Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Butane-2,3-Diacetal-Desymmetrized Glycolic Acid—A New Building Block for the Stereoselective Synthesis of Enantiopureα-Hydroxy Acids

E Díez, DJ Dixon, SV Ley

Angewandte Chemie (International ed. in English)

(2001)

2906

(doi: 10.1002/1521-3773(20010803)40:15<2906::aid-anie2906>3.0.co;2-5)

Looking to the future

S Ley

CHEMISTRY IN BRITAIN

(2001)

Development and application of a carbonyl-13C-enriched backbone amide linker for solid-phase reaction monitoring

C Jamieson, MS Congreve, PR Hewitt, JJ Scicinski, SV Ley

Journal of Combinatorial Chemistry

(2001)

397

(doi: 10.1021/cc010012w)

Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs.

JJ Scicinski, MS Congreve, C Jamieson, SV Ley, ES Newman, VM Vinader, RA Carr

ACS Combinatorial Science

(2001)

387

(doi: 10.1021/cc0100114)

Data mining and the future of chemistry

S Ley

MANUFACTURING CHEMIST

(2001)

New catalysts for olefin metathesis

M Scholl, S Ding, CW Lee, RH Grubbs, PE Brennan, SV Ley, AK Chatterjee, JP Morgan

Chemtracts

(2001)

Studies toward the total synthesis of rapamycin.

SV Ley, PE Brennan

ABSTR PAP AM CHEM S

(2001)

221

U185

Approaches to the total synthesis of antascomicin A.

SV Ley, DEA Brittain, JS Barlow, MD Smith, K Yasuda

ABSTR PAP AM CHEM S

(2001)

221

U198

A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging

SV Ley, A Massi, F Rodríguez, DC Horwell, RA Lewthwaite, MC Pritchard, AM Reid

Angewandte Chemie International Edition

(2001)

1053

(doi: 10.1002/1521-3773(20010316)40:6<1053::AID-ANIE10530>3.0.CO;2-D)

A New Phase‐Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal‐Chelated Tagging

SV Ley, A Massi, F Rodríguez, DC Horwell, RA Lewthwaite, MC Pritchard, AM Reid

Angewandte Chemie International Edition

(2001)

1053

(doi: 10.1002/1521-3773(20010316)40:6<1053::aid-anie10530>3.0.co;2-d)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge