Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Total Synthesis of Avermectin B1a: Final Coupling Reactions and the Total Synthesis of Avermectin B1a Aglycone

A ARMSTRONG, SV LEY, A MADIN, S MUKHERJEE

Synlett

(1990)

1990

328

(doi: 10.1055/s-1990-21080)

TOTAL SYNTHESIS OF AVERMECTIN B1A - SYNTHESIS OF THE C-11-C25 SPIROACETAL FRAGMENT

D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN

Synlett

(1990)

1990

326

(doi: 10.1055/s-1990-21079)

TOTAL SYNTHESIS OF AVERMECTIN B1A - PLANNING OF THE SYNTHESIS AND PREPARATION OF THE C1-C10 SOUTHERN HYDROBENZOFURAN FRAGMENT

A ARMSTRONG, SV LEY

Synlett

(1990)

1990

323

(doi: 10.1055/s-1990-21078)

Total Synthesis of Avermectin B1a: Synthesis of the CarbohydrateBis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone

MJ FORD, JG KNIGHT, SV LEY, S VILE

Synlett

(1990)

1990

331

(doi: 10.1055/s-1990-21081)

10.1007/BF00352576

WM Blaney, MSJ Simmonds, SV Ley, JC Anderson, PL Toogood

CrossRef Listing of Deleted DOIs

(1990)

55

149

(doi: 10.1111/j.1570-7458.1990.tb01358.x)

Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae.

MSJ Simmonds, WM Blaney, SV Ley, JC Anderson, PL Toogood

CrossRef Listing of Deleted DOIs

(1990)

55

169

(doi: 10.1007/bf00352578)

A SIMPLE, ONE-POT, GLYCOSIDATION PROCEDURE VIA (1-IMIDAZOLYLCARBONYL) GLYCOSIDES AND ZINC BROMIDE

MJ FORD, SV LEY

Synlett

(1990)

1990

255

(doi: 10.1055/s-1990-21053)

Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes

M CARUSO, JG KNIGHT, SV LEY

Synlett

(1990)

1990

224

(doi: 10.1055/s-1990-21044)

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a

D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN

Tetrahedron Letters

(1990)

31

3445

(doi: 10.1016/S0040-4039(00)97418-5)

Neo-clerodane insect antifeedants from Scutellaria galericulata

MD COLE, JC ANDERSON, WM BLANEY, LE FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS

Phytochemistry

(1990)

29

1793

(doi: 10.1016/0031-9422(90)85018-B)

Research Interest Groups

Synthetic Chemistry

Materials Chemistry

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140