Professor Steven V. Ley Research Group

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

NITROGEN ANALOGS OF 1,6-METHANO[12]ANNULENE - EFFECT ON VALENCE TAUTOMERISM OF LOCUS OF AZA SUBSTITUTION
LA PAQUETTE, HC BERK, SV LEY
The Journal of Organic Chemistry
(2002)
40
(doi: 10.1021/jo00895a020)
Thermal Isomerization of Homoazocines
GD Ewing, SV Ley, LA Paquette
Journal of the American Chemical Society
(2002)
100
(doi: 10.1021/ja00477a066)
Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts
LA PAQUETTE, SV LEY, S MAIORANA, DF SCHNEIDER, MJ BROADHURST, RA BOGGS
Journal of the American Chemical Society
(2002)
97
(doi: 10.1021/ja00849a031)
Immobilization of Thallium by Tandem Oxidation/Reduction-Complexation of Thallium(I/III)
IA KAHWA, D MILLER, M MITCHEL, FR FRONCZEK, RG GOODRICH, DJ WILLIAMS, CA OMAHONEY, AMZ SLAWIN, SV LEY, CJ GROOMBRIDGE
Inorganic Chemistry
(2002)
31
(doi: 10.1021/ic00045a020)
Directed syntheses of the isomeric dimethylcyclooctatetraenes and a study of their polarographic and alkali metal reduction
LA PAQUETTE, SV LEY, MEISINGE.RH, RK RUSSELL, M OKU
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00825a019)
Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10.pi. homoaromatic dianions
LA Paquette, GD Ewing, SV Ley, HC Berk, SG Traynor
The Journal of Organic Chemistry
(2002)
43
(doi: 10.1021/jo00419a007)
Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10.pi. homoaromatic dianions
LA PAQUETTE, GD EWING, SV LEY, HC BERK, SG TRAYNOR
The Journal of Organic Chemistry
(2002)
43
(doi: 10.1021/jo00419a007)
Alkali metal reduction studies of cis- and trans-bicyclo[6.1.0]nona-2,4,6-trienes in liquid ammonia. Evidence for the high basicity of monohomocyclooctatetraene dianions
SV LEY, LA PAQUETTE
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00828a021)
Encapsulation of palladium in polyurea microcapsules.
C Ramarao, SV Ley, SC Smith, IM Shirley, N DeAlmeida
Chem Commun (Camb)
(2002)
10
(doi: 10.1039/b200674j)
Polyurea-encapsulated palladium( ii ) acetate: a robust and recyclable catalyst for use in conventional and supercritical media
SV Ley, C Ramarao, RS Gordon, AB Holmes, AJ Morrison, IF McConvey, IM Shirley, SC Smith, MD Smith
Chemical Communications
(2002)
2
(doi: 10.1039/b200677b)

Research Interest Groups

Synthetic Chemistry
Biological
Materials Chemistry

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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