Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents

J Habermann, SV Ley, JS Scott

Journal of the Chemical Society Perkin Transactions 1

(1998)

3127

(doi: 10.1039/a805997g)

A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society Perkin Transactions 1

(1998)

3125

(doi: 10.1039/a806584e)

A new route to functionalised pi-allyltricarbonyliron lactam complexes from aziridines and their use in stereoselective synthesis and oxidative conversion to beta-lactams

SV Ley, B Middleton

Chemical Communications

(1998)

1995

(doi: 10.1039/a806236f)

Molybdenum(II)- and tungsten(II)-catalyzed allylic substitution

AV Malkov, IR Baxendale, DJ Mansfield, P Kocovsky

ABSTR PAP AM CHEM S

(1998)

216

U548

Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)

SV Ley, DS Brown, JA Clase, AJ Fairbanks, IC Lennon, HMI Osborn, ESE StokeséOwen, DJ Wadsworth

Journal of the Chemical Society, Perkin Transactions 1

(1998)

2259

(doi: 10.1039/a804170i)

Clean three-step synthesis of 4,5-dihydro-1 H -pyrazoles starting from alcohols using polymer supported reagents

F Haunert, MH Bolli, B Hinzen, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1998)

2235

(doi: 10.1039/a803609h)

Use of polymer supported reagents for clean multi-step organic synthesis: Preparation of amines and amine derivatives from alcohols for use in compound library generation

SV Ley, MH Bolli, B Hinzen, A-G Gervois, BJ Hall

J CHEM SOC PERK T 1

(1998)

2239

(doi: 10.1039/a803611j)

Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines

MH Bolli, SV Ley

Journal of the Chemical Society, Perkin Transactions 1

(1998)

2243

(doi: 10.1039/a803612h)

Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols

R Lenz, SV Ley, DR Owen, SL Warriner

Tetrahedron: Asymmetry

(1998)

2471

(doi: 10.1016/s0957-4166(98)00227-4)

Mukaiyama aldol reactions of π-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains.: Not just formal, but genuine 1,7 induction of chirality

SV Ley, B Middleton, JM Worrall

Chemical Communications

(1998)

1339

(doi: 10.1039/a802878h)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge