Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
J. Chem. Soc., Perkin Trans. 1
(2002)
2
2237
(doi: 10.1039/b207068p)
Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative
Angewandte Chemie International Edition
(2001)
40
4763
Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers
J CHEM SOC PERK T 1
(2001)
2
143
(doi: 10.1039/b109482n)
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
Canadian Journal of Chemistry
(2001)
79
1668
(doi: 10.1139/v01-144)
Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.
Organic Letters
(2001)
3
3749
(doi: 10.1021/ol016707n)
Highly diastereoselective Michael addition reactions of butane-2,3-diacetal desymmetrized glycolic acid. Preparation of alpha-hydroxy-gamma-amino acid derivatives
Org Lett
(2001)
3
3753
(doi: 10.1021/ol016708f)
Tetra-N-propylammonium perruthenate:: a case study in catalyst recovery and re-use involving tetraalkylammonium salts
Chemical Communications
(2001)
1
2278
(doi: 10.1039/b107966m)
Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (R′,R′,S,R)-2,3-butane diacetal protected butanetetraol derivatives
J CHEM SOC PERK T 1
(2001)
1
2516
(doi: 10.1039/b105118k)
The Bestmann ylide as a multi-purpose wittig reagent
Chemtracts
(2001)
14
386
Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito
Mol Biochem Parasitol
(2001)
116
17
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