Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis

C Jamieson, MS Congreve, DF Emiabata-Smith, SV Ley

Synlett

(2000)

2000

1603

(doi: 10.1055/s-2000-7917)

Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation

SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, DA Longbottom, M Nesi, JS Scott, RI Storer, SJ Taylor

Journal of the Chemical Society Perkin Transactions 1

(2000)

3815

(doi: 10.1039/b006588i)

1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-substituted beta-hydroxy carbonyl compounds

SV Ley, EA Wright

J CHEM SOC PERK T 1

(2000)

1677

(doi: 10.1039/b002056g)

The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives

DJ Dixon, SV Ley, EW Tate

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

1829

(doi: 10.1039/a909302h)

Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-( S , S )-( cis -6-methyltetrahydropyran-2-yl)acetic acid, a component of civet

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society Perkin Transactions 1

(2000)

2385

(doi: 10.1039/b001243m)

Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]

SV Ley, HMI Osborn

Organic Syntheses

(2000)

212

Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: an investigation of the reaction mechanism via a double isotopic labelling crossover study

MF Buffet, DJ Dixon, GL Edwards, SV Ley, EW Tate

J CHEM SOC PERK T 1

(2000)

1815

(doi: 10.1039/a909300a)

The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol

SV Ley, S Burckhardt

J CHEM SOC PERK T 1

(2000)

3028

(doi: 10.1039/b005942k)

A short stereoselective total synthesis of the fusarium toxin equisetin.

LT Burke, DJ Dixon, SV Ley, F Rodríguez

Organic Letters

(2000)

3611

(doi: 10.1021/ol006493u)

The total synthesis of the annonaceous acetogenin, muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

Angewandte Chemie

(2000)

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::AID-ANIE3622>3.0.CO;2-H)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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