Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Approaches to the total synthesis of antascomicin A.
ABSTR PAP AM CHEM S
(2001)
221
U198
Studies toward the total synthesis of rapamycin.
ABSTR PAP AM CHEM S
(2001)
221
U185
Characterization of azadirachtin binding to Sf9 nuclei in vitro
Archives of Insect Biochemistry and Physiology
(2001)
46
78
(doi: 10.1002/arch.11)
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging
Angewandte Chemie International Edition
(2001)
40
1053
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging We gratefully acknowledge financial support from Pfizer Global Research and Development, the University of Ferrara (Italy, Postdoctoral Fellowship to A.M.), the EU (Marie Curie Fellowship to F.R.), and a Novartis Research Fellowship (to S.V.L.).
Angewandte Chemie (International ed. in English)
(2001)
40
1053
Synthesis of New Chiral 2,2‘-Bipyridyl-Type Ligands, Their Coordination to Molybdenum(0), Copper(II), and Palladium(II), and Application in Asymmetric Allylic Substitution, Allylic Oxidation, and Cyclopropanation
Organometallics
(2001)
20
673
(doi: 10.1021/om000850m)
A New Route to Butane-1,2-diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products
Synlett
(2001)
2001
1793
(doi: 10.1055/s-2001-18087)
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
Canadian Journal of Chemistry
(2001)
79
1668
(doi: 10.1139/cjc-79-11-1668)
Solid-Supported Reagents for the Oxidation of Aldehydes to Carboxylic Acids
Synlett
(2001)
2001
1555
(doi: 10.1055/s-2001-17448)
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