Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

345

(doi: 10.1016/s0040-4039(00)95725-3)

The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

3019

(doi: 10.1016/s0040-4039(00)96273-7)

SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG

C Greck, P Grice, AB Jones, SV Ley

Tetrahedron Letters

(1987)

5759

(doi: 10.1016/s0040-4039(00)96834-5)

Application of ultrasound to the preparation of tricarbonyliron diene complexes

SV Ley, CMR Low, AD White

Journal of Organometallic Chemistry

(1986)

302

c13

(doi: 10.1016/0022-328x(86)80072-9)

PREPARATION OF 2-SUBSTITUTED PYRROLES AND INDOLES BY REGIOSELECTIVE ALKYLATION AND DEPROTECTION OF 1-(2-TRIMETHYLSILYLETHOXYMETHYL)PYRROLE AND 1-(2-TRIMETHYLSILYLETHOXYMETHYL) INDOLE

MP Edwards, AM Doherty, SV Ley, HM Organ

Tetrahedron

(1986)

3723

(doi: 10.1016/s0040-4020(01)87342-7)

The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction

G Brussani, SV Ley, JL Wright, DJ Williams

J CHEM SOC PERK T 1

(1986)

303

(doi: 10.1039/p19860000303)

Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V

SE de Laszlo, SV Ley, RA Porter

Chemical Communications

(1986)

344

(doi: 10.1039/C39860000344)

X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin

HB Broughton, SV Ley, AMZ Slawin, DJ Williams, ED Morgan

Chemical Communications

(1986)

(doi: 10.1039/c39860000046)

Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: synthesis of the c-11 to c-25 fragment of the milbemycins

C Greek, P Grice, SV Ley, A Wonnacott

Tetrahedron Letters

(1986)

5277

(doi: 10.1016/s0040-4039(00)85190-4)