Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Solid-supported reagents for the oxidation of aldehydes to carboxylic acids

T Takemoto*, K Yasuda, SV Ley

Synlett

(2001)

2001

1555

(doi: 10.1055/s-2001-17448)

A new route to butane-1,2-diacetals and the development of alternative substitution patterns to facilitate differential protection of the products

SV Ley*, P Michel

Synlett

(2001)

2001

1793

(doi: 10.1055/s-2001-18087)

The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol

DJ Dixon, AC Foster, SV Ley

Canadian Journal of Chemistry

(2001)

1668

(doi: 10.1139/cjc-79-11-1668)

The Development and Application of Supported Reagents for Multi-step Organic Synthesis

IR Baxendale, SV Ley

(2001)

1,2-Diacetals: A new opportunity for organic synthesis

SV Ley, DK Baeschlin, DJ Dixon, AC Foster, SJ Ince, HW Priepke, DJ Reynolds

Chemical Reviews

(2000)

101

(doi: 10.1021/cr990101j)

A rapid approach for the optimisation of polymer supported reagents in synthesis

C Jamieson*, MS Congreve, DF Emiabata-Smith, SV Ley

Synlett

(2000)

2000

1603

(doi: 10.1055/s-2000-7917)

Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation

SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, DA Longbottom, M Nesi, JS Scott, RI Storer, SJ Taylor

Journal of the Chemical Society Perkin Transactions 1

(2000)

3815

(doi: 10.1039/b006588i)

The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol

SV Ley, S Burckhardt

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

3028

(doi: 10.1039/b005942k)

1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-substituted β-hydroxy carbonyl compounds

SV Ley, EA Wright

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

1677

(doi: 10.1039/b002056g)

Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S)-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet

DJ Dixon, SV Ley, EW Tate

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

2385

(doi: 10.1039/b001243m)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge