Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in the heart failure (CHF) treatment, effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

33

1088

Actions of azadirachtin, a plant allelochemical, against insects

AJ Mordue, MSJ Simmonds, SV Ley, WM Blaney, W Mordue, M Nasiruddin, AJ Nisbet

Pest Management Science

(1999)

54

277

(doi: 10.1002/(SICI)1096-9063(1998110)54:3<277::AID-PS801>3.0.CO;2-I)

Polymer-supported hypervalent iodine reagents in ‘clean’ organic synthesis with potential application in combinatorial chemistry

SV Ley, AW Thomas, H Finch

J CHEM SOC PERK T 1

(1999)

669

(doi: 10.1039/a809799b)

Molybdenum(II)-catalyzed allylation of electron-rich aromatics and heteroaromatics

AV Malkov, SL Davis, IR Baxendale, WL Mitchell, P Kocovský

Journal of Organic Chemistry

(1999)

64

2751

(doi: 10.1021/jo982178y)

Molybdenum(II)- and Tungsten(II)-Catalyzed Allylic Substitution

AV Malkov, IR Baxendale, D Dvorák, DJ Mansfield, P Kocovský

The Journal of organic chemistry

(1999)

64

2737

(doi: 10.1021/jo9821776)

1,7-Induction of chirality in Mukaiyama aldol reactions using π-allyltricarbonyliron lactone and lactam complexes as chiral templates

SV Ley, LR Cox, B Middleton, JM Worrall

Tetrahedron

(1999)

55

3515

(doi: 10.1016/s0040-4020(98)01159-4)

Chemical synthesis of the N-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonensis

A Düffels, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

375

(doi: 10.1039/a809798d)

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

M Caldarelli, J Habermann, SV Ley

J CHEM SOC PERK T 1

(1999)

107

(doi: 10.1039/a809345h)

Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei

DK Baeschlin, AR Chaperon, V Charbonneau, LG Green, SV Ley, U Lücking, E Walther

Angew Chem Int Ed Engl

(1999)

37

3423

(doi: 10.1002/(SICI)1521-3773(19981231)37:24<3423::AID-ANIE3423>3.3.CO;2-9)

Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR

SK Latypov, JM Seco, E Quinoa, R Riguera, E Fernandez-Megia, SV Ley

Chemtracts

(1999)

12

539

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140