Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis, structure revision, and absolute configuration of (+)-didemniserinolipid B, a serinol marine natural product from a tunicate Didemnum sp.
Organic Letters
(2002)
4
3223
(doi: 10.1021/ol026421y)
The synthesis of salmeterol using solid supported reagents.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U115
Synthetic studies toward the total synthesis of Azadirachtin.
ABSTR PAP AM CHEM S
(2002)
224
U242
Total synthesis of Argyrin B.
ABSTR PAP AM CHEM S
(2002)
224
U242
Application of analytical constructs to the development of an indole safety-catch linker family for solid phase organic synthesis.
ABSTR PAP AM CHEM S
(2002)
224
U175
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
Tetrahedron
(2002)
58
6285
Total synthesis of polycephalin C and determination of the absolute configurations at the 3",4" ring junction.
Angewandte Chemie International Edition
(2002)
41
2786
New tools and concepts for modern organic synthesis
Nature reviews. Drug discovery
(2002)
1
573
(doi: 10.1038/nrd871)
A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an ugi reaction.
Bioorg Med Chem Lett
(2002)
12
1813
A concise synthesis of carpanone using solid-supported reagents and scavengers
Journal of the Chemical Society, Perkin Transactions 1
(2002)
2
1850
(doi: 10.1039/b203388g)
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