Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Chapter 7 The Champagne Route to Avermectins and Milbemycins

SV Ley, A Armstrong

(1991)

237

(doi: 10.1016/b978-0-08-092430-4.50013-5)

NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES

SV LEY, AJ REDGRAVE, LL YEUNG

INOSITOL PHOSPHATES AND DERIVATIVES

(1991)

463

132

DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE

DS BROWN, P CHARREAU, SV LEY

SYNLETT

(1990)

749

An efficient three-step synthesis of L-(-)-oleandrose from (S)-(-)-methyl lactate

MJ FORD, SV LEY

Synlett

(1990)

1990

771

(doi: 10.1055/s-1990-21247)

Direct Substitution of 2-Phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by Alkyl Organometallic Reagents in Dichloromethane

DS Brown, P Charreau, SV Ley

Synlett

(1990)

1990

749

(doi: 10.1055/s-1990-21237)

A new ruthenium( VI ) oxidant: preparation, X -ray crystal structure, and properties of (Ph 4 P)[RuO 2 (OAc)Cl 2 ]

WP GRIFFITH, JM JOLLIFFE, SV LEY, DJ WILLIAMS

Journal of the Chemical Society Chemical Communications

(1990)

1219

(doi: 10.1039/C39900001219)

SYNTHESIS OF BIOLOGICALLY-ACTIVE CYCLITOLS VIA MICROBIAL OXIDATION OF BENZENE

SV LEY, AJ REDGRAVE

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(1990)

200

NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES

SV LEY

ABSTR PAP AM CHEM S

(1990)

200

USE OF MICROBIAL OXIDANTS FOR THE PREPARATION OF INOSITOL DERIVATIVES AND RELATED CYCLITOLS

SV LEY

ABSTR PAP AM CHEM S

(1990)

200

123

Microbial Oxidation in Synthesis: Concise Preparation of (+)-Conduritol F from Benzene

SV LEY, AJ REDGRAVE

Synlett

(1990)

1990

393

(doi: 10.1055/s-1990-21102)

Research Interest Groups

Synthetic Chemistry

Biological

Materials Chemistry

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

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