Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes.

RW BATES, R FERNANDEZMORO, SV LEY

Tetrahedron Letters

(1991)

2651

(doi: 10.1016/s0040-4039(00)78809-5)

Use of phenylsulphonylmethano ethers in synthesis: A new versatile route to substituted cyclic ethers

P CHARREAU, SV LEY, TM VETTIGER, S VILE

Synlett

(1991)

1991

415

(doi: 10.1055/s-1991-20747)

Use of 2-phenylsulphonyl cyclic ethers in the preparation of tetrahydropyran and tetrahydrofuran acetals and in some glycosidation reactions.

DS BROWN, SV LEY, S VILE, M THOMPSON

Tetrahedron

(1991)

1329

(doi: 10.1016/S0040-4020(01)86389-4)

Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids norruspoline and ruspolinone

DS BROWN, P CHARREAU, T HANSSON, SV LEY

Tetrahedron

(1991)

1311

(doi: 10.1016/s0040-4020(01)86388-2)

Total synthesis of the anthelmintic macrolide avermectin B1a

SV LEY, A ARMSTRONG, D DIEZMARTIN, MJ FORD, P GRICE, JG KNIGHT, HC KOLB, A MADIN, CA MARBY, S MUKHERJEE, AN SHAW, AMZ SLAWIN, S VILE, AD WHITE, DJ WILLIAMS, M WOODS

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1991)

667

(doi: 10.1039/p19910000667)

SYNTHESIS OF TETRAHYDROPYRAN-CONTAINING NATURAL-PRODUCTS

SV LEY

HETEROCYCLES IN BIO-ORGANIC CHEMISTRY

(1991)

NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES

SV LEY, AJ REDGRAVE, LL YEUNG

ACS SYMPOSIUM SERIES

(1991)

463

132

The Champagne Route to Avermectins and Milbemycins

SV Ley, A Armstrong

Strategies and Tactics in Organic Synthesis

(1991)

237

(doi: 10.1016/b978-0-08-092430-4.50013-5)

SYNTHESIS OF INSECT ANTIFEEDANTS

SV LEY

PESTICIDE CHEMISTRY : ADVANCES IN INTERNATIONAL RESEARCH, DEVELOPMENT, AND LEGISLATION

(1991)

Microbial Oxidation in Synthesis: Preparation of Novel 3-Substitutedcis-Cyclohexa-3,5-diene-1,2-diol Derivatives from (1S,2S)-3-Bromocyclohexa-3,5-diene-1,2-diol

SV LEY, AJ REDGRAVE, SC TAYLOR, S AHMED, DW RIBBONS

Synlett

(1991)

1991

741

(doi: 10.1055/s-1991-34764)