Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
Tetrahedron: Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-j)
Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination
Synlett
(1995)
1995
1017
(doi: 10.1055/s-1995-5164)
Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues.
CrossRef Listing of Deleted DOIs
(1995)
77
69
(doi: 10.1007/bf02383020)
Dispiroketals in synthesis (Part 18) 1 : Regioselective and enantioselective protection of symmetric polyol substrates using an enantiopure (2 S,2' S)-Dimethyl- bis -dihydropyran
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1995)
210
24
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
Tetrahedron
(1995)
51
7755
(doi: 10.1016/0040-4020(95)00395-o)
The synthesis and assay of radiolabelled benzene derivatives
Tetrahedron
(1995)
51
7741
(doi: 10.1016/0040-4020(95)00394-N)
Tuning the reactivity of glycosides: Efficient one-pot oligosaccharide synthesis
Synlett
(1995)
1995
781
(doi: 10.1055/s-1995-5052)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
SYNLETT
(1995)
781
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .19. A POTENTIAL RELAY ROUTE FOR THE SYNTHESIS OF AZADIRACHTIN
Tetrahedron
(1995)
51
6591
(doi: 10.1016/0040-4020(95)00297-L)
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