Please find here a list of all our publications, divided up by decade:
2010-Present
911. Straightforward, scalable, solution-phase synthesis of peptide bonds in flow Z.E. Wilson, E. Lopez, N.J. Flodén, C. Watkins, G. Bianchini, S.V. Ley Journal of Flow Chemistry, 2025, 1. (https://doi.org/10.1007/s41981-025-00347-2).
910. Carbonylative transformations with Pd catalysts supported on bio-degradable urea-based polymer – Part A M. Markovič, P. Lopatka, P. Koóš, T. Soták, A. Ház, T. Gracza, S.V. Ley, M. Králik Catal.Today, 2024, 441, 114903. (https://doi.org/10.1016/j.cattod.2024.114903).
909. Palladium catalysts supported on biodegradable urea-based polymers in synthesis with CO – Part B M. Markovič, P. Lopatka, P. Koóš, T. Soták, A. Ház, T. Gracza, S.V. Ley, M. Králik Catal.Today, 2024, 440, 114831. (https://doi.org/10.1016/j.cattod.2024.114831).
908. Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue S.C Schäfer, A.M. Voll, A. Bracher, S.V. Ley and F. Hausch Bioorg. Med. Chem. Lett., 2024, 104, 129728. (https://doi.org/10.1016/j.bmcl.2024.129728)
907. Continuous flow synthesis enabling reaction discovery
906. Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides S.E. Gatarz, O.M. Griffiths, H.A. Esteves, W.Jiao, P.Morse, E.L. Fisher, D.C. Blakemore and S.V. Ley J. Org. Chem. 2024, 89, 1898-1909. (https://doi.org/10.1021/acs.joc.3c02557).
905. Photoredox-Catalyzed Preparation of Sulfones Using Bis-Piperidine Sulfur Dioxide – An Underutilized Reagent for SO2Transfer O.M. Griffiths, H.A. Esteves, D.C. Emmet and S.V. Ley Chem. Eur.J.,2024, 30, e202303976 (6 pages). (https://doi.org/10.1002/chem.202303976)
904. Automated multistep synthesis of 2-pyrazolines in continuous flow R. Labes, J. C. Pastre, R. J. Ingham, C. Battilocchio, H. M. Marçon, M. C. F. C. B. Damião, D. N. Tran and S. V. Ley React. Chem. Eng.,2024, 9, 558-565. (https://doi.org/10.1039/D3RE00515A).
903. The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation S. L. Bourne, F. Amann, S. V. Ley, Chimia 2023, 77, 288-293. (https://doi.org/10.2533/chimia.2023.288).
902. Exploring the chemical space of phenyl sulfide oxidation by automated optimization
901. Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis O. M. Griffiths and S. V. Ley, J. Org. Chem. 2022, 87, 13204−13223.(https://doi.org/10.1021/acs.joc.2c01684).
900. Automated Multi-Objective Reaction Optimisation: Which Algorithm Should I Use? P. Müller, A. D. Clayton, J. Manson, S. Riley, O. S. May, N. Govan, S. Notman, S. V. Ley, T. W. Chamberlain and R. A. Bourne, Reac. Chem. Eng. 2022, 7, 987-993. (https://doi.org/10.1039/d1re00549a)
899. Outlook, Future Directions, and Future Applications S.V. Ley. O.S. May, O.M. Griffiths and K. Sowa in Flow Chemistry, 2nd Edition, Volume 2 – Applications edited by F. Darvas, G. Dormán, V. Hessel and S.V. Ley, Berlin, Boston: De Gruyter, 2021, pp. 313-345. ISBN 978-3-11-069361-4
898. Flow Chemistry – Fundamentals and Applications (Vol1&2 2nd Edition) edited by F. Darvas, G. Dormán, V. Hessel and S.V. Ley, Berlin, Boston: De Gruyter, 2021. Fundamentals and Applications (available as a set) Set-ISBN 978-3-11-073679-3. https://doi.org/10.1515/9783110693676
897. Process Intensification: From Green Chemistry to Continuous Processing, C. Battilocchio, S.V. Ley and E. Godineau in Sustainable Organic Synthesis: Tools and Strategies S. Protti and A. Palmieri (Eds.). RSC, 2021, 522-548 (Ch. 19). Print ISBN978-1-83916-203-9; ePub eISBN978-1-83916-485-9.
896. Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow O.M. Griffiths, H.A. Esteves, Y. Chen, K. Sowa, O.S. May, P. Morse, D.C. Blakemore, and S.V. Ley J. Org. Chem. 2021, 86, 13559-13571. (https://doi.org/10.1021/acs.joc.1c01621).
895. Enzymatic pretreatment of recycled grease trap waste in batch and continuous-flow reactors for biodiesel production, N.N. Tran, M. Escribà Gelonch, S. Liang, Z. Xiao, M. Mohsen Sarafraz, M. Tišma, H-J. Federsel, S.V. Ley, V. Hessel, Chemical Engineering Journal, 2021, 426, 131703. (https://doi.org/10.1016/j.cej.2021.131703).
894. Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions, H.R. Smallman, J.A. Leitch, T. McBride, S.V. Ley, D.L. Browne, Tetrahedron 2021, 93, 132305. (https://doi.org/10.1016/j.tet.2021.132305)
893. CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells, S. Roy, J. Sipthorp, B. Mahata, J. Pramanik, M. L. Hennrich, A-C. Gavin, S. V. Ley, S. A. Teichmann, iScience2021, 24, 102485. (https://doi.org/10.1016/j.isci.2021.102485)
892. A Comment on Continuous Flow Technologies within the Agrochemical Industry, S. V. Ley, Y. Chen, A. Robinson, B. Otter, E. Godineau, and C. Battilocchio, Org. Process Res. Dev. 2021, 25, 713–720. (https://doi.org/10.1021/acs.oprd.0c00534)
891. The Callipeltoside Story in Marine Natural Products: Topics in Heterocyclic Chemistry H. Kiyota (eds). Springer, Singapore 2020, 58, 467-517. Print ISBN 978-981-16-4636-2; Online ISBN978-981-16-4637-9.
890. Living with our machines: Towards a more sustainable future S. V. Ley, Y. Chen, D. E. Fitzpatrick and O. S. May Current Opinion in Green and Sustainable Chemistry 2020, 25, 100353. (https://doi.org/10.1016/j.cogsc.2020.100353)
889. Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin J. C. Pastre, P. R. D. Murray, D. L. Browne, G. A. Brancaglion, R. S. Galaverna, R. A. Pilli, S. V. Ley, ACS Omega 2020, 5, 18472–18483. (http://doi.org/10.1021/acsomega.0c02390)
888. Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins Y. Chen, N. McNamara, O. May, T. Pillaiyar, D. C. Blakemore, and S. V. Ley, Org. Lett. 2020, 22, 5746–5748. (https://doi.org/10.1021/acs.orglett.0c01730)
887. In silico rationalisation of selectivity and reactivity in Pd-catalysed C–H activation reactions L. Cao, M. Kabeshov, S. V. Ley, and A. A. Lapkin, Beilstein J. Org. Chem. 2020, 16, 1465–1475. (https://doi.org/10.3762/bjoc.16.122)
886. A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions D.E. Fitzpatrick, M. O’Brien, and S.V. Ley, React. Chem. Eng., 2020, 5, 201-220. (https://doi.org/10.1039/C9RE00407F)
885. A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters E. Watanabe, Y. Chen, O. May, and S. V. Ley, Chem. Eur. J. 2020, 26, 186-191. (https://doi.org/10.1002/chem.201905048)
884. Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source P. Lopatka, M. Markovic, P. Kooś, S. V. Ley and T. Gracza, J. Org. Chem. 2019, 84, 14394−14406. (https://doi.org/10.1021/acs.joc.9b02453)
883. A New World for Chemical Synthesis? S. V. Ley, Y. Chen, D.E. Fitzpatrick, and O. May, CHIMIA 2019, 73, 792-802. (https://doi.org/10.2533/chimia.2019.792)
882. A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow Y. Chen, O. May, D. C. Blakemore, and S. V. Ley Org. Lett. 2019, 21, 6140−6144. (https://doi.org/10.1021/acs.orglett.9b02307)
881. Enabling Synthesis in Fragment-Based Drug Discovery by Reactivity Mapping: Photoredox-Mediated Cross-Dehydrogenative Heteroarylation of Cyclic Amines R. Grainger, T. D. Heighten, S. V. Ley, F. Lima, and C. N. Johnson Chem. Sci., 2019, 10, 2264-2271. (http://dx.doi.org/10.1039/c8sc04789h)
880. Direct Oxidation of Csp3−H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow M. Lesieur, C. Battilocchio, R. Labes, J. Jacq, C. Genicot, S. V. Ley and P. Pasau Chem. Eur. J., 2019, 25, 1203-1207. (https://doi.org/10.1002/chem.201805657)
879. Fast continuous alcohol amination employing a hydrogen borrowing protocol
878. Copper Catalysed Arylations of Amines and Alcohols with Boron-Based Acylating ReagentsA.W. Thomas and S.V. Ley, 2009, 121-154 (Ch. 4) in “Modern Acylation Methods” Ed. L. Ackermann ISBN 978-352731937-4.
877. Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow Y. Chen, M. Leonardi, P. Dingwall, R. Labes, P. Pasau, D. C. Blakemore, and S. V. Ley J. Org. Chem., 2018, 83 (24), 15558–15568. (https://doi.org/10.1021/acs.joc.8b02721)
876. Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server D.E. Fitzpatrick, T. Maujean, A.C. Evans, and S.V. Ley Angew. Chem. Int. Ed. 2018, 57, 15128 –15132. (http://dx.doi.org//10.1002/anie.201809080)
875. Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor Y. Chen, D.C. Blakemore, P. Pasau and S.V. Ley Org. Lett. 2018, 20, 6569-6572. (http://dx.doi.org//10.1021/acs.orglett.8b02907)
874. C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow P. Dingwall, A. Greb, L. N. S. Crespin, R. Labes, B. Musio, J.S. Poh, P. Pasau, D. C. Blakemore and S. V. Ley Chem. Comm. 2018, 54, 11685 – 11688. (http://dx.doi.org/10.1039/c8cc06202a)
873. In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system D. E. Fitzpatrick, R. J. Mutton and S. V. Ley React. Chem. Eng., 2018, 3, 799-806. (http://dx.doi.org/10.1039/C8RE00107C)
872. Integrated plug flow synthesis and crystallisation of pyrazinamide, C. D. Scott, R. Labes, M. Depardieu, C. Battilocchio, M. G. Davidson, S. V. Ley, C. C. Wilson and K. Robertson React. Chem. Eng., 2018, 3, 631-634. (http://dx.doi.org/10.1039/C8RE00087E)
871. Immobilised Reagents and Multistep Processes, S.V. Ley, D.L. Browne, and M. O’Brien Science of Synthesis, 2018, 9, 273-312 in Flow Chemistry in Organic Synthesis, Ed. T.F. Jamison and G. Koch, Georg Thieme Verlag KG, Stuttgart, Germany, ISBN 978-3-13-242331-2. (http://dx.doi.org// 10.1055/sos-SD-228-00177).
870. Preparation of homoallylic amines via a three-component coupling process
869. Engineering Chemistry to Enable Bioactive Small Molecule Discovery S.V.Ley, D. Fitzpatrick and C. Battilocchio 2018, 184-218 (Ch. 8) in Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, Ed. N.J. Westwood and A. Nelson, ISBN 978-1-78262-948-1. (http://dx.doi.org/10.1039/9781788012805-00184)
868. Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone M.O’Brien, A. Weber, G. Hardy, S.V. Ley Tetrahedron, 2018, 74, 5319-5329
867. A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles E. Godineau, C. Battilocchio, M. Lehmann, S. V. Ley, R. Labes, L. Birnoschi, S. Subramanian, C. S. Prasanna, A. Gorde, M. Kalbagh, V. Khade, A. Scherrer, and A. C. O’Sullivan Org. Process Res. Dev. 2018, 22, 955-962
866. Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow F. Lima, L. Grunenberg, H.B.A. Rahman, R. Labes, J. Sedelmeier and S.V. Ley Chem. Commun., 2018, 54, 5606-5609
865. Engineering chemistry for the future of organic synthesis D.E. Fitzpatrick and S.V. Ley Tetrahedron, 2018, 74, 3087-3100
864. Engineering chemistry for the future of organic synthesis S.V. Ley Tetrahedron, 2018, 74, 3085(Preface)
863. Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry D. J. Ritson, C. Battilocchio, S.V. Ley and J. D. Sutherland Nature Communications 2018, 9, 1821[DOI:10.1038/s41467-018-04147-2 | www.nature.com/naturecommunications]
862. The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony Steven V. Ley Angew. Chem. Int. Ed. 2018, 57, 5182 – 5183
861. Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species J. A. Forni, S-H. Lau, J-S. Poh, C. Battilocchio, S.V. Ley and J.C. Pastre Synlett 2018, 29, 825–829
860. Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides J. Döbber, M. Pohl, S. V. Ley and B. Musio React.Chem.Eng., 2018, 3, 8–12
859. Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow B. Musio, E. Gala, and S. V. Ley ACS Sustainable Chem. Eng. 2018, 6, 1489−1495
858. A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross-Coupling Reactions A. Greb, J-S. Poh, S. Greed, C. Battilocchio, P. Pasau, D. C. Blakemore and S. V. Ley Angew. Chem. Int. Ed. 2017, 56, 16602 –16605
857. Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives L.N.S. Crespin, A. Greb, D.C. Blakemore, and S.V. Ley J. Org. Chem. 2017, 82, 13093−13108
856. Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines R. Labes, D. González-Calderón, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J. A. Rincón, and S. V. Ley, Synlett 2017, 28, 2855-2858
855. Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides M.A. Kabeshov, B. Musio and S.V. Ley, React. Chem. Eng., 2017, 2, 822-825
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters F. Lima, U.K. Sharma, L. Grunenberg, D. Saha, S. Johannsen, J. Sedelmeier, E.V. Van der Eycken and S.V. Ley, Angew. Chem. Int. Ed., 2017, 56, 15136-15140
853. Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines C. Battilocchio, F. Bosica, S.M. Roew, B.L. Abreu, E. Godineau, M. Lehmann and S.V. Ley, Org. Process Res. Dev., 2017, 21, 1588-1594
852. Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols R. Labes, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón, K. Binder and S.V. Ley, Org. Process. Res. Dev., 2017, 21, 1419-1422
851. Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids C. Bomio, M.A. Kabeshov, A.R. Lit, S-H. Lau, J. Ehlert, C. Battilocchio and S.V. Ley, Chem. Sci., 2017, 8, 6071-6075
850. A new methodology for incorporating chiral linkers into stapled peptides J.C. Serrano, J. Sipthorp, W. Xu, L.S. Itzhaki and S.V. Ley, Chem. Bio. Chem., 2017, 18, 1066-1071
849. Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S.V. Ley, React. Chem. Eng., 2017, 2, 295-298
848. Utilization of flow chemistry in catalysis: new avenues for the selective synthesis of bis(indolyl)methanes S.S. Mohapatra, Z.E. Wilson, S. Roy, S.V. Ley, Tetrahedron, 2017, 73, 1812-1819
847. One-pot acid-Catalyzed ring-opening/cyclization/oxidation of aziridines with N-tosylhydrazones: access to 1,2,4-triazines L. Crespin, L. Biancalana, T. Morack, D.C. Blakemore, S.V. Ley Org. Lett., 2017, 19, 1084-1087
846. Rapid asymmetric synthesis of disubstituted allenes by coupling of flow-generated diazo compounds and propargylated amines J-S. Poh, S. Makai, T. v.Keutz, D.N. Tran, C. Battilocchio, P. Pasau, S.V. Ley Angew. Chem. Int. Ed. 2017, 56, 1864-1868
845. Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor C. Battilocchio, S-H. Lau, J.M. Hawkins, S.V. Ley Org. Synth. 2017, 94, 34-45
844. On the synthesis and reactivity of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones C.L. Sutherell and S.V. Ley Synthesis, 2017, 49, 135-144
843. Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform D.E. Fitzpatrick and S.V. Ley, React. Chem. Eng. 2016, 1, 629-635
842. Visible light activation of boronic esters enables efficient photoredox C(sp2)-C(sp3) cross-couplings in flow F. Lima, M.A. Kabeshov, D.N. Tran, C. Battilocchio, J. Sedelmeier, G. Sedelmeier, B. Schenkel, S.V. Ley, Angew. Chem. Int. Ed. 2016, 55, 14085-14089
841. The total synthesis of the bioactive natural product Plantazolicin A and its biosynthetic precursor Plantazolicin B S. Fenner, Z.E. Wilson, S.V. Ley, Chem. Eur. J. 2016, 22, 15902-15912
840. A multicomponent approach for the preparation of homoallylic alcohols J-S. Poh, S-H. Lau, I.G. Dykes, D.N. Tran, C. Battilocchio, S.V. Ley, Chem. Sci. 2016, 7, 6803-6807
839. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia S. Picaud, K. Leonards, J-P. Lambart, O. Dovey, C. Wells, O. Federov, O. Monteiro, T. Fujisawa, C-Y. Wang, H. Lingard, C. Tallant, N. Nikbin, L. Guetzoyan, R.J. Ingham, S.V. Ley, P. Brennan, S. Müller, A. Samsonova, A-C. Gingras, J. Schwaller, G. Vassiliou, S. Knapp, P. Filippakopoulos, Science Adv. 2016, 2, e1600760
838. Flow Chemistry in Europe V. Hessel and S.V. Ley, J. Flow. Chem., 2016, 6, 135
837. Combination of enabling technologies to improve and describe the stereoselectivity of Wolff–Staudinger cascade reaction B. Musio, F. Mariani, E.P. Sliwinski, M.A. Kabeshov, H. Odajima, S.V. Ley, Synthesis, 2016, 48, 3515-3526
836. Continuous processing and efficient in situ reaction monitoring of hypervalent iodine(III) mediated cyclopropanation using benchtop NMR spectroscopy B. Ahmed-Omer, E. Sliwinski, J.P. Cerroti, S.V Ley, Org. Process Res. Dev. 2016, 20, 1603-1614
835. Taming hazardous chemistry by continuous flow technology M. Movsisyan, E.I.P. Delbeke, J.K.E.T. Berton, C. Battilocchio, S.V. Ley, C.V. Stevens, Chem. Soc. Rev. 2016, 45, 4892-4928
834. Editorial – flow chemistry and catalysis S.V. Ley, Catal. Sci. Technol. 2016, 6, 4676-4677
833. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation J-S. Poh, C. García-Ruiz, A. Zúñiga, F. Meroni, D.C. Blakemore, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2016, 14, 5983-5991
832. Controlled generation and use of CO in flow S.V.F. Hansen, Z.E. Wilson, T. Ulven, S.V. Ley React. Chem. Eng. 2016, 1, 280-287
831. Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex C.L. Sutherell, C. Tallant, O.P Monteiro, C. Yapp, J.E. Fuchs, O. Fedorov, P. Siejka, S. Müller, S. Knapp, J.D. Brenton, P.E. Brennan, S.V. Ley J. Med. Chem. 2016, 59, 5095-5101
830. Solvent-free continuous operations using small footprint reactors: a key approach for process intensification T. Ouchi, R.J. Mutton, V. Rojas, D.E. Fitzpatrick, D.G. Cork, C. Battilocchio, S.V. Ley ACS Sustainable Chem. Eng. 2016, 4, 1912-1916
829. Enabling technologies for the future of chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley ACS Central Science 2016, 2, 131-138
828. Iterative reactions of transient boronic acids enable sequential C-C bond formation C. Battilocchio, F. Feist, A. Hafner, M. Simon, D.N. Tran, D.M. Allwood, D.C. Blakemore, S.V. Ley Nature Chem. 2016, 8, 360-367
827. Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry D. Lücke, T. Dalton, S.V. Ley, Z.E. Wilson Chem. Eur. J. 2016, 22, 4206-4217
826. (S)-5-Pyrrolidin-2-yltetrazole and (R)-5-Pyrrolidin-2-yltetrazole Second Update R.J. Mutton, S.V. Ley, Electronic Encyclopaedia of Reagents in Organic Synthesis. Ed. L.A. Paquette 2016
825. A novel internet-based reaction monitoring, Control and autonomous self-optimization platform for chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley Org. Process. Res. Dev 2016, 20, 386-394
824. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process J-S. Poh, D.L. Browne, S.V. Ley React. Chem. Eng. 2016, 1, 101-105
823. An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins A. Brahma, B. Musio, U. Ismayilova, N. Nikbin, S.B. Kamptmann, P. Siegert, G.E. Jeromin, S.V. Ley, M. Pohl Synlett 2016, 27, 262-266
822. Dynamic flow synthesis of porous organic cages M.E. Briggs, A.G. Slater, N. Lunt, S. Jiang, M.A. Little, R.L. Greenaway, T. Hasell, C. Battilocchio, S.V. Ley, A.I. Cooper Chem. Commun. 2015, 51, 17390-17393
821. Synthesis of a precursor to sacubitril using enabling technologies S-H. Lau, S.L. Bourne, B. Martin, B. Schenkel, G. Penn, S.V. Ley Org. Lett. 2015, 17, 5436-5439
820. The ‘Internet of Chemical Things‘ S.V. Ley, D.E. Fitzpatrick, R.J. Ingham, N. Nikbin Beilstein Magazine 2015, 1, 11-12
819. Callipeltosides A, B and C: total syntheses and structural confirmation J.R. Frost, C.M. Pearson, T.M. Snaddon, R.A. Booth, R.M. Turner, J. Gold, D.M. Shaw, M.J. Gaunt, S.V. Ley Chem. Eur. J. 2015, 21, 13261-13277
818. Machine-assisted organic synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 2015, 54, 10122-10136
817. Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors De Lucia, O Méndez Lucio, B. Musio, A. Bender, M. Listing, S. Dennhardt, A. Koeberle, U. Garscha, R. Rizzo, S. Manfredini, O. Werz, S.V. Ley Eur. J. Med. Chem. 2015, 101, 573-583
Corrigendum to Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors
816. A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1 L. de c. Alves, A.L. Desiderá, K.T. de Oliveira, S. Newton, S.V. Ley, T.J Brocksom Org. Biomol. Chem. 2015, 13, 7633-7642
815. Continuous flow metathesis for direct valorization of food waste: an example of cocoa butter triglyceride C. Schotten, D. Plaza, S. Manzini, S.P. Nolan, S.V. Ley, D.L. Browne, A. Lapkin ACS Sustainable Chem. Eng. 2015, 3, 1453-1459
814. Machines vs malaria: a flow-based preparation of the drug candidate OZ439 S-H Lau, A. Galván, R.R. Merchant, C. Battilocchio, J.A. Souto, M.B. Berry, S.V. Ley Org. Lett. 2015, 17, 3218-3221
813. Modeling mesoscale reactors for the production of fine chemicals P.W. Witt, S. Somasi, I. Khan, D.W. Blaylock, J.A. Newby, S.V. Ley Chem. Eng. J. 2015, 278, 353-362
812. A versatile room-temperature route to di- and trisubstituted allenes using flow-generated diazo compounds J.S. Poh, D.N. Tran, C. Battilocchio, J.M Hawkins, S.V. Ley Angew. Chem. Int. Ed. 2015, 54, 7920-7923
811. Generation of reactive ketenes under flow conditions through zinc-mediated dehalogenation A. Hafner, S.V. Ley Synlett, 2015, 26, 1470-1474
810. Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods S.B. Kamptmann, S.V. Ley Aust. J. Chem. 2015, 68, 693-696
809. Development of a web-based platform for studying lithiation reactions in silico M.A. Kabeshov, E. Sliwinski, D.E. Fitzpatrick, B. Musio, J.A. Newby, W.D.W. Blaylock, S.V. Ley Chem. Commun. 2015, 51, 7172-7175
808. Development of a flow method for the hydroboration/oxidation of olefins J.A. Souto, R.A. Stockman, S.V.Ley Org. Biomol. Chem. 2015, 13, 3871-3877
807. Design, synthesis and evaluation of tetra substituted pyridines as potent 5-HT2C receptor agonists G. Rouquet, D.E. Moore, M. Spain, D.M. Allwood, C. Battilocchio, D.C. Blakemore, P.V. Fish, S. Jenkinson, A.S. Jessiman, S.V. Ley, G. McMurray, R.A.Storer, ACS Med. Chem. Lett. 2015, 6, 329-333
806. Chemistry in a changing world S.V. Ley, R.M. Myers, D.E. Fitzpatrick L’Actualite Chimique, Fevrier-Mars 2015, 393-394, 96-101
805. Organic synthesis: march of the machines S.V. Ley, D.E.Fitzpatrick, R.J. Ingham, R.M. Myers Angew. Chem. Int. Ed. 2015, 54, 3449-3464
804. Cyclopropanation using flow generated diazo compounds N.M. Roda-Monsalvez, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M.Hawkins, S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554
803. Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor M. Brzozowski, M. O’Brien, S.V. Ley, A. Polyzos Acc. Chem. Res. 2015, 48, 349-362
802. Back pressure regulation of slurry-forming reactions in continuous flow B.J. Deadman, D.L. Browne, I.R. Baxendale, S.V. Ley Chem. Eng. Technol. 2015, 38, 259-264
801. Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds D.N. Tran, C. Battilocchio, S. Lou, J. M. Hawkins, S.V. Ley Chem. Sci. 2015, 6, 1120-1125
800. Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B Z.E. Wilson, S. Fenner, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 1284-1288
