Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Butane-2,3-Diacetal-Desymmetrized Glycolic Acid-A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids.

E Díez, DJ Dixon, SV Ley

Angewandte Chemie International Edition

(2001)

2906

(doi: 10.1002/1521-3773(20010803)40:15<2906::aid-anie2906>3.0.co;2-5)

Development and application of a carbonyl-(13)C-enriched backbone amide linker for solid-phase reaction monitoring.

C Jamieson, MS Congreve, PR Hewitt, JJ Scicinski, SV Ley

ACS Combinatorial Science

(2001)

397

(doi: 10.1021/cc010012w)

Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs.

JJ Scicinski, MS Congreve, C Jamieson, SV Ley, ES Newman, VM Vinader, RA Carr

Journal of Combinatorial Chemistry

(2001)

387

(doi: 10.1021/cc0100114)

New catalysts for olefin metathesis

M Scholl, S Ding, CW Lee, RH Grubbs, PE Brennan, SV Ley, AK Chatterjee, JP Morgan

Chemtracts

(2001)

Approaches to the total synthesis of antascomicin A.

SV Ley, DEA Brittain, JS Barlow, MD Smith, K Yasuda

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2001)

221

U198

Studies toward the total synthesis of rapamycin.

SV Ley, PE Brennan

ABSTR PAP AM CHEM S

(2001)

221

U185

A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging

SV Ley, A Massi, F Rodríguez, DC Horwell, RA Lewthwaite, MC Pritchard, AM Reid

Angewandte Chemie International Edition

(2001)

1053

(doi: 10.1002/1521-3773(20010316)40:6<1053::aid-anie10530>3.0.co;2-d)

A polymer-supported thionating reagent

SV Ley, AG Leach, RI Storer

J CHEM SOC PERK T 1

(2001)

358

(doi: 10.1039/b008814p)

Synthesis of new chiral 2,2 '-bipyridyl-type ligands, their coordination to molybdenum(0), copper(II), and palladium(II), and application in asymmetric allylic substitution, allylic oxidation, and cyclopropanation

AV Malkov, IR Baxendale, M Bella, V Langer, J Fawcett, DR Russell, DJ Mansfield, M Valko, P Kočovský

Organometallics

(2001)

673

(doi: 10.1021/om000850m)