Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Solid-supported reagents for multi-step organic synthesis: Preparation and application

SV Ley, IR Baxendale, G Brusotti, M Caldarelli, A Massi, M Nesi

Il Farmaco

(2002)

57

321

(doi: 10.1016/S0014-827X(02)01210-7)

Analytical construct resins for analysis of solid-phase chemistry.

MS Congreve, SV Ley, JJ Scicinski

Chemistry - A European Journal

(2002)

8

1768

(doi: 10.1002/1521-3765(20020415)8:8<1768::aid-chem1768>3.0.co;2-j)

The total synthesis of the annonaceous acetogenin, muricatetrocin C.

DJ Dixon, SV Ley, DJ Reynolds

Chemistry (Weinheim an der Bergstrasse, Germany)

(2002)

8

1621

(doi: 10.1002/1521-3765(20020402)8:7<1621::AID-CHEM1621>3.0.CO;2-8)

The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids

K Yasuda, SV Ley

J CHEM SOC PERK T 1

(2002)

2

1024

(doi: 10.1039/b201776h)

The use of π-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides α- and β-zearalenol

S Burckhardt, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2002)

2

874

(doi: 10.1039/b201164f)

Total synthesis of the cyclic heptapeptide Argyrin B: a new potent inhibitor of T-cell independent antibody formation.

SV Ley, A Priour, C Heusser

Org Lett

(2002)

4

711

(doi: 10.1021/ol017184m)

The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells

A Salehzadeh, A Jabbar, L Jennens, SV Ley, RS Annadurai, R Adams, RHC Strang

Pest Manag Sci

(2002)

58

268

(doi: 10.1002/ps.449)

Reductive decomplexation of pi-allyltricarbonyliron lactone complexes; a new route to stereo-defined 1,7-diols and 2,3-diene-1,7-diols.

CJ Hollowood, SV Ley

Chem Commun (Camb)

(2002)

2

2130

(doi: 10.1039/b206406p)

Preface

SV Ley

(2002)

27

vii

(doi: 10.1016/s1572-5995(02)80031-x)

A Polymer-supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds

IR Baxendale, A-L Lee, SV Ley

Synlett

(2002)

2002

516

(doi: 10.1055/s-2002-20483)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140