and S.V. Ley in Templated Organic Synthesis. Ed F. Diederich and P.J. Stang Wiley-VCH, Weinheim, Germany, 2000, 275.
397. A Short and Efficient Steroselective Synthesis of the Polyhydroxylated Macrolactone (+)-Aspicilin D.J. Dixon, A.C. Foster and S.V. Ley, Org. Lett., 2000, 2, 123.
396. 1,2-Diacetals in Synthesis: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei D.K. Baeschlin, A.R. Chaperon, L.G. Green, M.G. Hahn, S.J. Ince, S.V. Ley, Chem. Eur.J., 2000, 6, 172.
395. Reductive Decomplexation of p-Allyltricarbonyliron Lactone Complexes: A New Route to Stereodefined Acyclic 1,5-Diols and 1,5,7-Triols S.V. Ley, S. Burckhardt, L.R. Cox and J.M. Worrall, J. Chem. Soc., Perkin Trans. 1, 2000, 211.
1999-1990
394. Structure activity relationships in azadirachtin A derivatives: feeding activity and degree of efficiency tested on Epilachna variestis larvae D.F. Hein, H.E. Hummel, S.V. Ley. Proceedings 51st International Symposium on Crop Protection, Gent, 1999, 64, 197. ISSN 0368-9697.
393. Synthesis of glycans from the glycodelins: two undeca-, two deca-, three nona-, and octa- and a heptasaccharide, D Depré, A. Düffels, L.G. Green, R. Lenz, S.V.Ley, C-H. Wong, Chem. Eur. J. 1999, 5, 3326-3340.
392. Highly cis– or trans– selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers D.J. Dixon, S.V. Ley, E.W. Tate, J. Chem. Soc., Perkin Trans. 1 1999, 2665-2667.
391. Modified mesoporous silicate MCM-41 materials: immobilised perruthenate: a new highly active hetergeneous oxidation catalyst for clean organic synthesis using molecular oxygen A. Bleloch, B.F.G. Johnson, S.V. Ley, A.J. Price, D.S. Shepherd, A.W. Thomas, J. Chem. Soc., Chem. Commun. 1999, 1907-1908.
390. The use of the potassium ion as a template for the selective derivatisation of the antibiotic X-206 A.C. O’Sullivan, F. Struber, S.V. Ley, J. Org. Chem. 1999, 64, 6252–6256.
389. Clean synthesis of α-bromo ketones and their utilization in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3- thiazoles using polymer supported reagents J. Habermann, S.V. Ley, J.S. Scicinski, J.S. Scott, R. Smits, A.W. Thomas, J. Chem. Soc., Perkin Trans. 1 1999, 2425-2427.
388. Three-step synthesis of an array of substitued benzofurans using polymer supported reagents J. Habermann, S.V. Ley, R. Smits, J. Chem. Soc., Perkin Trans. 1 1999, 2421-2423.
387. Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid D.J. Dixon, S.V. Ley, D.A. Longbottom, J. Chem. Soc., Perkin Trans. 1 1999, 2231-2232.
386. Chemistry of insect antifeedants from azadirachta indica (part 22): functionalisation of a decalin fragment of azadirachtin via a Claisen rearrangement reaction S.V. Ley, C.E. Gutteridge, A.R. Pape, C.D. Spilling, C. Zumbrunn, Synlett 1999, 1295-1297.
385. Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR Commentary by E. Fernández-Megía, S.V. Ley, Chemtracts, 1999, 539.
384. Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents M. Caldarelli, J. Habermann, S.V. Ley, Bioorg. Med. Chem. Lett. 1999, 9, 2049-2052.
383. Total synthesis of the cholesterol biosynthesis synthase inhibitor 1233A via a π-Allyltricarbonyliron Lactone Complex S.V. Ley, R.W. Bates, E. Fernández-Megía, S.V. Ley, K. Rück-Braun, D.M.G. Tilbrook, J. Chem. Soc., Perkin Trans. 1 1999, 1917-1926.
382. Dispiroketals in synthesis (Part 25): further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols M. Fujita, D. Lainé, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1999,1647-1656.
381. Dispiroketals in synthesis (part 24): preparation and use of chiral 2,2′-bis-(triisopropylsilyloxymethyl)bi(dihydropyrans) as new protecting and resolving agents for 1,2-diols D. Lainé, M. Fujita, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1999, 1639-1646.
380. A general and efficient procedure for the preparation of enantiopure anti-1,2-diols: synthesis and utility of (R‘,R‘,S,R)-2,3-butane diacetal protected butane tetrol D.J. Dixon, A.C. Foster, S.V. Ley, D. R. Reynolds, J. Chem. Soc., Perkin Trans. 1, 1999, 1635-1638.
379. Preparation of desymmetrised meso-tartrate derivatives: synthesis and utility of (R,R,S,S)-2,3-butane diacetals dimethyl tartrate D.J. Dixon, S.V. Ley, D.R. Reynolds, J. Chem. Soc., Perkin Trans. 1 1999, 1631-1634.
378. New building blocks for efficient and highly diastereoselective polyol production: synthesis and utility of (R,R,S,S)-and (S,S,R,R,)-2,3-butane diacetal protected butane tetrol derivatives J. Barlow, D.J. Dixon, A.C. Foster, S.V. Ley, D.R. Reynolds, J. Chem. Soc., Perkin Trans. 1 1999, 1627-1630.
377. Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents J. Habermann, S.V. Ley, J.S. Scott, J. Chem. Soc., Perkin Trans. 1, 1999, 1253-1256.
376. Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents S.V. Ley, O. Schucht, A.W. Thomas, P.J. Murray, J. Chem. Soc., Perkin Trans. 1, 1999, 1251-1252.
375. Total synthesis of the polyenoyl tetramic acid mycotoxin erythroskyrine D.J. Dixon, S.V. Ley, T. Gracza, P. Szolcsanyi, J. Chem. Soc., Perkin Trans. 1 1999, 839-842.
374. Polymer supported hypervalent iodine reagents in ‘clean’ organic synthesis with potential applications in combinatorial chemistry S.V. Ley, A.W. Thomas, H. Finch, J. Chem. Soc., Perkin Trans. 1 1999, 669-672.
373. Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives S.V. Ley and D. J. Dixon, Chemtracts, 1999, 12, 27.
372. Chemical synthesis of the N-glycans of Gp63 the major surface glycoprotein from Leishmania Mexicana amazonensis A. Düffels and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1999, 375-378.
371. Clean five-step synthesis of an array of 1,2,3,4,-tetra-substitued pyrroles using polymer supported reagents M. Caldarelli, J. Habermann, S. V. Ley, J. Chem. Soc., Perkin Trans. 1 1999, 107-110.
370. 1,7-Induction of chirality in Mukaiyama aldol reactions using π-allyltricarbonyliron lactone and lactam complexes as chiral templates S.V. Ley, L.R. Cox, B. Middleton, J.M. Worrall, Tetrahedron 1999, 55, 3515-3530.
369. Total synthesis of roflamycin, an oxopolyene macrolide antibiotic Commentary by S.V. Ley and P. Jones, Chemtracts, 1998, 11, 1005.
368. Assembly of dendritic glycoclusters from monomeric mannose building blocks P. Langer, S.J. Ince, S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 1998, 3913-3916.
367. Rapid assembly of oligosaccharides: total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei D.K. Baeschlin, A. Chaperon, V. Charbonneau, L.G. Green, S.V. Ley, U. Lücking, E. Walther, Angew. Chem., Int. Ed. Engl., 1998, 3423-3428.
366. Total synthesis of the protein phosphatase inhibitor okadaic acid S.V Ley, A C. Humphries, H. Eick, R. Downham, A.R. Ross, R.J. Boyce, J.B.J. Pavey, J. Pietruszka, J. Chem. Soc., Perkin Trans. 1 1998, 3907-3912.
365. Actions of azadirachtin, a plant allelochemical, against insects A. J. Mordue (Luntz), M. J. Simmonds, S. V. Ley, W. M. Blaney, W. Mordue, M. Nasiruddin, A. J. Nisbet, Pesticide Sci., 1998, 54, 277-284.
364. Double diastereodifferentiation in the Mukaiyama aldol reactions of π-allyltricarbonyliron lactone complexes; 1,7-vs 1,2-asymmetric induction S.V. Ley, L.R. Cox, J.M. Worrall, J. Chem. Soc., Perkin Trans. 1 1998, 3349-3354.
363. Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents J. Habermann, S.V. Ley, J.S. Scott, J. Chem. Soc., Perkin Trans. 1, 1998, 3127-3130.
362. A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement D.J. Dixon, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1 1998, 3125-3126.
361. Diastereoselective anomeric oxygen to carbon rearrangements of silyl enol ether derivatives of lactols D.J. Dixon, S.V. Ley, E.W. Tate, Synlett 1998, 1093-1095.
360. Anomeric oxygen to carbon rearragements of alkynyltributylstannane derivatives of lactols M. Buffet, D.J. Dixon, S.V. Ley, E.W. Tate, Synlett, 1998, 1091-1092.
359. A new route to functionalised π-allyltricarbonyliron lactam complexes from aziridines and their use in steroselective synthesis and oxidative conversion to β-lactams S.V. Ley and B. Middleton, J. Chem. Soc., Chem. Commun. 1998, 1995-1996.
358. Tricarbonyliron complexes: an approach to acyclic stereocontrol L.R. Cox and S.V.Ley, J. Chem. Soc. Rev. 1998, 27, 301-314.
357. Studies towards the synthesis of the C29-C51 fragment of altohyrtin A E. Fernadez-Megia, N. Gourlaouen, S.V. Ley, G.J. Rowlands, Synlett 1998, 991-994.
356. Steroelectronic effects in the reactions of conformationally restricted substituted cyclohexane 1,2-diones with 1,2-diols R. Lenz, S.V. Ley, D.R. Owen, S.L. Warriner, Tetrahedron Asymm. 1998, 2471-2480.
355. Synthesis of the acyltetronic and acid ionophore tetronasin (ICI M139603) S.V. Ley, D.S. Brown, J.A. Clase, H.M.I. Osborn, D. Wadsworth, E.S. Stokes, A.J. Fairbanks, J. Chem. Soc., Perkin Trans. 1,1998, 2259-2276.
354. Developement of a polymer bound Wittig reaction and use in multistep organic synthesis for the overall conversion of alcohols to β-hydroxyamines M. Bolli and S.V. Ley, J. Chem. Soc., Perkin Trans. 1,1998, 2243-2246.
353. Use of polymer supported reagents for clean multi-step organic synthesis: preparation of amines and amine derivatives from alcohols for use in compound library generation S.V. Ley, M. Bolli, B. Hinzen, A-G. Gervois, B.J. Hall, J. Chem. Soc., Perkin Trans. 1, 1998, 2239-2242.
352. Clean three step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents F.Haunert, M. Bolli and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 1998, 2235-2238.
351. Mukaiyama Aldol reactions of π-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains: not just formal but genuine 1,7-induction of chirality S.V. Ley, L.R. Cox, B. Middleton, J.M. Worrall, J. Chem. Soc., Chem. Commun. 1998, 1339-1340.
350. Polymer supported perruthenate (PSP): clean oxidation of primary alcohols to carbonyl compounds using oxygen as cooxidant B. Hinzen, R. Lenz, S.V. Ley, Synthesis 1998, 977-979.
349. One-pot synthesis of penta-and hepta-saccharides from monomeric mannose building blocks using the principles of orthogonality and reactivity tuning L. Green, B. Hinzen, S.J. Ince, P. Langer, S.V. Ley, S.L. Warriner, Synlett 1998, 440-442.
348. A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols S.V. Ley, S. Burckhardt, L.R. Cox and, J. M. Worrall, J. Chem. Soc., Chem. Commun., 1998, 229-230.
347. Highly diastereoselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes: a formal 1,7 asymmetric induction of chirality in a Mukaiyama Aldol reaction S.V. Ley and L.R. Cox, J. Chem. Soc., Chem. Commun. 1998, 227-228.
346. Synthesis of isoxazolidines using polymer supported perruthenate (PSP) B. Hinzen and S. V. Ley, J. Chem. Soc., Perkin Trans. 1 1998, 1-2.
345. Tuning glycoside reactivity: a new tool for efficient oligosaccharide synthesis N.L. Douglas, S.V. Ley, U. Lücking, S.L. Warriner, J. Chem. Soc., Perkin Trans. 1 1998, 51-66.
344. (1′S,2′S)-Methyl-3-0, 4-0-(1′,2′-dimethyoxycyclohexane-1′,2′-diyl)-a-d-mannopyranoside S.V. Ley, H.M.I. Osborn, H.W.M. Priepke, S.L. Warriner, Org. Synth. 1997, 75, 170.
343. 1,5 Asymmetric induction of chirality: diastereoselective addition of organoaluminium reagents and allylstannanes to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes S.V. Ley, S. Burckhardt, L.R. Cox, G. Meek, J. Chem. Soc., Perkin Trans. 1 1997, 3327-3338.
342. 1,5 Asymmetric induction of chirality: highly diastereoselective synthesis of homoallylic tertiary alcohols by the Lewis acid-mediated addition of allylstannanes into ketones in the side-chain of π-allyltricarbonyliron lactone complexes L.R. Cox and S.V. Ley, J. Chem. Soc., Perkin Trans. 11997, 3315-3326.
341. 1,5-Asymmetric induction of chirality: highly diastereoselective addition reactions of organoaluminium reagents into ketone groups in the side-chain of π-allyltricarbonyliron lactone complex S.V. Ley, L.R. Cox, G. Meek, K.-H. Metten, C. Pique, J. Worrall, J. Chem. Soc., Perkin Trans. 11997, 3299-3314.
340. Tetra-n-propylammonium perruthenate (TPAP)-catalysed oxidations of alcohols using molecular oxygen as a co-oxidant R. Lenz and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1997, 3291-3292.
339. Enantioselective aldol reactions of α-unsubstituted enol ether derivatives catalysed by a chiral Ti(IV) complex Liam R. Cox and S. V. Ley, Chemtracts, 1997, 10, 853.
338. Rapid access to rare natural pyranosides using 1,2-diacetal protected intermediates S.V. Ley, D.R. Owen, K.E. Wesson, J. Chem. Soc., Perkin Trans. 1 1997, 2805-2806.
337. A general C-glycosidation procedure via anomeric oxygen to carbon rearrangements of tetrahydropyranyl ether derivatives M.F. Buffet, D.J. Dixon, G.L. Edwards, S.V. Ley, E. Tate, Synlett1997, 1055.
336. Direct preparation of diacetals from 1,2 diketones and their use as 1,2-diol protecting groups A. Hense, S.V. Ley, H.M.I. Osborn, D.R. Owen, J.-F. Poisson, S.L. Warriner, K.E. Wesson, J. Chem. Soc., Perkin Trans. 1 1997, 2023-2032.
335. Polymer supported perruthenate (PSP): a new oxidant for clean organic synthesis B. Hinzen and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1997, 1907-1908.
334. Identification of azadirachtin in tissue-cultured cells of neem (Azadirachta indica) A.P. Jarvis, E.D. Morgan, S.A. van der Esch, F. Vitali, S.V. Ley, A.R. Pape, Nat. Prod. Lett. 1997, 10, 95-98.
333. Characterisation of azadirachtin binding to Sf9 nuclei in vitro A.J. Nisbet, A.J. Mordue (Luntz), R.B. Grossman, L. Jennens, S.V. Ley, W. Mordue, Arch. Insect Biochem and Physiol. 1997, 34, 461-473.
332. Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex S.V. Ley, G. Meek, J. Chem. Soc. Perkin Trans. 1 1997, 1125-1134.
331. One-pot synthesis of tetra- and pentasaccharides from monomeric building blocks using the principles of orthogonality and reactivity tuning M.-K. Cheung, N.L. Douglas, B. Hinzen, S V. Ley, X. Pannecoucke, Synlett 1997, 257-260.
330. Dispiroketals in synthesis. Part 23. A new route to (+)-D-conduritol B from myo-inositol J.E. Innes, P.J. Edwards, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1997, 795-796.
329. A new strategy for oligosaccharide assembly exploiting cyclohexane-1,2-diacetal methodology: an efficient synthesis of a high mannose type nonasaccharide P. Grice, S.V. Ley, J. Pietruszka, H.M.I. Osborn, H.W.M. Priepke, S.L. Warriner, Chem. Eur. J. 1997, 3, 431-440.
328. Preparation, Structure, Derivatisation and NMR Data of Cyclohexane 1,2-diacetal Protected Carbohydrates P. Grice, S.V. Ley, J. Pietruszka, H.W.M. Priepke, S.L. Warriner, J. Chem. Soc. Perkin Trans. 1 1997, 351-363.
327. Autoradiographic localization of [22,23-3h2] dihydroazadirachtin binding sites in desert locust testes and effect of azadirachtin on sperm mobility A.J. Nisbet, A.J. Mordue, L.M. Williams, L. Hannah, L. Jennens, S.V. Ley, W. Mordue, Tissue & Cell 1996, 28, 725-729.
326. Synthesis and chemistry of the ionophore antibiotic tetronasin S.V. Ley, J.A. Clase, D.J. Mansfield, H.M.I. Osborn, J. Heterocyclic Chem. 1996, 33, 1533-1544.
325. Efficient and general 1,5-acyclic stereocontrol: stereoselective synthesis of both cis and trans-2,6-disubstituted 5,6-dihydro-2H-pyrans and 5-alkoxy amino acid derivatives S. V. Ley and J. E. Innes, Chemtracts, 1996, 9, 204.
324. Direct protection of 1,2-diols from α-diketones N.L. Douglas, S.V. Ley, H.M.I. Osborn, D.R. Owen, H.W.M. Priepke, S.L. Warriner, Synlett 1996, 793-795.
323. Dispiroketals in synthesis (part 22): use of chiral bis-2,2′-(phenylthiomethyl)dihydropyrans as new protecting and resolving agents for 1,2 diols S.V. Ley, S. Mio, B. Meseguer, Synlett 1996, 791-793.
322. Dispiroketals in synthesis (part 21): use of chiral 2,2′-bis(halomethyl)dihydropyrans as new protecting and resolving agents for 1,2-diols S.V. Ley, S. Mio, Synlett 1996, 789-791.
321. Dispiroketals in synthesis (part 20): preparation of chiral bis-2,2′-(halomethyl) and 2,2 bis(phenylthiomethyl)dihydropyrans S.V. Ley, S. Mio, B. Meseguer, Synlett 1996, 787-788.
320. Chemistry of insect antifeedants from azadirachtin indica, (part 21): synthesis of model compounds of azadirachtin using a decalin framework as a functional group scaffolding M.-L. de la Puente, S.V. Ley, M.S.J. Simmonds and W. M. Blaney, J. Chem. Soc., Perkin Trans. 1, 1996, 1523-1529.
319. Chemistry of insect antifeedants from azadirachtin indica (part 20), synthesis of biologically active, simple analogues of azadirachtin containing the hydroxytetrahydrofurancarboxylate hemiketal moiety M.-L. de la Puente, S.V. Ley, R.B. Grossman, M.S.J. Simmonds, W.M. Blaney, J. Chem. Soc., Perkin Trans. 1 1996, 1517-1521.
318. Synthesis and chemistry of the ionophore antibiotic tetronasin S.V. Ley, J.A. Clase, D.J. Mansfield, Il Farmaco 1996, 51, 147-157.
317. Synthetic studies towards the clerodane insect antifeedant jodrellin a: preparation of a polycyclic model compound with antifeedant activity A. Cunat, D. Diez-Martin, S.V. Ley, F. Montgomery, J. Chem. Soc., Perkin Trans. 1 1996, 611-620.
316. Diastereoselective addition reactions of allylstannanes to carbonyl groups in the side-chain of π-allyltricarbonyliron lactone complexes S.V. Ley and L. Cox, J. Chem. Soc., Chem. Commun. 1996, 657-658.
315. π-Allyltricarbonyliron lactone complexes in organic synthesis: a useful and conceptually unusual route to lactones and lactams S.V. Ley, L.R. Cox, G. Meek, Chem. Rev. 1996, 96, 423-442.
314. Synthesis of the nonamannan residue of a high mannose glycoprotein P. Grice, S.V. Ley, J. Pietruszka, H.W.M. Priepke, Angew. Chem., Int. Edn. 1996, 35, 197-200.
313. Diastereoselective additions to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes S.V. Ley and G. Meek, J. Chem. Soc., Chem. Commun. 1996, 317-318.
312. Alkyl metals S.V. Ley and C. Kouklovsky, Chapter 2.11 in Comprehensive Organic Functional Group Transformations. Ed. A.R. Katritsky, O. Meth-Cohn, C.W. Rees, Pergamon, Oxford, 1995, 549-604.
311. Comprehensive organic functional group transformations Ed. A.R. Katritsky, O. Meth-Cohn, C.W. Rees, Pergamon, Oxford. S. V. Ley, Volume 2 Editor, 1995. ISBN 978-0-08-044705-6.
310. Rapid assembly of polycyclic alkaloids by asymmetric tandem cycloadditions of nitroalkenes S.V. Ley and C. E. Gutteridge, Chemtracts, 1995, 8, 222.
309. Tetra-n-propylammonium perruthenate in Encyclopedia of Reagents for Organic Synthesis S.V. Ley, J. Norman, A.J. Wilson. Ed. L. A. Paquette, J. Wiley and Sons 1995, Vol. 7, 4827-4830, DOI: 10.1002/047084289X.rt074.pub2.
308. Potassium ruthenate in Encyclopedia of Reagents for Organic Synthesis S.V. Ley and R. Leslie. Ed. L.A. Paquette, J. Wiley and Sons 1995, Vol. 6, 4282.
307. Barium manganate in Encyclopedia of Reagents for Organic Synthesis G. Procter, S.V. Ley, G.H. Castle. Ed. L.A. Paquette, J. Wiley and Sons 1995, Vol. 1, 240.
306. Dispiroketals: a new functional group for organic synthesis S.V. Ley, R. Downham, P.J. Edwards, J.E. Innes, M. Woods, Contemp. Org. Syn. 1995, 2, 365-392.
305. Spiroketal glycomimetics; the synthesis of a conformationally restrained sialyl Lewis X mimic A.A. Birkbeck, S.V. Ley, J.C. Prodger, Bioorg. Med. Chem. Lett. 1995, 5, 2637.
304. New chemistry of dispiroketals: ligands for asymmetric synthesis in Electronic Conference on Trends in Organic Chemistry G.H. Castle, J.E. Innes, S.V. Ley, ECTOC, June 1995.
303. Dispiroketals in synthesis (part 19): dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols R. Downham, P.J. Edwards, D.A. Entwistle, A.B. Hughes, K.-S. Kim, S.V. Ley, Tetrahedron Asymm. 1995, 6, 2403-2440.
302. Behavioural and neurophysiological responses of spodoptera littoralis to azadirachtin and a range of synthetic analogues M.S.J. Simmonds, W.M. Blaney, S.V. Ley, J.C. Anderson, R. Bänteli, A.A. Denholm, P. Green, R.B. Grossman, C. Gutteridge, L. Jennens, S.C. Smith, P.L. Toogood, A. Wood, Entomol. Exp. Appl. 1995, 77, 69.
301. Solid phase synthesis of bicyclo [2.2.2] octane derivatives via tandem michael addition reactions and subsequent reductive amination S.V. Ley, D. Mynett, W.-J. Koot, Synlett 1995, 1017-1020.
300. Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of side-chain carbonyl group of a π-allyltricarbonyliron lactone complex S.V. Ley and G. Meek, J. Chem. Soc., Chem. Commun. 1995, 1751-1752.
299. Dispiroketals in synthesis (part 18): regioselective and enantioselective protection of symmetrical polyol substrates using an enantiopure (2s,2′s)-dimethyl-bis-dihydropyran P.J. Edwards and S.V. Ley, Synlett 1995, 898.
298. Behavioural responses of locusts and spodoptera littoralis to azadirachtin and azadirachtin analogues containing fluorescent and immunogenic reporter groups M.S.J. Simmonds, W.M. Blaney, R.B. Grossman, S.V. Ley, J. Insect Physiol. 1995, 41, 555.
297. Tuning the reactivity of glycosyl donors: efficient one-pot oligosaccharide synthesis P. Grice, S.V. Ley, J. Pietruszka, H.W.M. Priepke, E.P.W. Walther, Synlett 1995, 781.
296. Regiospecific fragmentation of benzene derivatives: synthetic and analytical applicationsN.J. Hales, H. Heaney, J.H. Hollinshead, S.V. Ley, Tetrahedron 1995, 51, 7755.
295. The synthesis and assay of radiolabelled benzene derivatives N.J. Hales, H. Heaney, J.H. Hollinshead, S.V. Ley, Tetrahedron 1995, 51, 7741.
294. Dispiroketals in synthesis (part 16), functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form and their application as bifunctional C2-symmetrical chiral auxiliaries for highly stereoselective michael additions B.C.B. Bezuidenhoudt, G.H. Castle, J.E. Innes, S.V. Ley, Recl. Trav. Chim. Pays-Bas, 1995, 114, 184.
293. Chemistry of insect antifeedants from azadirachta indica (part 19): a potential relay route for the synthesis of azadirachtin A.A. Denholm, L. Jennens, S.V. Ley, A. Wood, Tetrahedron 1995, 51, 6591.
292. Biosynthesis of tetronasin (part 4), preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI M139 603) G.-J. Boons, J.A. Clase, I.C. Lennon, S.V. Ley, J. Staunton, Tetrahedron 1995, 51, 5417.
291. Chemistry of insect antifeedants from azadirachta indica (part 18): demethylation and methylation of the C-8 position of the decalin portion of azadirachtin W.-J. Koot and S. V. Ley, Tetrahedron 1995, 51, 2077.
290. Sexual Development of Malaria Parasites is Inhibited in vivo by the Neem Extract Azadirachtin and its Semi-synthetic Analogues I.W. Jones, A.A. Denholm, S.V. Ley, H. Lovell, A. Wood and R.E. Sinden, FEMS Microbiol Lett. 1994, 120, 267.
289. Dispiroketals in Synthesis (Part 17): Regioselective Protection of D-Glucopyranoside, D-Galactopyranoside and D-Mannopyranoside Substrates P.J. Edwards, D.A. Entwistle, C. Genicot, S.V. Ley and G. Visentin, Tetrahedron Asymmetry, 1994, 5, 2609.
288. Dispiroketals in Synthesis (Part 15): Simultaneous Protection and Enantioselective Desymmetrisation of Glycerol by Reaction with a C2-Symmetric Dimethyl bis-Dihydropyran C. Genicot and S.V. Ley, Synthesis, 1994, 1275.
287. A Facile One-pot Synthesis of a Trisaccharide Unit from the Common Polysaccharide Antigen of the Group B Streptococci using Cyclohexane-1,2-diacetal Protected Rhamnosides S.V. Ley and H.W.M. Priepke, Angew. Chem., Int. Ed. Engl. 1994, 33, 2292.
286. Cyclohexane-1,2-diacetals (CDA): A New Vicinal Diol Protecting Group for Carbohydrates S.V. Ley, H.W.M. Priepke and S.L. Warriner, Angew. Chem., Int. Ed. Engl. 1994, 33, 2290.
285. Connectivist approach to organic structure prediction: LSD-program assisted NMR analysis of the insect antifeedant azadirachtin S.V. Ley, K. Doherty, G. Massiot and J.-M. Nuzillard, Tetrahedron, 1994, 50, 12267.
284. Dispiroketals in synthesis (part 14): functionalized dispiroketals as new chiral auxiliaries; highly stereoselective michael additions to a bifunctional C2-symmetrical chiral auxiliary G.H. Castle and S.V. Ley, Tetrahedron Lett. 1994, 35, 7455.
283. Dispiroketals in synthesis (part 13): functionalized dispiroketals as new chiral auxiliaries; highly stereoselective diels-alder reactions using a bifunctional C2-symmetrical chiral auxiliaryB.C.B. Bezuidenhoudt, G.H. Castle J.V. Geden and S.V. Ley, Tetrahedron Lett. 1994, 35, 7451.
282. Dispiroketals in synthesis (part 12): functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form B.C.B. Bezuidenhoudt, G.H. Castle and S.V. Ley, Tetrahedron Lett. 1994, 35, 7447.
281. Dispiroketals in synthesis (part 11): concomitant enantioselective and regioselective protection of symmetrical 2,5-dibenzoyl-myo-inositol P.J. Edwards, D.A. Entwhistle, C. Genicot, K-S Kim and S.V. Ley, Tetrahedron Lett. 1994, 35, 7443.
280. Synthesis and chemistry of the insect antifeedant azadirachtin (S. Saddiqui Lecture) S.V. Ley, Pure and Appl. Chem. 1994, 66, 2099.
279. Chemistry of insect antifeedants from azadirachta indica (part 17): synthesis of model compounds of azadirachtin. Unusual effect of remote substituents on the course of the oxidative ring contraction reaction R.B. Grossman and S.V. Ley, Tetrahedron, 1994, 50, 11553.
278. Diastereoselective addition reactions to carbonyl groups in the side-chain of p-allyltricarbonyliron lactone complexes S.V. Ley, G. Meek, K-H Metten, C. Pique, J. Chem. Soc., Chem. Commun. 1994, 1931.
277. Chemistry of insect antifeedants from azadirachta indica (part 16): synthesis of several derivatives of azadirachtin containing fluorescent or immunogenic reporter groups R.B. Grossman and S.V. Ley, Tetrahedron, 1994, 50, 8871.
276. Tetrapropylammonium perruthanate, Pr4N+RuO4- TPAP: a catalytic oxidant for organic synthesis S.V. Ley, S.P. Marsden, J. Norman, W.P. Griffith, Synthesis, 1994, 639.
275. Model studies towards the insect antifeedant jodrellin a using an organoselenium mediated cyclization reaction W.M. Blaney, A.C. Curyat, S.V. Ley, F.J. Montgomery, M.S.J. Simmonds, Tetrahedron Lett. 1994, 35, 4861.
274. Tricarbonyliron lactone complexes in organic synthesis S.V. Ley, Pure and Appl. Chem. 1994, 66, 1415.
273. Dispiroketals in synthesis (part 10): further reactions of dispoke protected lactate and glycolate enolates G.-J. Boons, R. Downham, K.S. Kim, S.V. Ley, M. Woods, Tetrahedron, 1994, 50, 7157.
272. Dispiroketals in synthesis (part 9): resolution of 1,2-diols using a C2-symmetric diphenyltetrahydrobipyran P.J. Edwards, D.A. Entwistle, S.V. Ley, D.R. Owen, E.J. Perry, Tetrahedron Asymmetry, 1994, 5, 553.
271. Studies towards the total synthesis of rapamycin: preparation of the C10-C17 carbon unitS.V. Ley, J. Norman, C. Pinel Tetrahedron Lett. 1994, 35, 2095.
270. Studies towards the total synthesis of rapamycin: preparation of the cyclohexyl C33-C42 fragment and further coupling to afford the C22-C42 carbon unit C. Kouklovsky, S.V. Ley, S.P. Marsden Tetrahedron Lett., 1994, 35, 2091.
269. Studies towards the total synthesis of rapamycin: a convergent and stereoselective synthesis of the C22-C32 carbon framework J.C. Anderson, S.V. Ley, S.P. Marsden Tetrahedron Lett. 1994, 35, 2087.
268. Effect of azadirachtin-derived decalin (perhydrophthalene) and dihydrofuranacetal (furo[2,3-b] pyran) fragments on the feeding behaviour of Spodoptera Littoralis W.M. Blaney, M.S.J. Simmonds, S.V. Ley, S.C. Smith, A. Wood, Pestic. Sci., 1994, 40, 169.
267. Towards the synthesis of the C37-C42 fragment of rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from a-alkoxy sulfones S.V. Ley and C. Kouklovsky Tetrahedron, 1994, 50, 835.
266. Dispiroketals in synthesis (part 8): regioselective protection of D-glucopyranose substratesD.A. Entwistle, A.B. Hughes, S.V. Ley, G. Visentin, Tetrahedron Lett. 1994, 35, 777.
265. Dispiroketals in synthesis (part 7): protection of D-glucopyranose substrates A.B. Hughes, S.V. Ley, H.W.M. Priepke, M. Woods, Tetrahedron Lett. 1994, 35, 773.
264. Dispiroketals in synthesis (part 6): highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates R. Downham, K.S. Kim, S.V. Ley, M. Woods, Tetrahedron Lett.1994, 35, 769.
263. Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603) G.-J. Boons, I.C. Lennon, S.V. Ley, E.S.E. Owen, J. Staunton, D.J. Wadsworth, Tetrahedron Lett., 1994, 35, 323.
262. Two new routes to the C19-C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI, M139603) G.-J. Boons, D.S. Brown, J.A. Clase, I.C. Lennon, S.V. Ley, Tetrahedron Lett. 1994, 35, 319.
261. Biosynthesis of tetronasin: part 3. Preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin H.C. Hailes, S. Handa, P.F. Leadlay, I.C. Lennon, S.V. Ley, J. Staunton, Tetrahedron Lett. 1994, 35, 315.
260. Biosynthesis of tetronasin: part 2. Identification of the tetraketide intermediate attached to the polyketide synthase H.C. Hailes, S. Handa, P.F. Leadlay, I.C. Lennon, S.V. Ley, J. Staunton, Tetrahedron Lett. 1994, 35, 311.
259. Biosynthesis of tetronasin: part 1. Introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase H.C. Hailes, C.M. Jackson, P.F. Leadlay, S.V. Ley, J. Staunton, Tetrahedron Lett. 1994, 35, 307.
258. Dispiroketals in synthesis (part 5): a new opportunity for oligosaccharide synthesis using differentially activated glycosyl donors and acceptors G.-J. Boons, P. Grice, R. Leslie, S.V. Ley and L.-L. Yeung, Tetrahedron Lett. 1993, 34, 8523.
257. Uptake, retention, metabolism and excretion of [22,23-3H2]-dihydroazadirachtin in Schistocerca Gregaria P.A. Paranagama, R.H.C. Strang, J.D. Connolly, S.V. Ley, A.A. Denholm, H. Lovell, Insect Physiol. 1993, 39, 935.
256. Selective acylation and alkylation reactions of diols using dibutyltin dimethoxide G.H. Castle, J.A. Clase, G.-J. Boons, P. Grice, S.V. Ley, C. Pinel, Synlett, 1993, 913.
255. Total synthesis of the spiroketal macrolide (+)-milbemycin a1 S. V. Ley, A. Madin and N. Monck, Tetrahedron Lett. 1993, 34, 7479.
254. Microwave promoted hydrolysis of esters absorbed on alumina. a new deprotection method for pivaloyl groups, S.V. Ley and D. M. Mynett, Synlett, 1993, 793.
253. Synthesis of 4-substituted imidazoles via 4-metallo imidazole intermediates R.M. Turner, S.V. Ley, S.D. Lindell, Synlett, 1993, 748.
252. Dispiroketals in synthesis (part 4): enantioselective desymmetrization of glycerol using a C2-symmetric disubstituted bis-dihydropyran G.-J. Boons, D. A. Entwistle, S. V. Ley and M. Woods Tetrahedron Lett. 1993, 34, 5649.
251. Dispiroketals in synthesis (part 3): selective protection of diequatorial vicinal diols in carbohydrates G.-J. Boons, R. Leslie, S.V. Ley, M. Woods, D.M. Hollinshead, Synthesis, 1993, 689.
250. Diastereoselective and enantioselective formation of quaternary carbon centres via the intramolecular heck reaction: the influence of the coordination state of the palladium catalyst S.V. Ley and S.P. Marsden, Chemtracts, 1993, 23.
249. Some alkylation and reductive amination studies of b-ketomacrolides as potential metal speciation materials S.V. Kelkar and S.V. Ley, Heterocycles, 1993, 35, 263.
248. The chemistry of azadirachtin, S.V. Ley, A.A. Denholm, A. Wood, Nat. Prod. Rep. 1993, 109.
247. Chemistry of insect antifeedants from azadirachta indica (part 15): degradation studies of azadirachtin leading to C8-C14 bond cleavage S.V. Ley, P.J. Lovell, A.M.Z. Slawin, S.C. Smith, D.J. Williams, A. Wood, Tetrahedron, 1993, 49, 1675.
246. Synthesis of insect antifeedants S.V. Ley, J. Synth. Org. Chem. 1992, 50, 1109.
245. Luminescence dynamics and 13C NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs K.D. Matthews, S.A. Bailey-Folkes, I.A. Kahwa, G.L. McPherson, C.A. O’Mahoney, S.V. Ley, D.J. Williams, C.J. Groombridge, C.A. O’Connor, J. Phys. Chem. 1992, 96, 7021.
244. Microbial oxidation in synthesis: preparation of a potential insulin mimic from benzene S.V. Ley and L.L. Yeung, Synlett, 1992, 997.
243. Enabling methodology: the synthetic chemists contribution to molecular recognition S. V. Ley and L. L. Yeung, Royal Society of Chemistry, Special Publication, 1992, 111, 183.
242. Immobilization of thallium by tandem oxidation/reduction-complexation of thallium (I/III) I.A. Kahwa, D. Miller, M. Mitchel, F.R. Fronczek, R.G. Goodrich, D.J. Williams, C.A. O’Mahoney. A.M.Z. Slawin, S.V. Ley, C.J.Groombridge, Inorg. Chem. 1992, 31, 3963.
241. Chemistry of insect antifeedants from Azadirachta indica (part 14): absolute configuration of azadirachtin S.V. Ley, H. Lovell, D.J. Williams, J. Chem. Soc., Chem. Commun. 1992, 1304.
240. Chemistry of insect antifeedants from Azadirachta indica (part 13): on the use of the intramolecular diels-alder reaction for the construction of trans-fused hydrobenzofuran fragments for azadirachtin synthesis H.C. Kolb, S.V. Ley, R.N. Sheppard, A.M.Z. Slawin, S.C. Smith, D.J. Williams, A. Wood, J. Chem. Soc., Perkin Trans. 1, 1992, 2763.
239. Chemistry of insect antifeedants from Azadirachta indica (part 12): use of silicon as a control element in the synthesis of a highly functionalised decalin fragment of azadirachtin H.C. Kolb, S.V. Ley, A.M.Z. Slawin and D.J. Williams, J. Chem. Soc., Perkin Trans. 1, 1992, 2735.
238. Total synthesis of ionophore antibiotic CP-61,405 (routiennocin) D. Díez-Martin, N.R. Kotecha, S.V. Ley, S. Mantegani, J.C. Menéndez, H.M. Organ, A.D. White, B.J. Banks, Tetrahedron, 1992, 48, 7899.
237. Dispiroketals in synthesis (part 2): a new group for the selective protection of diequatorial vicinal diols in carbohydrates S.V. Ley, R. Leslie, P.D. Tiffin, M. Woods, Tetrahedron Lett. 1992, 33, 4767.
236. Oxidation of activated halides to aldehydes and ketones by N-methylmorpholine-N-oxide, W.P. Griffith, J.M. Jollife, S.V. Ley, P.D. Tiffen and K.F. Springhorn, Syn. Commun. 1992, 22, 1967.
235. New routes to biologically active heterocyclic natural products S.V. Ley, Bull. Soc. Chim. Belg. 1992, 101, 641.
234. Clerodane diterpenoids A. Merritt and S.V. Ley, Nat. Prod. Rep. 1992, 243.
233. Further reactions of t-butyl 3-oxobutanthioate and t-butyl 4-diethylphosphono-3-oxobutanthioate: carbonyl coupling reactions, amination, use in the preparation of the 3-aceyltetramic acids and application to the total synthesis of fuligorubin A S.V. Ley, S.C. Smith, P.R. Woodward, Tetrahedron, 1992, 48, 1145.
232. Total synthesis of the carboxylic acid ionophore antibiotic CP-61,405 (routiennocin): preparation of the inherent spiroketal unit via a reverse coupling process D. Diez-Martin, N.R. Kotecha, S.V. Ley, J.C. Menendez, Synlett, 1992, 399.
231. Total synthesis of the carboxylic acid ionophore antibiotic CP-61,405 (routiennocin) N.R. Kotecha, S.V. Ley, S. Mantegani, Synlett, 1992, 395.
230. Microbial oxidation in synthesis: preparation of pseudo-alpha-D-glycopyranose from benzene L. L. Yeung and S.V. Ley, Synlett, 1992, 291.
229. Dispiroketals in synthesis: preparation of a stable, sterically demanding glyceraldehyde ketal and diasteroselective reactions with simple Organometallic reagents S.V. Ley, M. Woods, A. Zanotti-Gerosa, Synthesis, 1992, 52.
228. Synthesis of the alkaloids (−)-heliotridane and (−)-isoretronecanol via π-allyltricarbonyliron lactam complexes G. Knight and S.V. Ley, Tetrahedron Lett. 1991, 32, 7119.
227. Oxidation of activated C-H bonds adjacent to heteroatoms: oxidation adjacent to oxygen of alcohols by chromium reagents by S.V. Ley and A. Madin in Comprehensive Organic Synthesis. Pergamon Press, 1991, 7, 251. ISBN 0080359299, 9780080359298
226. Comprehensive organic synthesis Eds. B.M. Trost and I. Fleming, Vol 7 Oxidation, S.V. Ley, Pergamon Press, Oxford UK, 1991. ISBN 0080359299, 9780080359298
225. The use of p-allyltricarbonyliron lactone complexes in the synthesis of b-lactone esterase inhibitor (–)-valilactone R.W. Bates, R. Fernández-Moro and S.V. Ley, Tetrahedron, 1991, 47, 9929.
224. Chemistry of insect antifeedants from azadirachta indica (part 11): characterisation and structure activity relationships of some novel rearranged azadirachtins S.V. Ley, J.C. Anderson, W.M. Blaney, E.D. Morgan, R.N. Sheppard, M.S.J. Simmonds, A.M.Z. Slawin, S.C. Smith, D.J. Williams, A. Wood, Tetrahedron, 1991, 47, 9231.
223. A facile route to imidazole-4-yl anions and their reactions with carbonyl compounds R.N. Turner, S.D. Lindell, S.V. Ley, J. Org. Chem. 1991, 56, 5739.
222. The Champagne Route to Avermectins and Milbemycins in Strategy and Tactics in Organic Synthesis Vol. 3, S.V. Ley and A. Armstrong, T. Lindberg, Ed. Acad. Press, 1991, 273-291. ISBN-13 : 978-0080924304.
221. The total synthesis of agglomerin a and (±)-carolinic acid: a general method for the preparation of 3-acyl tetronic acids via direct acylation of o-methyl 3- stannyl tetronates S.V. Ley, M.L. Trudell, D.J. Wadsworth, Tetrahedron, 1991, 47, 8285.
220. Chemistry of insect antifeedants from azadirachta indica (part 10): synthesis of a highly functionalised decalin fragment of azadirachtin H.C. Kolb and S.V. Ley, Tetrahedron Lett. 1991, 32, 6187.
219. Chemistry of insect antifeedants from azadirachta indica (part 9): oxidative reactions of azadirachtin derivatives, leading to c8-c14 bond cleavage S.V. Ley, P.J. Lovell, S.C. Smith, A. Wood, Tetrahedron Lett. 1991, 32, 6183.
218. Microbial oxidation in synthesis: preparation of novel 3-substituted cis- cyclohexa-3,5-diene-1,2-diol derivatives from (1s,2s)-3-bromocyclohexa-3,5- diene-1,2-diol S.V. Ley, A.J. Redgrave, S.C. Taylor, S. Ahmed, D.W. Ribbons, Synlett, 1991, 741.
217. Novel routes to inositol phosphates using Pseudmonas putida oxidation of arenes S.V. Ley, A.J. Redgrave, L-L. Yeung, ACS. Symposium Series, 1991, 463, 132 A.B. Reitz Editor, ISBN 0-8412-2086-7.
216. Organic reactions Eds. P. Beak, E. Ciganek, S. Hanessian, L. Hegedus, R.C. Kelly, S.V. Ley, L.E. Overman, L.A. Paquette, H.J. Reich, C. Sih, A.B. Smith III, M. Uskokovic, Vol. 40, 1991, ISBN: 0-471-53841-8, J. Wiley, New York.
215. Substitution reactions of 2-benzenesulfonyl cyclic ethers: tetrahydro-2-(phenylethynyl)-2H-pyran D.S. Brown and S.V. Ley, Organic Syntheses, 1991, 70, 157.
214. New methods for natural product synthesis by S.V. Ley 1991, 55. Conferencias Plenarias de la XXIII Reunion Bienal de Química, Ed. A. San Feliciano, M. Grande and J. Casado, Salamanca, September 23-29, 1991, 55. ISBN 84-404-9763-6.
213. Chemistry of insect antifeedants from azadirachta indica (part 8): synthesis of hydroxydihydrofuran acetal fragments for biological evaluation and azadirachtin total synthesis studies J.C. Anderson, S.V. Ley, D. Santafianos, R.N. Sheppard, Tetrahedron, 1991, 47, 6813.
212. Synthesis of antifeedants. S.V. Ley, Pesticide Chemistry 1991, 97, Ed. H. Frehse, (VCH, Weinheim), ISBN 3-527-28111-8.
211. Use of phenylsulphonylmethano ethers in synthesis: a new versatile route to substituted cyclic ethers P. Charreau, S.V. Ley, T.M. Vettiger, S.Vile, Synlett, 1991, 415.
210. Total synthesis of the anthelmintic macrolide avermectin B1a S.V. Ley, A. Armstrong, D. Díez-Martín, M.J. Ford, P. Grice, J. Knight, H.C. Kolb, A. Madin, C.A. Marby, S. Mukherjee, A.N. Shaw, A.M.Z. Slawin, S. Vile, A.D. White, D.J. Williams, M.Woods, J. Chem. Soc., Perkin Trans. 1 1991, 667-692.
209. Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes R.W. Bates, R. Fernández-Moro, S.V. Ley, Tetrahedron Lett.1991, 32, 2651.
208. Use of 2-phenylsulphonyl cyclic ethers in the preparation of tetrahydropyran and tetrahydrofuran acetals and in some glycosidation reactions D.S. Brown, S.V. Ley, S. Vile, M. Thompson, Tetrahedron, 1991, 47, 1329.
207. Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids norruspoline and ruspolinone D.S. Brown, P. Charreau, T. Hansson, S.V. Ley, Tetrahedron, 1991, 47, 1311.
206. Synthesis of tetrahydropyran containing natural products by S.V. Ley in Heterocycles in Bioorganic Chemistry Eds. J. Bergman, H.C. Van der Plas, M. Simonyi, Royal Society of Chemistry, London, 1991. ISBN-0-85186-877-0.
205. Synthesis of hydropyran containing natural products by S.V. Ley in New Methods in Drug Research. 1990. Ed. A. Makriyannis. Prous Science, Barcelona, Spain, Vol 3, 1990. ISBN 84-86973-14-7.
204. Organic reactions R.C. Kelly, S.V. Ley, L.E. Overman, H.J. Reich, C.J.Sih, A.B. Smith III, M. Uskakovic, L.A. Paquette, P. Beak, E. Ciganek, S. Hanessian, L. Hegedus, Vol. 39, 1990.
203. Organic reactions R.C. Kelly, S.V. Ley, L.E. Overman, H.J. Reich, C.J.Sih, A.B. Smith III, M. Uskakovic, L.A. Paquette, P. Beak, E. Cizanek, S. Hanessian, L. Hegedus, Vol. 38, 1990.
202. An efficient three step synthesis of L(-)-oleandrose from S(-)-methyl lactate M.J. Ford and S.V. Ley, Synlett, 1990, 771.
201. Direct substitution of 2-phenylsulphonyl pyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by alkylorganometallic reagents in dichloromethane D.S. Brown, P. Charreau, S.V. Ley, Synlett, 1990, 749.
200. Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants S.V. Ley, Bioactive Compounds from Plants, J.Wiley, Chichester, UK.[Ciba Foundation Symposium 154] 1990, 80.
199. Organic reactions A.S. Kende, E.Ciganek, H.W. Gschwend, S. Hanessian, S.V.Ley, L.E. Overman, L.A. Paquette, G.H. Posner, H.J. Reich, Vol. 37, 1989.
198. Organic reactions A.S. Kende, E. Ciganek, S. Danishefsky, H.W. Gschwend, S. Hanessian, S.V. Ley, L.E. Overman, L.A. Paquette, G.H. Posner, H.J. Reich, M. Semmelhack, Vol. 36, 1988.
197. Organic reactions A.S. Kende, E. Ciganek, S. Danishefsky, H.W. Gschwend, S. Hanessian, S.V. Ley, L.E. Overman, L.A. Paquette, G.H. Posner, H.J. Reich and M. Semmelhack, Vol. 35, 1988.
196. A new ruthenium(VI) oxidant: preparation, x-ray crystal structure and properties of (Ph4P)[RuO2(OAc)Cl2] W.P. Griffith, J.M. Jolliffe, S.V. Ley and D.J. Williams, J. Chem. Soc., Chem. Commun., 1990, 1219.
195. Stereoselective synthesis of inositol phosphates S.V. Ley, Pure and App. Chem. 1990, 62, 2031.
194. Synthesis of the C12-C26 fragment of the acyltetronic acid ionophore antibiotic tetronasin (ICI 139603) S.E. deLaszlo, M.J. Ford, S.V. Ley, G.N. Maw, Tetrahedron Lett. 1990, 31, 5525.
193. Enantioslective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ICI 139603) S.V. Ley, G.N. Maw and M.L. Trudell, Tetrahedron Lett. 1990, 31, 5521.
192. Azadirachtin: structural requirement for reducing growth and increasing mortality in Lepidopterous larvae M.S.J. Simmonds, W.M. Blaney, S.V. Ley, J.C. Anderson and P.L. Toogood, Entomol. Exp. Appl. 1990, 55, 169.
191. Antifeedant effects of azadirachtin and structurally related compounds on Lepidopterous Larvae W.M. Blaney, M.S.J. Simmonds, S.V. Ley, J.C. Anderson, P.L. Toogood, Entomol. Exp. Appl. 1990, 55, 149.
190. Microbial oxidation in synthesis: concise preparation of (+)-conduritol F from benzene S.V. Ley and A.J. Redgrave, Synlett, 1990, 393.
189. Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene S.V. Ley, M Parra, A.J. Redgrave, F. Sternfeld, Tetrahedron, 1990, 46, 4995.
188. Total synthesis of avermectin B1a: synthesis of the carbohydrate bis-oleandrose fragment and coupling to the avermectin B1a aglycone M.J. Ford, J.G. Knight, S.V. Ley and S.Vile, Synlett 1990, 331-3.
187. Total synthesis of avermectin B1a: final coupling reactions and the total synthesis of avermectin B1a aglycone A. Armstrong, S.V. Ley, A. Madin, S. Mukherjee, Synlett 1990, 328-330.
186. Total synthesis of avermectin B1a: synthesis of the C11-C25 spiroacetal fragment D. Díez-Martín, P. Grice, H.C. Kolb, S.V. Ley, A. Madin, Synlett 1990, 326-328.
185. Total synthesis of avermectin B1a: Planning of the synthesis and preparation of the C1-C10 “southern” hydrobenzofuran fragment A. Armstrong and S.V. Ley, Synlett 1990, 323-325.
184. Synthesis of a C16-C23 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a D. Diez- Martin, P. Grice, H. C. Kolb, S.V. Ley, A. Madin, Tetrahedron Lett. 1990, 31, 3445-3448.
183. Chemistry of insect antifeedants from azadirachta indica (part 7): preparation of an optically pure hydroxacetal epoxide related to azadirachtin J.C. Anderson and S.V. Ley, Tetrahedron Lett. 1990, 31, 3437.
182. Neo-clerodane insect antifeedants from Scutellaria Galericulata M.D. Cole, J.C. Anderson, W.M. Blaney, L.E. Fellows, S.V. Ley, R.N. Sheppard, M.S.J. Simmonds, Phytochemistry, 1990, 29, 1793.
181. Assessment of butene-1,4-diols as starting materials for the preparation of p-allyltricarbonyliron lactone complexes R.W. Bates, D. Diez-Martin, W.J. Kerr. J.G. Knight, S.V. Ley And A. Sakellaridis, Tetrahedron, 1990, 46, 4063.
180. A simple one-pot, glycosidation procedure via (1-imidazoylcarbonyl) glycosides and zinc bromide M.J. Ford and S.V. Ley, Synlett, 1990, 255.
179. TPAP: tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols W.P. Griffith and S.V. Ley, Aldrichimica Acta, 1990, 23, 13-19.
178. Alkenylcyclic sulphites as novel precursors for the preparation of pi-allyltricarbonyliron lactone complexes M. Caruso, J.G. Knight and S.V. Ley, Synlett, 1990, 224.
177. Recent advances in the chemistry of insect control II Ed. L. Crombie, Royal Society of Chemistry Special Publication No. 79, in Synthesis and Modification of Azadirachtin and Related Antifeedants. S.V. Ley, 1990, 90. ISBN 0851866271 (pbk) :9780851866277 (pbk)
176. Chemistry of insect antifeedants from azadirachta indica (part 6): synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirchtin and novel antifeedants J.C. Anderson and S.V. Ley, Tetrahedron Lett. 1990, 31, 431.
175. Direct substitution of 2-benzenesulphonyl-piperidines and -pyrrolidines by carbon nucleophiles: synthesis of the pyrrolidine alkaloid ruspolinone D.S. Brown, T. Hansson and S.V. Ley, Synlett, 1990, 48.
174. Insect antifeedants S.V. Ley and P.L. Toogood, Chemistry in Brit. 1990, 26, 31.
Pre-1990
173. Preparation of β-ketomacrolactones and β-ketodiolides using S–t-butyl 3-oxobutanethioate and S–t-butyl 4-diethylphosophono-3-oxobutanethioate P.M. Booth, H.B. Broughton, M.J. Ford, C.M.J. Fox, S.V. Ley, A.M.Z. Slawin, D.J. Williams, P.R. Woodward, Tetrahedron 1989, 45, 7565-7580.
172. A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycin b1 S.V. Ley, N.J. Anthony, A. Armstrong, M.G. Brasca, T. Clarke, C. Greck, P. Grice, A.B. Jones, B. Lygo, A. Madin, R.N. Sheppard, A.M.Z. Slawin, D.J. Williams, Tetrahedron 1989, 45, 7161-7194.
171. The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal-metal pair interactions I.A. Kahwa, S. Folkes, D.J. Williams, S.V. Ley, C.A. O’Mahoney, G.L. McPherson, J. Chem. Soc., Chem. Commun. 1989, 1531-1533.
170. Ultrasound in synthesis, reactivity and structure concepts in organic chemistry, Vol. 27, Verlag, Berlin, Heidelberg, New York, 1989, ISBN 3-540-51023-0.
169. The structure of two new clerodane diterpenoid potential insect antifeedants from Scutellaria woronowii (Juz); jodrellin A and B J.C. Anderson, W.M. Blaney, M.D. Cole, L.E. Fellows, S.V. Ley, R.N. Sheppard, M.S.J. Simmonds, Tetrahedron Lett. 1989, 30, 4737-4740.
168. The chemistry of the neem tree P.S. Jones, S.V. Ley, E.D. Morgan, D. Santafianos in Phytochemical Pesticides. Ed. M. Jacobson, CRC Press Inc., Boca Raton Florida, Vol 1, 1989, 19-45.
167. Insect antifeedants from Azadirachta indica (Part 5): chemical modification and structure-activity relationships of azadirachtin and some related limonoids S.V. Ley, J.C. Anderson, W.M. Blaney, Z. Lidert, E.D. Morgan, P.S. Jones, N.G. Robinson, D. Santafianos, M.S. J. Simmonds, P.L. Toogood, Tetrahedron 1989, 45, 5175-5192.
166. Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles D.S. Brown, M. Bruno, R.J. Davenport, S.V. Ley, Tetrahedron 1989, 45, 4293-4308.
165. Microbial oxidation in synthesis: preparations of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene S.V. Ley, M. Parra-Alvarez, A.J. Redgrave, F. Sternfeld, Tetrahedron Lett. 1989, 30, 3557-3560.
164. Total synthesis of (+)-milbemycin b1 N.J. Anthony, A. Armstrong, S.V. Ley, A. Madin, Tetrahedron Lett. 1989, 30, 3209-3212.
163. Microbial oxidation in synthesis: preparation of (+)-and (–)-pinitol from benzene S.V. Ley and F. Sternfeld, Tetrahedron 1989, 45, 3463-3476.
162. Substitution reactions of 2-benzenesulphonyl cyclic ethers with silyl enol ethers promoted by aluminium trichloride D.S. Brown, S.V. Ley, M. Bruno, Heterocycles 1989, 28, (Special Issue No. 2), 773-777.
161. Chemistry of insect antifeedants from Azadirachta indica (Part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment S.V. Ley, A. Abad Somovilla, H.B. Broughton, D. Craig, A.M.Z. Slawin, P.L. Toogood, D.J. Williams, Tetrahedron 1989, 45, 2143-2164.
160. The antifeedant activity of clerodane diterpenes from teucrium M.J.S. Simmonds, W.M. Blaney, S.V. Ley, G. Savona, M. Bruno, B. Rodriguez. Phytochemistry 1989, 28, 1069-1071.
159. Recent developments in natural product synthesis S.V. Ley, Pure and Appl. Chem. 1989, 61, 401-404.
158. Preparation of O-methyl 3-acyl tetronic acids by direct acylation of stannyl tetronates S.V. Ley and D.J. Wadsworth, Tetrahedron Lett. 1989, 30, 1001-1004.
157. Activity of drimane antifeedants and related compounds against aphids and comparative biological effects and chemical reactivity of (–)- and (+)-polygodial Y. Asakawa, G.W. Dawson, D.C. Griffiths, J.-Y. Lallemand, S.V. Ley, K. Mori, A. Mudd, M. Pezechk-Leclaire, J.A. Pickett, H. Watanabe, C.M. Woodcock, Z. Zhong-Ning, J. Chem. Ecol. 1988, 14, 1845-1855.
156. Organic synthesis with tricarbonyliron lactone complexes S.V. Ley, Phil. Trans. R. Soc. Lond. 1988, 326, 633-640.
155. Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: total synthesis of the plasmodial pigment fuligorubin A S.V. Ley, S.C. Smith and P.R. Woodward, Tetrahedron Lett. 1988, 29, 5829-5832.
154. Chemistry of insect antifeedants from Azadirachta indica (part 3): reactions on the C-22,23 enol ether double bond of azadirachtin and conversion to the 22,23-dihydro-23b-methoxyazadirachtin J.C. Anderson, S. V. Ley, N.G. Robinson, W.M. Blaney, Z. Lidert, E.D. Morgan, M.S.J. Simmonds, Tetrahedron Lett. 1988, 29, 5433-5436.
153. Microbial oxidation in synthesis. Preparation from benzene of the cellular secondary messenger myo-inositol-1,4,5-trisphosphate (IP3) and related derivatives S.V. Ley and F. Sternfeld, Tetrahedron Lett. 1988, 29, 5305-5308.
152. Preparation of cyclic ether acetals from 2-benzenesulphonyl derivatives: a new mild glycosidation procedure D.S. Brown, S.V. Ley, S. Vile, Tetrahedron Lett. 1988, 29, 4873-4876.
151. Direct substitution of 2-benzenesulphonyl cyclic ethers using organozinc reagents D.S. Brown and S.V. Ley, Tetrahedron Lett. 1988, 29, 4869.
150. Insect antifeedants: a behavioural and electrophysiological investigation of natural and synthetically derived clerodane diterpenoids W.M. Blaney, M.S. H. Simmonds, S.V. Ley, P.S. Jones, Entomol. Exp. Appl. 1988, 29, 267-274.
149. Chemistry of insect antifeedants from azadirachta indica (part 2): synthesis of a polyoxygenated decalin with limonoid structural homology M.G. Brasca, H.B. Broughton, D. Craig, S.V. Ley, A. Abad Sommovilla, P.L. Toogood, Tetrahedron Lett. 1988, 29, 1853-1856.
148. Chemistry of insect antifeedants from azadirachta indica (part 1): conversion from the azadirachtin to the azadirachtin skeletons J.N. Bilton, P.S. Jones, S.V. Ley, N.G. Robinson, R.N. Sheppard, Tetrahedron Lett. 1988, 29, 1849-1852.
147. Preparation of tert-butyl acetothioacetate and use in the synthesis of 3-acetyl-4-hydroxy-5,5-dimethylfuran-2(5H)-one C.M.J. Fox and S.V. Ley, Org. Synth. 1987, 66, 108.
146. Natural pesticides from the neem tree (Azadirachta indica A. Juss) and other tropical plants Publ. Dt. Ges. Fur. Techn. Zusammenarbeit (GTZ) GmbH. Ed. H. Schmutherer. H.B. Broughton, P.S. Jones, S.V. Ley, E.D. Morgan, A.M.Z. Slawin, D.J. Williams, 1987, 103. ISBN 388085372X, 9783880853720
145. Development of a synthetic route towards milbemycin b1: preparation of an advanced model system N.J. Anthony, P. Grice, S.V. Ley, Tetrahedron Lett. 1987, 28, 5763-5766.
144. Synthesis of a novel 3,4-dihydromilbemycin analogue C. Greck, P. Grice, A.B. Jones, S.V. Ley, Tetrahedron Lett. 1987, 28, 5759-5762.
143. Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins N.J. Anthony, T. Clarke, A.B. Jones, S.V. Ley, Tetrahedron Lett. 1987, 28, 5755-5758.
142. A conformational study of bafilomycin A1 by x-ray crystallography and NMR techniques G.H. Baker, P.J. Brown, R.J.J. Dorgan, J.R. Everet, S.V. Ley, A.M.Z. Slawin, D.J. Williams, Tetrahedron Lett. 1987, 28, 5565-5568.
141. Preparation and use of tetra-n-butylammonium perruthenate (TBAP reagent) and tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols W.P. Griffiths, S.V. Ley, G.P. Whitecombe, A.D. White, J. Chem. Soc., Chem. Commun. 1987, 1625-1627.
140. Progress towards avermectins and milbemycins S.V. Ley, Pestic. Sci. 1987, 18, 153-154.
139. The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides S.V. Ley and P.R. Woodward, Tetrahedron Lett. 1987, 28, 3019-3020.
138. An x-ray crystallographic, mass spectroscopic and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives J.N. Bilton, H.B. Broughton, P.S. Jones, S.V. Ley, Z. Lidert, E.D. Morgan, H.S. Rzepa, R.N. Sheppard, A.M. Z. Slawin, D.J. Williams, Tetrahedron 1987, 43, 2805-2815.
137. An ectrophysiological and behavioural study of insect antifeedants properties of natural and synthetic drimane related compounds W.M. Blaney, M.S. J. Simmonds, S.V. Ley, R.B. Katz,Physiol. Entomol. 1987, 12, 281.
136. Synthesis of insect antifeedants in Pesticide Science and Biotechnology S.V. Ley. Ed R. Greenhalgh and T.R. Roberts, Blackwell, Oxford, 1987, 25. ISBN 0632016183 ISBN-13 : 978-0632016181
135. Seleninic anhydrides and acids in organic synthesis in Organoselenium Chemistry S.V. Ley. Ed. D. Liotta, J. Wiley, New York, 1987, 163.
134. Use of t-butylacetothioacetate in the preparation of milbemycin seco- analogues T. Clarke and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1987, 131-135.
133. Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic and carlic acids P.M. Booth, C.M.J. Fox, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1987, 121-129.
132. Preparation of t-butyl-4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides S.V. Ley and P.R. Woodward, Tetrahedron Lett. 1987, 28, 345-346.
131. Microbial oxidation in synthesis: a six step preparation of (+)-pinitol from benzene S.V. Ley, S. Taylor, F. Sternfeld, Tetrahedron Lett. 1987, 28, 225-226.
130. Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: a potent insect antifeedant S.V. Ley, D. Santafianos, W.M. Blaney, M.S.J. Simmonds, Tetrahedron Lett. 1987, 28, 221-224.
129. Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes P.S. Jones, S.V. Ley, N.S. Simpkins, A.J. Whittle, Tetrahedron 1986, 42, 6519-6534.
128. Preparation of spiroketals by reaction of anions from 2-benzenesulphonyl-tetrahydropyrans with epoxides: synthesis of the C-11 to C-25 fragment of the milbemycins C. Greck, P. Grice, S.V. Ley, A. Wonnacott, Tetrahedron Lett. 1986, 27, 5277-5280.
127. Ultrasonic formation and reactions of sodium phenylselenide, S.V. Ley, I.A. O’Neil, C.M.R. Low, Tetrahedron 1986, 42, 5363-5368.
126. Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal synthesis S.V. Ley, B. Lygo, F. Sternfeld, A. Wonnacott, Tetrahedron 1986, 42, 4333-4342.
125. Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2′-trimethylsilylethoxymethyl) pyrrole and 1-(2′-trimethylsilylethoxymethyl)indole M.P. Edwards, A.M. Doherty, S.V. Ley, H.M. Organ, Tetrahedron 1986, 42, 3723-3729.
124. Synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction G. Brussani, S.V. Ley, J.L. Wright, D.J.Williams, J. Chem. Soc., Perkin Trans. 1 1986, 303-307.
123. Application of ultrasound to the preparation of tricarbonyliron diene complexes S.V. Ley, C.M.R. Low, A.D. White, J. Organometallic Chem. 1986, C13-C16.
122. Synthetic approaches to the teleocidin-related tumour promoters: a total synthesis of indolactam V S.E. de Laszlo, S.V. Ley and R.A. Porter, J. Chem. Soc., Chem. Commun. 1986, 344-346.
121. X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin H.B. Broughton, S.V. Ley, E.D. Morgan, A.M.Z. Slawin, D.J. Williams, J. Chem. Soc., Chem. Commun. 1986, 46-47.
120. Synthetic studies towards the acyltetronic acid ionophore M139603 A.M. Doherty and S.V. Ley, Tetrahedron Lett. 1986, 27, 105-108.
119. The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides C.M.J. Fox, S.V. Ley, A.M.Z. Slawin, D.J. Williams, J. Chem. Soc., Chem. Commun. 1985, 1805-1806.
118. Synthesis of the β-lactam antibiotic (+)-thienamycin via an intermediate π-allyltricarbonyliron lactone complex S.T. Hodgson, D.M. Hollinshead, S.V. Ley, Tetrahedron 1985, 41, 5871-5878.
117. Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[(p-benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one S.T. Hodgson, D.M. Hollinshead, S.V. Ley, C.M.R. Low, D.J. Williams. J. Chem. Soc., Perkin Trans. 1 1985, 2375-2381.
116. Total synthesis of the sesquiterpene hirsutene using an organoselenium-mediated cyclisation reaction S.V. Ley, P.J. Murray, B.D. Palmer, Tetrahedron 1985, 41, 4765-4769.
115. Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C-15 to C-16 bond D. Culshaw, P. Grice, S.V. Ley, G.A. Strange, Tetrahedron Lett. 1985, 26, 5837-5840.
114. Structural reappraisal of the limonoid insect antifeedant azadirachtin J.N. Bilton, H.B. Broughton, S.V. Ley, Z. Lidert, E.D. Morgan, H.S. Rzepa, R.N. Sheppard, J. Chem. Soc., Chem. Commun. 1985, 968-971.
113. Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone D. Craig, S.V. Ley, N.S. Simpkins, G.H. Whitham, M.J. Prior, J. Chem. Soc., Perkin Trans. 1 1985, 1949-1952.
112. Wittig and Horner-Wittig coupling reactions of 2-substituted cyclic ethers and their application to spiroketal synthesis S.V. Ley, B. Lygo, H.M. Organ, A. Wonnacott, Tetrahedron 1985, 41, 3825-3836.
111. Synthesis of some insect antifeedants S.V. Ley, Society of Chemical Industry/Royal Society of Chemistry Symposium Special Publication No. 53, 1985, 307.
110. Organometallics in synthesis, part I, the transition elements D.M. Hollinshead and S.V. Ley, Royal Society of Chemistry, Specialist Periodical Reports, Gen. Synth. Meth. 1985, 7, 233.
109. Natural product synthesis using π-allyltricarbonyliron lactone complexes: synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide A.M. Horton and S.V. Ley, J. Organometallic Chem. 1985, 285, C17-C20.
108. Synthetic applications of ynes, enes and ones; organoselenium-mediated cyclisation reactions in organic synthesis S.V. Ley, Chem. and Ind. 1985, 101-106.
107. Preparation and reactions of 2-benzenesulphonyltetrahydropyran S.V. Ley, B. Lygo, A. Wonnacott, Tetrahedron Lett. 1985, 26, 535-538.
106. Total synthesis of the ionophore antibiotic X-14547A (indanomycin) M.P. Edwards, S.V. Ley, S.G. Lister, B.D. Palmer, D.J. Williams, J. Org. Chem. 1984, 49, 3503-3516.
105. Natural product synthesis via π-allyltricarbonyliron lactone complexes G.D. Annis, E.M. Hebblethwaite, S.T. Hodgson, A.M. Horton, D. M. Hollinshead, S.V. Ley, C.R. Self, R. Sivaramakrishnan, 2nd SCI/RSC Medicinal Chemistry Symposium. Special Publication, No. 50, 1984, 148-161.
104. Synthesis of (+/-)cis-6-methyltetrahydropyran-2-yl acetic acid a natural product from Viverra civetta using organoselenium-mediated cyclisation reactions S.V. Ley, B. Lygo, H. Molines, J. Chem. Soc., Perkin Trans. 1, 1984, 2403-2405.
103. Synthesis of the spiroacetal unit related to the avermectins and milbemycins J. Godoy, S.V. Ley, B. Lygo, J. Chem. Soc., Chem. Commun. 1984, 1381-1382.
102. The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives P.C. Bulman-Page and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1984, 1847-1858.
101. Novel rearrangement of the ionophore antibiotic X-14547 (indanomycin) and related derivatives induced by lithium tetrafluoroborate M.P. Edwards and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1984, 1761-1763.
100. Fe2(CO)9 in tetrahydrofuran or under sonochemical conditions as convenient routes to π-allyltricarbonyliron lactone complexes A.M. Horton, D.M. Hollinshead, S.V. Ley, Tetrahedron 1984, 40, 1737-1742.
99. Synthesis of spiroacetals using organoselenium mediated cyclisation reactions, x-ray molecular structure of (2S, 8R)-8-methyl-2-phenyl-1,7-dioxaspiro-[5.5]undecan-4(R)-ol A.M. Doherty, S.V. Ley, B. Lygo, D.J. Williams, J. Chem. Soc., Perkin Trans. 1 1984, 1371-1377.
98. π-Allyltricarbonyliron lactone complexes in synthesis: application to the synthesis of the β-lactam antibiotic (+)-thienamycin S.T. Hodgson, D.M. Hollinshead, S.V. Ley, J. Chem. Soc., Chem. Commun. 1984, 494-496.
97. Oxo complexes of ruthenium (VI) and (VII) as organic oxidants G. Green, W.P. Griffith, D.M. Hollinshead, S.V. Ley, M. Schrader, J. Chem. Soc., Perkin Trans. 1 1984, 681.
96. A new route to spiroketals using the Horner-Wittig reaction of 2- diphenylphosphinoxy cyclic ethers S.V. Ley and B. Lygo, Tetrahedron Lett. 1984, 25, 113-116.
95. Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones S.V. Ley and N.S. Simpkins, J. Chem. Soc., Chem. Commun. 1983, 1281-1282.
94. Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyltetronic acids P.M. Booth, C.M.J. Fox, S.V. Ley, Tetrahedron Lett. 1983, 24, 5143-5146.
93. Synthesis of β-lactams from π-allyltricarbonyliron lactone complexes G.D. Annis, E.M. Hebblethwaite, S.T. Hodgson, D.M. Hollinshead, S.V.Ley, J. Chem. Soc., Perkin Trans. 1 1983, 2851-2856.
92. Stereochemistry of a 5,5,10-trimethyldecan-2-one by 1H-NMR: A new application of INDOR difference spectroscopy S.V. Ley, A.J. Whittle, G.E. Hawkes, J. Chem. Res. 1983, 210-211.
91. The Diels-Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin, and warburganal D.M. Hollinshead, S.C. Howell, S.V. Ley, M. Mahon, N.M. Ratcliffe, P.A. Worthington, J. Chem. Soc., Perkin Trans. 1 1983, 1579-1589.
90. Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin and valdiviolide S.V. Ley and M. Mahon, J. Chem. Soc. Perkin Trans. 1 1983, 1379-1381.
89. Organometallics in synthesis. Part I. The transition elements S.V. Ley and R.A. Porter, Specialist Periodical Reports, Gen. Synth. Meth. 1983, 6, 218.
88. Total synthesis of the structurally unique ionophore antibiotic, X-14547A M.P. Edwards, S.V. Ley, S.G. Lister, B.D. Palmer, J. Chem. Soc., Chem. Commun. 1983, 630-633.
87. The total synthesis of the clerodane diterpene insect antifeedant, ajugarin I S.V. Ley, N.S. Simpkins, A.J. Whittle, J. Chem. Soc., Chem. Commun. 1983, 503-505.
86. An unexpected rearrangement reaction of 4-alkylaminoindoles S.V. Ley and R.A. Porter, J. Chem. Soc., Chem. Commun. 1982, 1356-1357.
85. A short synthesis of (+/-)-hirsutene involving the use of an organoselenium mediated cyclization reaction S.V. Ley and P. J. Murray, J. Chem. Soc., Chem. Commun. 1982, 1252-1253.
84. Synthesis of (cis-6-methyltetrahydropyran-2-yl) acetic acid involving the use of an organoselenium mediated cyclization reaction S.V. Ley, B. Lygo, H. Molines, J.A. Morton, J. Chem. Soc., Chem. Commun. 1982, 1251-1252.
83. Synthesis of methyl-1,6-dioxaspiro[4,5]decanes using organoselenium mediated cyclisation reactions S.V. Ley and B. Lygo, Tetrahedron Lett. 1982, 23, 4625-4628.
82. Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions D.H.R. Barton, R.A.H.F. Hui, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1982, 2179-2185.
81. Synthesis of polyoxygenated trans-decalins as potential insect antifeedants S.V. Ley, D. Neuhaus, N.S. Simpkins, A.J. Whittle, J. Chem. Soc., Perkin Trans. 1 1982, 2157-2162.
80. A practical catalytic method for the preparation of steroidal 1,4-diene-3-ones by oxygen transfer from iodoxybenzene to diphenyl diselenide D.H.R. Barton, C.R.A. Godfrey, J.W. Morzycki, W.B. Motherwell, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1982, 1947-1952.
79. Dehydrogenation of lactones using benzeneseleninic anhydride: x-ray crystal structure of 3β-acetoxy-14α-hydroxy-17a-oxa-D-homo-5α-androst-15-en-17-one D.H.R. Barton, R.A.H.F. Hui, S.V. Ley, D.J. Williams, J. Chem. Soc., Perkin Trans 1 1982, 1919-1922.
78. Thermal rearrangement reactions of tricarbonyliron lactone complexes G.D. Annis, S.V. Ley, C.R. Self, R. Sivaramakrishnan, D.J. Williams, J. Chem. Soc., Perkin Trans. 1 1982, 1355-1361.
77. The x-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum J.R. Hanson, D.E.A. Rivett, S.V. Ley, D. J. Williams, J. Chem. Soc., Perkin Trans. 1 1982, 1005-1008.
76. A conformational study of elaiophylin by x-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect S.V. Ley, D. Neuhaus, D.J. Williams, Tetrahedron Lett. 1982, 1207-1210.
75. Organometallics in synthesis part I. The transition elements S.V. Ley and R.A. Porter, Specialist Periodical Reports, Gen. Synth. Meth. 1982, 5, 208.
74. Annual reports of the Royal Society of Chemistry part B. Organosulphur, organoselenium and organotellurium chemistry S.V. Ley, 1980, 77, 233-261.
73. Oxygen atom transfer from iodlybenzene to diphenyl diselenide: a convenient catalytic method for dehydrogenation of steroidal 3-ketones D.H.R. Barton, J. Morzycki, W.B. Motherwell, S.V. Ley, J. Chem. Soc., Chem. Commun. 1981, 1044-1045.
72. Synthesis of euryfuran, valdiviolide and confertifolin S.V. Ley and M. Mahon, Tetrahedron Lett.1981, 22, 4747-4750.
71. Synthesis of a trans-decalin as a potential insect antifeedant S.V. Ley, N.S. Simpkins, A.J. Whittle, J. Chem. Soc., Chem. Commun. 1981, 1001-1003.
70. Synthesis of (+/-)-warburganal S.V. Ley and M. Mahon, Tetrahedron Lett. 1981, 22, 3909-3912.
69. A convenient preparation of 2-haloenones from enones using phenylselenium halides S.V. Ley and A.J. Whittle, Tetrahedron Lett. 1981, 3301-3304.
68. Experiments on the synthesis of tetracycline. Part 16 improved photocyclic preparation of 12-keto derivatives and their deprotection using benzeneseleninic anhydride D.H.R. Barton, M.T. Bielska, J.M. Cardoso, N.J. Cussans, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1981, 1840-1845.
67. Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration W.P. Jackson, S.V. Ley, J.A. Morton, Tetrahedron Lett. 1981, 22, 2601-2604.
66. Synthesis of cinnamolide and polygodial S.C. Howell, S.V. Ley, M. Mahon, P.A. Worthington, J. Chem. Soc., Chem. Commun. 1981, 507-508.
65. Diaryl telluroxides as new mild oxidising reagents S.V. Ley, C.A. Meerholz, D.H.R. Barton, Tetrahedron 1981, 37, 213-223.
64. The synthesis and Diels-Alder reactions of 2-prop-2-enylidene-1,3-dioxolan S.V. Ley, W. L. Mitchell, T.V. Radhakrishnan, D.H.R. Barton, J. Chem. Soc., Perkin Trans. 1 1981, 1582-1584.
63. Synthesis of substituted cis-decalins as potential insect antifeedants W.P. Jackson and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1981, 1516-1519.
62. Oxidation of phenols, pyrocatechols, and hydroquinones to ortho-quinones using benzeneseleninic anhydride D.H.R. Barton, A.G. Brewster, S.V. Ley, C.M. Read, M.N. Rosenfeld, J. Chem. Soc., Perkin Trans. 1 1981, 1473-1476.
61. On the reaction of thioacetals with sulphuryl chloride P.C. Bulman-Page, S.V. Ley, J.A. Morton, D.J. Williams, J. Chem. Soc., Perkin Trans. 1 1981, 457-461.
60. Preparation of lactones via tricarbonyliron lactone complexes G.D. Annis, S.V. Ley, C.R. Self, R. Sivaramakrishnan, J. Chem. Soc., Perkin Trans. 1 1981, 270-277.
59. An intramolecular Diels-Alder approach to the synthesis of the right hand half of the ionophoric antibiotic X-14547 A M.P. Edwards, S.V. Ley, S.G. Lister, Tetrahedron Lett. 1981, 361-364.
58. Selenium mediated cyclisation reactions of alkenyl substituted β-ketoesters W.P. Jackson, S.V. Ley, A.J. Whittle, J. Chem. Soc., Chem. Commun. 1980, 1173-1174.
57. New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N-phenylselenophthalimide W.P. Jackson, S.V. Ley, J.A. Morton, J. Chem. Soc. Chem. Commun. 1980, 1028-1029.
56. Dehydrogenation of steroidal and triterpenoid ketones using benzeneseleninic anhydride D.H.R. Barton, D.J. Lester, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1980, 2209-2212.
55. Catalytic oxidation of thiocarbonyl compounds involving the use of 1,2-dibromotetrachloroethane as a brominating reagent for diaryl Te(II) species S.V. Ley, C.A. Meerholz, D.H.R. Barton, Tetrahedron Lett. 1980, 1785-1788.
54. Removal of thioacetal protecting groups by benzeneselenininc anhydride D.H.R. Barton, N.J. Cussans, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1980, 1654-1657.
53. Conversion of thiocarbonyl compounds into their corresponding oxo derivatives using benzeneseleninic anhydride D.H.R. Barton, D.J. Lester, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1980, 1650-1653.
52. Oxidation of ketone and aldehyde hydrazones, oximes and semi- carbazones and of hydroxylamines and hydrazo compounds using benzeneseleninic anhydride D.H.R. Barton, D.J. Lester, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1980, 1212-1217.
51. A new synthetic approach towards adriamycin D.H.R. Barton, C.C. Dawes, G. Franceschi, M. Foglio, S.V. Ley, P.D. Magnus, W.L. Mitchell, A. Temperelli, J. Chem. Soc., Perkin Trans. 1 1980, 643-647.
50. Thermal decomposition of tricarbonyliron lactone complexes G.D. Annis, S.V. Ley, C.R. Self, R. Sivaramakrishnan, J. Chem. Soc., Chem. Commun. 1980, 299-299.
49. Formation of β-lactams from tricarbonyliron lactones complexes G.D. Annis, E.M. Hebblethwaite, S.V. Ley, J. Chem. Soc., Chem. Commun. 1980, 297-298.
48. Sulphuration of electron-rich arenes with sulphenamides and aminosulphenyl chlorides M.U. Bombala and S.V. Ley, Syn. Commun. 1980, 10, 291-297.
47. Isolation characterisation and oxidation of isomeric ferralactone complexes G.D. Annis, S.V. Ley, R. Sivaramakrishnan, A.M. Atkinson, D. Rogers, D.J. Williams, J. Organometallic Chem. 1979, 182, C11-C14.
46. Preparation of episulphides from alkenes via succinimide-N-sulphenyl chloride or phthalimide-N-sulphenyl chloride adducts M.U. Bombala and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1979, 3012-3016.
45. Bis(p-methoxyphenyl) telluroxide: a new mild oxidising agent D.H.R. Barton, S.V. Ley, C.A. Meerholz, J. Chem. Soc., Chem. Commun. 1979, 755-756.
44. Synthesis of a substituted cis-decalin as a potential insect antifeedant W.P. Jackson, S.V. Ley, J. Chem. Soc., Chem. Commun. 1979, 732-733.
43. Preparation of aldehydes and ketones by oxidation of benzylic hydrocarbons with benzeneselenininic anhydride D.H.R. Barton, R.A.H.F. Hui, D.J. Lester, S.V. Ley, Tetrahedron Lett. 1979, 20, 3331-3334.
42. The crystal structure of 3-epicaryoptin and the reversal of the currently accepted absolute configuration of clerodin D. Rogers, G.G. Unal, D.J. Williams, S.V. Ley, G.A. Sim, B.S. Joshi, K.R. Ravindranath, J. Chem. Soc., Chem. Commun. 1979, 97-99.
41. Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10pi homoaromatic dianions L.A. Paquette. G.D. Ewing, S.V. Ley, H.C. Berk, S.G. Traynor, J. Org. Chem. 1979, 43, 4712-4720.
40. Oxidation of alcohols using benzeneseleninic anhydride D.H.R. Barton, A.G. Brewster, R.A.H.F. Hui, D.J. Lester, S.V. Ley, T.G. Back, J. Chem. Soc., Chem. Commun. 1978, 952-954.
39. The formation of unusual sultones during the rearrangement reactions of bicyclic ketones D.S. Brown, H. Heaney, S.V. Ley, K.G. Mason, P. Singh, Tetrahedron Lett. 1978, 41, 3937-3940.
38. Thermal isomerization of homoazocines G.D. Ewing, S.V. Ley, L.A. Paquette, J. Am. Chem. Soc. 1978, 100, 2909-2911.
37. Conversion of thiocarbonyl compounds into their corresponding oxo derivatives using benzeneseleninic anhydride D.H. R. Barton, N.J. Cussans, S.V. Ley, J. Chem. Soc., Chem. Commun. 1978, 393-394.
36. Oxidation of aldehyde hydrazones, hydrazo compounds and hydroxylamines with benzeneseleninic anhydride D.H.R. Barton D.J. Lester, S.V. Ley, J. Chem. Soc. Chem. Commun. 1978, 276-277.
35. Dehydrogenation of steroidal ketones using benzeneseleninic anhydride D.H.R. Barton, D.H. Lester, S.V. Ley, J. Chem. Soc. Chem. Commun. 1978, 130-131.
34. Design of a specific oxidant for phenols D.H.R. Barton and S.V. Ley, Further Perspectives in Organic Chemistry, Ciba Foundation Symposium, 1978, 53-66.
33. Reaction of tetracycline hydrochloride with N-chlorosuccinimide: X-ray crystal structure of the major product D.H.R. Barton, S.V. Ley, K. Meguro, D.J. Williams J. Chem. Soc., Chem. Commun. 1977, 790-791.
32. Removal of 1,3-dithiolan protecting groups by benzeneseleninic anhydride D.H.R. Barton, N.J. Cussans, S.V. Ley, J. Chem. Soc. Chem. Commun. 1977, 751-752.
31. Formation of lactones from dienes via iron carbonyl complexes G.D. Annis, S.V. Ley, J. Chem. Soc. Chem. Commun. 1977, 581-582.
30. The question of delocalization in “anchored” ions with potential trishomoaromatic character: reduction of tricyclo[5.4.1.04,12]dodeca- 2,5,8,10-tetraene as a route to the 10.pi.11C dianion L.A. Paquette, M.J. Kukla, S.V. Ley, S.G. Traynor, J. Am. Chem. Soc. 1977, 99, 4756-4763.
29. Regeneration of the carbonyl functionality from hydrazones, oximes and semicarbazones by benzeneseleninic anhydride D.H.R. Barton, D. J. Lester, S.V. Ley, J. Chem. Soc., Chem. Commun. 1977, 445-446.
28. X-ray evidence for partial bonding between sulphur or selenium and oxygen in thio- and seleno-imines A. Atkinson, A.G. Brewster, S.V. Ley, R.S. Osborn, D. Rogers, D.J. Williams, K.A. Woode, J. Chem. Soc., Chem. Commun. 1977, 325-326.
27. The mechanism of the thermal decomposition of tetra-aryl tellurium species D.H.R. Barton, S.A. Glover, S.V. Ley, J. Chem. Soc., Chem. Commun. 1977, 266-267.
26. Preparation of phenylselenoimines from phenols using diphenylseleninic anhydride and hexamethyldisilazane D.H.R. Barton, A.G. Brewster, S.V. Ley, M.N. Rosenfeld, J. Chem. Soc., Chem. Commun. 1977, 147-148.
25. Experiments on the synthesis of tetracycline part 15. Oxidation of phenols and ring A. Model phenols to O-hydroxydienones with benzeneseleninic anhydride D.H.R. Barton, S.V. Ley, P.D. Magnus, M.N. Rosenfeld, J. Chem. Soc., Perkin Trans. 1 1977, 567-572.
24. Oxidation of phenols to ortho-quniones using diphenylseleninic anhydride D.H.R. Barton, A.G. Brewster, S.V. Ley, M.N. Rosenfeld, J. Chem. Soc., Chem. Commun. 1976, 985-986.
23. Formation of monohomocyclootatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation L.A. Paquette, S.V. Ley, S.G. Traynor, J.T. Martin, J.M. Geckle, J. Am. Chem. Soc. 1976, 98, 8162-8172.
22. Homotropylium-8-sulfinate complexes by SbF5 promoted ring opening of 9-thiabicyclo-[4.2.1]nona-2,4,7-triene and 9-thiabarbaralane 9,9-dioxides L.A. Paquette, U. Jacobson, S.V. Ley, J. Am. Chem. Soc. 1976, 98, 152-158.
21. Synthesis, chiroptical properties and absolute configuration of (+)-2,3- dihydrotriquinacen-3-one. Effect of rigid triquinacene geometry on the inherently dissymmetric chromophore L.A. Paquette, W.B. Farnham, S.V. Ley, J. Am. Chem. Soc. 1975, 97, 7273-7379.
20. The stability of N,N-dialkylthiohydroxylamines D.H.R. Barton, S.V. Ley, P.D. Magnus, J. Chem. Soc., Chem. Commun. 1975, 855-856.
19. Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts L.A. Paquette, S.V. Ley, S. Maiorana, D.F. Schneider, M.J. Broadhurst, R.A. Boggs, J. Am. Chem. Soc. 1975, 97, 4658-4667.
18. Unsaturated heterocyclic systems. XCII. Nitrogen analogs of 1,6-methano[12]annulene. Effect on valence tautomerism of the locus of aza substitution L.A. Paquette, H.C. Berk, S.V. Ley, J. Org. Chem. 1975, 40, 902-909.
17. Rearrangement reactions of bicyclic systems. Part IV. Acid catalysed rearrangements of 5,6,7,8-tetrafluoro-1,4-dihydro-1-methoxy-3,9-dimethyl- 1,4-ethenonaphthalene (1-methoxy-3,5-dimethyltetrafluorobenzobarrelene) H. Heaney and S.V. Ley, J. Chem.Soc., Perkin Trans. 1 1974, 2711-2715.
16. Rearrangement reactions of bicyclic systems. Part III. Acid-catalysed rearrangements of 1,4-dihydro-1-methoxy-1,4-ethenonaphthalene (1- methoxybenzobarrelene) and its 5,6,7,8-tetrahalogeno-derivatives N.H. Hales, H. Heaney, S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1974, 2702-2711.
15. Rearrangement reactions of bicyclic systems. Part II. Rearrangements of 1- dimethylamino-5,6,7,8-tetrahalogeno-1,4-dihydro-1,4-ethenonaphthalene derivatives and the analogous 5,6,7,8-tetrafluoro-1,4-dihydro-N-methyl-1,4- iminonaphthalene in aqueous solutions H. Heaney and S.V.Ley, J. Chem. Soc., Perkin Trans. 1, 1974, 2698-2701.
14. Aryne chemistry. Part XXXV. Reactions of arynes with 1-amino- cycloalkenes and hydrolyses of the adducts H. Heaney and S.V. Ley, J. Chem. Soc., Perkin Trans. 1 1974, 2693-2694.
13. Aryne chemistry. Part XXXIV. Reactions of N,N-dimethylarylamines with tetra-halogenobenzynes J.P.N. Brewer, H. Heaney, S.V. Ley, T.J. Ward, J. Chem. Soc., Perkin Trans. 1 1974, 2688-2693.
12. Aryne chemistry. Part XXXIII. Reactions of tetrahalogenobenzynes with methoxyarenes and the photolysis and themolysis of some of the products P.C. Buxton, N.J. Hales, B. Hankinson, H. Heaney, S.V. Ley, R.P. Sharma, J. Chem. Soc., Perkin Trans. 1 1974, 2681-2687.
11. Preparation of 1-benzylindole H. Heaney and S.V. Ley, Org. Synth. 1974, 54, 58-59. DOI: 10.15227/orgsyn.054.0058
10. Alkali metal reduction studies of cis– and trans-bicyclo[6.1.0.]nona-2,4,6- trienes in liquid ammonia. Evidence for the high basicity of monohomocyclooctatetraene dianions S.V. Ley and L.A. Paquette, J. Am. Chem. Soc. 1974, 96, 6670-6679. https://doi.org/10.1021/ja00828a021
9. Directed synthesis of the isomeric dimethylcyclooctatetraenes and a study of their polarographic and alkali metal reduction L.A. Paquette, S.V. Ley, R.H. Meisinger, R.K. Russell, M. Oku, J. Am. Chem. Soc. 1974, 96, 5806–5815. https://doi.org/10.1021/ja00825a019
8. An efficient synthesis of (–)-triquinacene-2-carboxylic acid L.A. Paquette, S.V. Ley, W.B. Farnham, J. Am. Chem. Soc. 1974, 96, 312-313.
7. Mechanistic dichotomy in cycloadditions to cyclooctatetraeneiron tricarbonyl. X-ray crystal structure analysis of the TCNE and CSI adducts L.A. Paquette, S.V. Ley, M.J. Broadhurst, D. Truesdell, J. Fayos, J. Clardy, Tetrahedron Lett. 1973, 2943–2946.
6. Rearrangement reactions of bicyclic systems. Part I. Synthesis of a model compound related to flavothebaone trimethyl ether. The abnormal ultraviolet absorption spectrum of flavothebaone and its trimethyl ether H. Heaney, J.H. Hollinshead, G.W. Kirby, S.V. Ley, R.P. Sharma, K.W. Bentley, J. Chem. Soc., Perkin Trans. I, 1973, 1840-1843.
5. Thermal reactions of 1,4-bridged-1,2,3,4-tetrahydronaphthalene derivatives H. Heaney, S.V. Ley, A.P. Price, R.P. Sharma, Tetrahedron Lett. 1972, 3067–3070.
4. N-Alkylation of indole and pyrroles in dimethyl sulphoxide H. Heaney and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 1973, 499-500.
3. Acid catalysed rearrangements of 3,5-dimethyl-1-methoxytetrafluorobenzobarrelene (5,6,7,8-tetrafluoro-1,4-dihydro-3,10-dimethyl-1-methoxy-1,4-ethenonaphthalene) H. Heaney and S.V. Ley, J. Chem. Soc. D, Chem. Commun. 1971, 1342-1343.
2. Multiple rearrangement reactions of 1-methoxybenzobarrelene(1,4-dihydro-1-methoxy-1,4-ethenonaphthalene) derivatives H. Heaney and S.V. Ley, J. Chem. Soc. D, Chem. Commun. 1971, 224-225.
1. Rearrangement reaction of 1-N,N-dimethylaminobenzobarrelene derivatives H. Heaney and S.V. Ley, J. Chem. Soc. D, Chem. Commun. 1970, 1184.
