Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C We thank the EPSRC (D.J.D. and D.J.R.), the Novartis Research Fellowship (S.V.L.), and the BP Research Endowment (S.V.L.) for generous financial support for this work.
Angew Chem Int Ed Engl
(2000)
39
3622
Chemoenzymatic synthesis of l-galactosylated dimeric Sialyl Lewis X structures employing α-1,3-fucosyltransferase V
Bioorg Med Chem
(2000)
8
2519
Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil
Bioorganic & medicinal chemistry letters
(2000)
10
1983
Combined application of analytical techniques for the characterization of polymer supported species.
Journal of combinatorial chemistry
(2000)
2
491
(doi: 10.1021/cc000021p)
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic Probes for glycosyltransferases
Bioorganic and Medicinal Chemistry
(2000)
8
1937
Synthesis of high-mannose type neoglycolipids:: Active targeting of liposomes to macrophages in gene therapy
Chemistry
(2000)
6
1416
Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219
U132
Polymer supported reagents in synthesis: preparation of bicyclo[2.2.2] octane derivates via Tandem Michael addition reactions and subsequent combinatorial decoration.
Journal of Combinatorial Chemistry
(2000)
2
104
(doi: 10.1021/cc9900697)
Rapid assembly of oligosaccharides: 1,2-diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides
Tetrahedron: Asymmetry
(2000)
11
173
A Short and Efficient Stereoselective Synthesis of the Polyhydroxylated Macrolactone (+)-Aspicilin
Organic Letters
(2000)
2
123
(doi: 10.1021/ol991214s)
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