Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

M Caldarelli, J Habermann, SV Ley

Bioorganic & Medicinal Chemistry Letters

(1999)

2049

(doi: 10.1016/S0960-894X(99)00311-X)

Preparation of desymmetrised meso-tartrate derivatives -: synthesis and utility of (R′,R′,R,S)-2,3-butane diacetal protected dimethyl tartrate

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society Perkin Transactions 1

(1999)

1631

(doi: 10.1039/a902733e)

Dispiroketals in synthesis. Part 24. 1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Laine, M Fujita, SV Ley

J CHEM SOC PERK T 1

(1999)

1639

(doi: 10.1039/a900950g)

New building blocks for efficient and highly diastereoselective polyol production - Synthesis and utility of (R ',R ',S,S) and (S ',S ',R,R)-2,3-butane diacetal protected butane tetrol derivatives

JS Barlow, DJ Dixon, AC Foster, SV Ley, DJ Reynolds

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

1627

(doi: 10.1039/a902734c)

Dispiroketals in synthesis. Part 25. 1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Laine, SV Ley