Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Palladium Acetate in Polyurea Microcapsules: A Recoverable and Reusable Catalyst for Hydrogenations

SV Ley, N Bremeyer, C Ramarao, IM Shirley, SC Smith

Synlett

(2002)

2002

1843

(doi: 10.1055/s-2002-34862)

Preface

SV Ley

(2002)

vii

(doi: 10.1016/S1572-5995(02)80031-X)

Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative

DJ Dixon, SV Ley, F Rodríguez

Angewandte Chemie International Edition

(2001)

4763

(doi: 10.1002/1521-3773(20011217)40:24<4763::AID-ANIE4763>3.0.CO;2-D)

Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers

IR Baxendale, G Brusotti, M Matsuoka, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(2001)

143

(doi: 10.1039/b109482n)

Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters

DJ Dixon, SV Ley, A Polara, T Sheppard

Organic Letters

(2001)

3749

(doi: 10.1021/ol016707n)

Highly diastereoselective Michael addition reactions of butane-2,3-diacetal desymmetrized glycolic acid. Preparation of α-hydroxy-γ-amino acid derivatives

DJ Dixon, SV Ley, F Rodríguez

Organic letters

(2001)

3753

(doi: 10.1021/ol016708f)

Tetra-N-propylammonium perruthenate:: a case study in catalyst recovery and re-use involving tetraalkylammonium salts

SV Ley, C Ramarao, MD Smith

Chemical Communications

(2001)

2278

(doi: 10.1039/b107966m)

Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (Râ€²,Râ€²,S,R)-2,3-butane diacetal protected butanetetraol derivatives

DJ Dixon, L Krause, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2001)

2516

(doi: 10.1039/b105118k)