Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of High-Mannose Type Neoglycolipids: Active Targeting of Liposomes to Macrophages in Gene Therapy

A Düffels, LG Green, SV Ley, AD Miller

Chemistry (Weinheim an der Bergstrasse, Germany)

(2000)

1416

(doi: 10.1002/(sici)1521-3765(20000417)6:8<1416::aid-chem1416>3.0.co;2-o)

Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.

AV Malkov, IR Baxendale, M Bella, V Langer, P Kocovsky

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2000)

219

U132

Polymer Supported Reagents in Synthesis: Preparation of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Combinatorial Decoration

SV Ley, A Massi

Journal of combinatorial chemistry

(2000)

104

(doi: 10.1021/cc9900697)

Rapid assembly of oligosaccharides: 1,2-Diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides

DK Baeschlin, LG Green, MG Hahn, B Hinzen, SJ Ince, SV Ley

Tetrahedron: Asymmetry

(2000)

173

(doi: 10.1016/S0957-4166(99)00519-4)

A short and efficient stereoselective synthesis of the polyhydroxylated macrolactone (+)-aspicillin

DJ Dixon, AC Foster, SV Ley

Org Lett

(2000)

123

(doi: 10.1021/ol991214s)

Asymmetric molybdenum-catalyzed allylic substitution.

AV Malkov, P Spoor, V Vinader, P Kocovsky

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2000)

219

U132

New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction

E Diez, SV Ley

Chemtracts

(2000)

592

Deracemization of Baylis-Hillman adducts

SV Ley, F Rodriguez

Chemtracts

(2000)

596

METHYL 2,3-O-(6,6'-OCTAHYDRO-6,6'-BI-2H-PYRAN-2,2'-DIYL)-a-D-GALACTOPYRANOSIDE

SV Ley, HMI Osborn

Organic Syntheses

(2000)

212

(doi: 10.15227/orgsyn.077.0212)

Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A convenient hydroxymethyl anion equivalent

E Fernández-Megía*, SV Ley

Synlett

(2000)

2000

455

(doi: 10.1055/s-2000-6559)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge