Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Data mining and the future of chemistry

S Ley

MANUFACTURING CHEMIST

(2001)

New polyethylene glycol polymers as ketal protecting groups - A polymer supported approach to symmetrically substituted spiroketals

R Haag, AG Leach, SV Ley, M Nettekoven, J Schnaubelt

Synthetic Communications

(2001)

2965

(doi: 10.1081/scc-100105668)

Molybdenum(0) and tungsten(0) catalysts with enhanced reactivity for allylic substitution: regioselectivity and solvent effects

AV Malkov, IR Baxendale, DJ Mansfield, P Kočovský

Journal of the Chemical Society, Perkin Transactions 1

(2001)

1234

(doi: 10.1039/b100903f)

Solid-phase reaction monitoring - Chemical derivatization and off-bead analysis

C Kay, OE Lorthioir, NJ Parr, M Congreve, SC McKeown, JJ Scicinski, SV Ley

Biotechnol Bioeng

(2001)

110

(doi: 10.1002/1097-0290(2000)71:2<110::aid-bit1002>3.3.co;2-u)

A New Route to Butane-1,2-diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products

SV Ley*, P Michel

Synlett

(2001)

2001

1793

(doi: 10.1055/s-2001-18087)

Solid-Supported Reagents for the Oxidation of Aldehydes to Carboxylic Acids

T Takemoto*, K Yasuda, SV Ley

Synlett

(2001)

2001

1555

(doi: 10.1055/s-2001-17448)

A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers

IR Baxendale*, A-L Lee, SV Ley

Synlett

(2001)

2001

1482

(doi: 10.1055/s-2001-16783)

The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol

DJ Dixon, AC Foster, SV Ley

Canadian Journal of Chemistry

(2001)

1668

(doi: 10.1139/cjc-79-11-1668)

A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers (Sept, pg 1482, 2001)

IR Baxendale, AL Lee, SV Ley

Synlett

(2001)

2004

A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977

DJ Dixon, SV Ley, DJ Reynolds, MS Chorghade

Indian Journal of Chemistry Section B Organic and Medicinal Chemistry

(2001)

1043

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge