Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

DISPIROKETALS IN SYNTHESIS .19. DISPIROKETALS AS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTIVE AGENTS FOR SYMMETRICAL CYCLIC AND ACYCLIC POLYOLS

R Downham, PJ Edwards, DA Entwistle, AB Hughes, KS Kim, SV Ley

Tetrahedron Asymmetry

(1995)

2403

(doi: 10.1016/0957-4166(95)00318-j)

Solid Phase Synthesis of Bicyclo[22.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

S Ley*, D Mynett, W-J Koot

Synlett

(1995)

1995

1017

(doi: 10.1055/s-1995-5164)

Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues.

MSJ Simmonds, WM Blaney, SV Ley, JC Anderson, R Banteli, AA Denholm, PCW Green, RB Grossman, C Gutteridge, L Jennens

CrossRef Listing of Deleted DOIs

(1995)

(doi: 10.1111/j.1570-7458.1995.tb01987.x)

DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN

P Edwards, S Ley*

Synlett

(1995)

1995

898

(doi: 10.1055/s-1995-5122)

SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN

SV LEY

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(1995)

210

The synthesis and assay of radiolabelled benzene derivatives

NJ Hales, H Heaney, JH Hollinshead, SV Ley

Tetrahedron

(1995)

7741

(doi: 10.1016/0040-4020(95)00394-N)

Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications

NJ Hales, H Heaney, JH Hollinshead, SV Ley

Tetrahedron

(1995)

7755

(doi: 10.1016/0040-4020(95)00395-O)

Tuning the reactivity of glycosides: Efficient one-pot oligosaccharide synthesis

P Grice, S Ley*, J Pietruszka, H Priepke, E Walther

Synlett

(1995)

1995

781

(doi: 10.1055/s-1995-5052)

CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS

P GRICE, SV LEY, J PIETRUSZKA, HWM PRIEPKE, EPE WALTHER

SYNLETT

(1995)

781

Chemistry of insect antifeedants from Azadirachta Indica (Part 19): 1A potential relay route for the synthesis of azadirachtin

AA Denholm, L Jennens, SV Ley, A Wood

Tetrahedron

(1995)

6591

(doi: 10.1016/0040-4020(95)00297-l)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

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Study at Cambridge

About the University

Research at Cambridge