Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Parallel solution-phase syntheses of functionalised bicyclo-[2.2.2]octanes: Generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants

SV Ley, A Massi

J CHEM SOC PERK T 1

(2000)

3645

(doi: 10.1039/b003129l)

Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate

RM Kellogg

Chemtracts

(2000)

Clean and efficient synthesis of azo dyes using polymer-supported reagents

M Caldarelli, IR Baxendale, SV Ley

Green Chemistry

(2000)

(doi: 10.1039/b000816h)

Reductive decomplexation of pi-allyltricarbonyliron lactone complexes: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols

SV Ley, S Burckhardt, LR Cox, JM Worrall

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

211

(doi: 10.1039/a907630a)

A short and efficient stereoselective synthesis of the potent 5- lipoxygenase inhibitor CMI-977

DJ Dixon, SV Ley, DJ Reynolds, MS Chorghade

Synthetic Communications

(2000)

1955

(doi: 10.1080/00397910008087245)

Deracemization of Baylis-Hillman adducts

SV Ley, F Rodriguez

Chemtracts

(2000)

596

1,2-Diacetals in Synthesis: Total Synthesis of a Glycosylphosphatidylinositol Anchor ofTrypanosoma brucei

DK Baeschlin, AR Chaperon, LG Green, MG Hahn, SJ Ince, SV Ley

Chemistry - A European Journal

(1999)

172

(doi: 10.1002/(sici)1521-3765(20000103)6:1<172::aid-chem172>3.3.co;2-x)

Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide

D Depré, A Düffels, LG Green, R Lenz, SV Ley, C-H Wong

Chemistry A European Journal

(1999)

3326

(doi: 10.1002/(sici)1521-3765(19991105)5:11<3326::aid-chem3326>3.3.co;2-h)

Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide

D Depré, A Düffels, LG Green, R Lenz, SV Ley, C Wong

Chemistry - A European Journal

(1999)

3326

(doi: 10.1002/(SICI)1521-3765(19991105)5:11<3326::AID-CHEM3326>3.0.CO;2-Q)

Use of the Temporary Connection in Organic Synthesis

LR Cox, SV Ley

(1999)

274

(doi: 10.1002/9783527613526.ch10)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge