Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

DISPIROKETALS IN SYNTHESIS .8. REGIOSELECTIVE PROTECTION OF D-GLUCOPYRANOSE SUBSTRATES

DA Entwistle, AB Hughes, SV Ley, G Visentin

Tetrahedron Letters

(1994)

777

(doi: 10.1016/s0040-4039(00)75815-1)

TOWARDS THE SYNTHESIS OF THE C-37-C-42 FRAGMENT OF RAPAMYCIN - INTRAMOLECULAR REACTIONS OF ALLYL SILANES WITH OXONIUM IONS GENERATED FROM ALPHA-ALKOXY SULFONES

SV Ley, C Kouklovsky

Tetrahedron

(1994)

835

(doi: 10.1016/S0040-4020(01)80798-5)

BIOSYNTHESIS OF TETRONASIN .1. INTRODUCTION AND INVESTIGATION OF THE DIKETIDE AND TRIKETIDE INTERMEDIATES BOUND TO THE POLYKETIDE SYNTHASE

HC Hailes, CM Jackson, PF Leadlay, SV Ley, J Staunton

Tetrahedron Letters

(1994)

307

(doi: 10.1016/s0040-4039(00)76539-7)

Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase

HC Hailes, S Handa, PF Leadlay, IC Lennon, SV Ley, J Staunton

Tetrahedron Letters

(1994)

311

(doi: 10.1016/s0040-4039(00)76540-3)

Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)

G-J Boons, IC Lennon, SV Ley, ESE Owen, J Staunton, DJ Wadsworth

Tetrahedron Letters

(1994)

323

(doi: 10.1016/s0040-4039(00)76543-9)

Biosynthesis of tetronasin: Part 3 preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin

HC Hailes, S Handa, PF Leadlay, IC Lennon, SV Ley, J Staunton

Tetrahedron Letters

(1994)

315

(doi: 10.1016/S0040-4039(00)76541-5)

Two new routes to the C19C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603)

G-J Boons, DS Brown, JA Clase, IC Lennon, SV Ley

Tetrahedron Letters

(1994)

319

(doi: 10.1016/s0040-4039(00)76542-7)

Dispiroketals in synthesis (Part 15): Simultaneous enantioselective and regioselective protection of glycerol by reaction with C2 symmetric (4S,4'S)-dimethyl-bis-dihydropyran

C Genicot*, S Ley

Synthesis

(1994)

1994

1275

(doi: 10.1055/s-1994-25680)

DISPIROKETALS IN SYNTHESIS .9. RESOLUTION OF 1,2-DIOLS USING A C-2-SYMMETRICAL DIPHENYLTETRAHYDROBIPYRAN

PJ Edwards, DA Entwistle, SV Ley, DR Owen, EJ Perry

Tetrahedron Asymmetry

(1994)

553

(doi: 10.1016/0957-4166(94)80016-2)