Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Dispiroketals in synthesis (Part 11): Concomitant enantioselective and regioselective protection of 2,5- dibenzoyl-myo-inositol

PJ Edwards, DA Entwistle, C Genicot, KS Kim, SV Ley

Tetrahedron Letters

(1994)

7443

(doi: 10.1016/0040-4039(94)85337-1)

Dispiroketals in synthesis (Part 12): Functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form

BCB Bezuidenhoudt, GH Castle, SV Ley

Tetrahedron Letters

(1994)

7447

(doi: 10.1016/0040-4039(94)85338-x)

DISPIROKETALS IN SYNTHESIS .14. FUNCTIONALIZED DISPIROKETALS AS NEW CHIRAL AUXILIARIES - HIGHLY STEREOSELECTIVE MICHAEL ADDITIONS TO A BIFUNCTIONAL, C-2-SYMMETRICAL CHIRAL AUXILIARY

GH Castle, SV Ley

Tetrahedron Letters

(1994)

7455

(doi: 10.1016/0040-4039(94)85340-1)

SELECTIVE ACYLATION AND ALKYLATION REACTIONS OF DIOLS USING DIBUTYLTIN DIMETHOXIDE (PG 913, 1993)

CJ BOONS, GH CASTLE, JA CLASE, P GRICE, SV LEY, C PINEL

SYNLETT

(1994)

764

Sexual development of malaria parasites is inhibited in vitro by the Neem extract Azadirachtin, and its semi-synthetic analogues

I Jones

FEMS Microbiology Letters

(1994)

120

267

(doi: 10.1016/0378-1097(94)90482-0)

Model studies towards the insect antifeedant Jodrellin A using an organoselenium mediated cyclization reaction

WM Blaney, AC Cuñat, SV Ley, FJ Montgomery, MSJ Simmonds

Tetrahedron Letters

(1994)

4861

(doi: 10.1016/S0040-4039(00)76988-7)

DISPIROKETALS IN SYNTHESIS .10 - FURTHER REACTIONS OF DISPOKE PROTECTED LACTATE AND GLYCOLATE ENOLATES

G-J Boons, R Downham, KS Kim, SV Ley, M Woods

Tetrahedron

(1994)

7157

(doi: 10.1016/s0040-4020(01)85241-8)

STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE C10-C17 CARBON UNIT

SV Ley, J Norman, C Pinel

Tetrahedron Letters

(1994)

2095

(doi: 10.1016/S0040-4039(00)73059-0)

STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - A CONVERGENT AND STEREOSELECTIVE SYNTHESIS OF THE C22-C32 CARBON FRAMEWORK

JC Anderson, SV Ley, SP Marsden

Tetrahedron Letters

(1994)

2087

(doi: 10.1016/S0040-4039(00)73057-7)

STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE CYCLOHEXYL C33-C42 FRAGMENT AND FURTHER COUPLING TO AFFORD THE C22-C42 CARBON UNIT

C Kouklovsky, SV Ley, SP Marsden

Tetrahedron Letters

(1994)

2091

(doi: 10.1016/S0040-4039(00)73058-9)