Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .7. PREPARATION OF AN OPTICALLY PURE HYDROXYACETAL EPOXIDE RELATED TO AZADIRACHTIN

JC ANDERSON, SV LEY

Tetrahedron Letters

(1990)

3437

(doi: 10.1016/S0040-4039(00)97416-1)

SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS

SV LEY

RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II

(1990)

Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene

SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD

Tetrahedron

(1990)

4995

(doi: 10.1016/S0040-4020(01)85605-2)

Neo-clerodane insect antifeedants from Scutellaria galericulata

MD COLE, JC ANDERSON, WM BLANEY, LE FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS

Phytochemistry

(1990)

1793

(doi: 10.1016/0031-9422(90)85018-B)

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a

D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN

Tetrahedron Letters

(1990)

3445

(doi: 10.1016/S0040-4039(00)97418-5)

ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES

RW BATES, D DIEZMARTIN, WJ KERR, JG KNIGHT, SV LEY, A SAKELLARIDIS

Tetrahedron

(1990)

4063

(doi: 10.1016/S0040-4020(01)90541-1)

TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols

WP Griffith, SV Ley

Aldrichimica Acta

(1990)

Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants.

JC ANDERSON, SV LEY

Tetrahedron Letters

(1990)

431

(doi: 10.1016/s0040-4039(00)94574-x)

Direct substitution of 2-benzenesulphonylpiperidines and - Pyrrolidines by carbon nucleophiles: Synthesis of the pyrrolidine alkaloid ruspolinone

DS BROWN, T HANSSON, SV LEY

Synlett

(1990)

1990

(doi: 10.1055/s-1990-20983)

ENANTIOSELECTIVE SYNTHESIS OF THE C3-C11 HYDROCARBON FRAGMENT OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI 139603)