Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids

K Yasuda, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(2002)

1024

(doi: 10.1039/b201776h)

The use of π-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides α- and β-zearalenol

S Burckhardt, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2002)

874

(doi: 10.1039/b201164f)

Total synthesis of the cyclic heptapeptide Argyrin B: A new potent inhibitor of T-cell independent antibody formation

SV Ley, A Priour, C Heusser

Organic Letters

(2002)

711

(doi: 10.1021/ol017184m)

The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells

A Salehzadeh, A Jabbar, L Jennens, SV Ley, RS Annadurai, R Adams, RHC Strang

Pest Management Science

(2002)

268

(doi: 10.1002/ps.449)

Where are the women presidents? - Reply

S Ley

CHEMISTRY IN BRITAIN

(2002)

A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds

IR Baxendale, A-L Lee, SV Ley

Synlett

(2002)

2002

0516

(doi: 10.1055/s-2002-20483)

Reductive decomplexation of π-allyltricarbonyliron lactone complexes; a new route to stereo-defined 1,7-diols and 2,3-diene-1,7-diols

CJ Hollowood, SV Ley

Chemical Communications

(2002)

2130

(doi: 10.1039/b206406p)

A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative

RN Bream, SV Ley, B McDermott, PA Procopiou

J. Chem. Soc., Perkin Trans. 1

(2002)

2237

(doi: 10.1039/b207068p)