Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Deracemization of Baylis-Hillman adducts

SV Ley, F Rodriguez

Chemtracts

(2000)

596

Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]

SV Ley, HMI Osborn

Organic Syntheses

(2000)

212

(doi: 10.15227/orgsyn.077.0212)

Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate

RM Kellogg

Chemtracts

(2000)

Asymmetric molybdenum-catalyzed allylic substitution.

AV Malkov, P Spoor, V Vinader, P Kocovsky

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2000)

219

U132

Untitled - Comment

S Ley

CHEMISTRY IN BRITAIN

(2000)

1,2-diacetals in synthesis:: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei

DK Baeschlin, AR Chaperon, LG Green, MG Hahn, SJ Ince, SV Ley

Chemistry A European Journal

(1999)

172

(doi: 10.1002/(sici)1521-3765(20000103)6:1<172::aid-chem172>3.0.co;2-5)

Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide

D Depré, A Düffels, LG Green, R Lenz, SV Ley, C-H Wong

Chemistry - A European Journal

(1999)

3326

(doi: 10.1002/(sici)1521-3765(19991105)5:11<3326::aid-chem3326>3.3.co;2-h)

Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide

D Depré, A Düffels, LG Green, R Lenz, SV Ley, C Wong

Chemistry A European Journal

(1999)

3326

(doi: 10.1002/(SICI)1521-3765(19991105)5:11<3326::AID-CHEM3326>3.0.CO;2-Q)

Use of the Temporary Connection in Organic Synthesis

LR Cox, SV Ley

(1999)

274

(doi: 10.1002/9783527613526.ch10)

Modified mesoporous silicate MCM-41 materials: immobilised perruthenate - a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen

A Bleloch, BFG Johnson, SV Ley, AJ Price, DS Shephard, AW Thomas

Chemical Communications

(1999)

1907

(doi: 10.1039/a906354d)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge