Publications | Professor Steven V. Ley Research Group

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Currently displaying 221 - 240 of 1071 publications

On being green: Can flow chemistry help?

SV Ley

Chemical Record

(2012)

12

378

(doi: 10.1002/tcr.201100041)

A total synthesis of the ammonium ionophore, (-)-enniatin B

DX Hu, M Bielitza, P Koos, SV Ley

Tetrahedron Letters

(2012)

53

4077

(doi: 10.1016/j.tetlet.2012.05.110)

A "Catch-React-Release" Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

RJ Ingham, E Riva, N Nikbin, IR Baxendale, SV Ley

Org Lett

(2012)

14

3920

(doi: 10.1021/ol301673q)

Continuous flow reaction monitoring using an on-line miniature mass spectrometer.

DL Browne, S Wright, BJ Deadman, S Dunnage, IR Baxendale, RM Turner, SV Ley

Rapid Commun Mass Spectrom

(2012)

26

1999

(doi: 10.1002/rcm.6312)

Establishing a Flow Process to Coumarin‐8‐Carbaldehydes as Important Synthetic Scaffolds

J Zak, D Ron, E Riva, HP Harding, BCS Cross, IR Baxendale

Chemistry – A European Journal

(2012)

18

9901

(doi: 10.1002/chem.201201039)

On Being Green: Can Flow Chemistry Help?

SV Ley

Chemical record (New York, N.Y.)

(2012)

12

378

(doi: 10.1002/tcr.201100041)

Asymmetric homogeneous hydrogenation in flow using a tube-in-tube reactor

S Newton, SV Ley, EC Arcé, DM Grainger

Advanced Synthesis & Catalysis

(2012)

354

1805

(doi: 10.1002/adsc.201200073)

Rotamers or Diastereomers? An Overlooked NMR Solution

DX Hu, P Grice, SV Ley

The Journal of organic chemistry

(2012)

77

5198

(doi: 10.1021/jo300734r)

Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations

S Ley, D Browne, M O'Brien, P Koos, P Cranwell, A Polyzos

Synlett

(2012)

23

1402

(doi: 10.1055/s-0031-1290963)

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

C Battilocchio, IR Baxendale, M Biava, MO Kitching, SV Ley

Organic Process Research & Development

(2012)

16

798

(doi: 10.1021/op300084z)

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration

PB Cranwell, M O'Brien, DL Browne, P Koos, A Polyzos, M Peña-López, SV Ley

Organic & biomolecular chemistry

(2012)

10

5774

(doi: 10.1039/c2ob25407g)

The Lab of the Future The importance of remote monitoring and control

MD Hopkin, IR Baxendale, SV Ley

Chimica Oggi Chemistry Today

(2012)

30

24

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1

TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers

Bioorganic and Medicinal Chemistry

(2012)

20

1749

(doi: 10.1016/j.bmc.2012.01.010)

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

BCS Cross, PJ Bond, PG Sadowski, BK Jha, J Zak, JM Goodman, RH Silverman, TA Neubert, IR Baxendale, D Ron, HP Harding

Proceedings of the National Academy of Sciences of the United States of America

(2012)

109

E869

(doi: 10.1073/pnas.1115623109)

Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands

C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin

Synthesis

(2012)

44

635

(doi: 10.1055/s-0031-1289676)

A-Ring Dihalogenation Increases the Cellular Activity of Combretastatin-Templated Tetrazoles

TM Beale, DM Allwood, A Bender, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers, JW Shearman, J Temple, J Unger, CA Watts, J Xian

ACS medicinal chemistry letters

(2012)

3

177

(doi: 10.1021/ml200149g)

Scale-Up of Flow-Assisted Synthesis of C 2-Symmetric Chiral PyBox Ligands

R Martin, C Battilocchio, M Baumann, I Baxendale, M Biava, M Kitching, S Ley, S Ohnmacht, N Tappin

Synthesis

(2012)

2012

635

(doi: 10.1055/s-0031-1289676)

Scale-Up of Flow-Assisted Synthesis of C₂-Symmetric Chiral PyBox Ligands

R Martin, C Battilocchio, M Baumann, I Baxendale, M Biava, M Kitching, S Ley, S Ohnmacht, N Tappin

Synthesis

(2012)

2012

635

(doi: 10.1055/s-0031-1289676)

A total synthesis of millingtonine a

J Wegner, SV Ley, A Kirschning, A-L Hansen, JM Garcia, IR Baxendale

Org Lett

(2012)

14

696

(doi: 10.1021/ol203158p)

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.

TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers

Bioorganic & medicinal chemistry

(2012)

20

1749

(doi: 10.1016/j.bmc.2012.01.010)

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140