Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

Journal of the Chemical Society Perkin Transactions 1

(1999)

1251

(doi: 10.1039/a901798d)

Dispiroketals in synthesis. Part 25. 1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

1647

(doi: 10.1039/a900951e)

Dispiroketals in synthesis. Part 24. 1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

J CHEM SOC PERK T 1

(1999)

1639

(doi: 10.1039/a900950g)

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1307

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine

DJ Dixon, SV Ley, T Gracza, P Szolcsanyi

J CHEM SOC PERK T 1

(1999)

839

(doi: 10.1039/a809823i)

Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin

AJ Mordue, AJ Nisbet, L Jennens, SV Ley, W Mordue

AZADIRACHTA INDICA A. JUSS.

(1999)

247

Polymer-supported hypervalent iodine reagents in ‘clean’ organic synthesis with potential application in combinatorial chemistry

SV Ley, AW Thomas, H Finch

J CHEM SOC PERK T 1

(1999)

669

(doi: 10.1039/a809799b)

Myocardiac ischemia induced by obstructive sleep apnea in the hypertensive morbidly without known heart disease demonstrated by (SPECT) Te 99m sestamibl preliminary report

A Orea, V Rebollar, M Valencia, M Fernández, M Rosales, A Castaño, C Keirns, J Dorantes, J Sepulveda, S Ley, G García, J Oseguera, O González, J González

HYPERTENSION

(1999)

1303

Prevalence of systemic hyprtension in morbid obesity.: Polysomnographic study.

M Fernández, V Rebollar, J Oseguera, A Orea, M Valencia, C Keirns, J Dorantes, M Reséndiz, M Rosales, R Campos, S Ley, X Gómez, J González-B, B García

HYPERTENSION

(1999)

1280

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in the heart failure (CHF) treatment, effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1088

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

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Study at Cambridge

About the University

Research at Cambridge