Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Highly diasteroselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes:: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction (pg 227, 1998)

SV Ley, LR Cox

CHEMICAL COMMUNICATIONS

(1998)

851

Highly diastereoselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes:: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction

SV Ley

Chemical Communications

(1998)

227

(doi: 10.1039/a707153a)

A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols

SV Ley, JM Worrall

Chemical Communications

(1998)

229

(doi: 10.1039/a707155h)

Tuning glycoside reactivity: New tool for efficient oligosaccharide synthesis

NL Douglas, SV Ley, U Lücking, SL Warriner

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1998)

(doi: 10.1039/a705275h)

Synthesis of isoxazolidines using polymer supported perruthenate (PSP)

B Hinzen, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1998)

(doi: 10.1039/a707340b)

Studies Towards the Synthesis of the C29-C51 Fragment of Altohyrtin A

E Fernandez-Megia*, N Gourlaouen, SV Ley, GJ Rowlands

Synlett

(1998)

1998

991

(doi: 10.1055/s-1998-3140)

One-pot synthesis of penta- and hepta-saccharides from monomeric mannose building blocks using the principles of orthogonality and reactivity tuning

L Green*, B Hinzen, SJ Ince, P Langer, SV Ley, SL Warriner

Synlett

(1998)

1998

440

(doi: 10.1055/s-1998-1659)

Double diastereodifferentiation in the Mukaiyama aldol reactions of pi-allyltricarbonyliron lactone complexes: 1,7- vs. 1,2-asymmetric induction

SV Ley, LR Cox, JM Worrall

Journal of the Chemical Society Perkin Transactions 1

(1998)

3349

(doi: 10.1039/a805996i)

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of lactols.

MF Buffet*, DJ Dixon, SV Ley, EW Tate

Synlett

(1998)

1998

1091

(doi: 10.1055/s-1998-1866)

Diastereoselective Anomeric Oxygen to Carbon Rearrangements of Silyl Enol Ether Derivatives of Lactols

DJ Dixon*, SV Ley, EW Tate

Synlett

(1998)

1998

1093

(doi: 10.1055/s-1998-1867)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge