Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Immobilization of thallium by tandem oxidation/reduction-complexation of thallium(I/III)

IA Kahwa, D Miller, M Mitchel, FR Fronczek, RG Goodrich, DJ Williams, CA O'Mahoney, AMZ Slawin, SV Ley, CJ Groombridge

Inorganic Chemistry

(2002)

31

3963

(doi: 10.1021/ic00045a020)

LUMINESCENCE DYNAMICS AND C-13 NMR CHARACTERISTICS OF DINUCLEAR COMPLEXES EXHIBITING COUPLED LANTHANIDE(III) CATION PAIRS

KD Matthews, SA Bailey-Folkes, IA Kahwa, GL McPherson, CA O'Mahoney, SV Ley, DJ Williams, CJ Groombridge, CA O'Connor

Journal of Physical Chemistry

(2002)

96

7021

(doi: 10.1021/j100196a033)

HOMOTROPYLIUM-8-SULFINATE COMPLEXES BY SBF5-PROMOTED RING-OPENING OF 9-THIABICYCLO[4.2.1]NONA-2,4,7-TRIENE AND 9-THIABARBARALANE 9,9-DIOXIDES

LA Paquette, U Jacobsson, SV Ley

Journal of the American Chemical Society

(2002)

98

152

(doi: 10.1021/ja00417a023)

Formation of Monohomocyclooctatetraene Dianions in Liquid Ammonia. Analysis of the Nucleophilic Reactivity of the Cyclononatrienyl Anions Generated Upon Solvent Protonation

LA Paquette, SV Ley, SG Traynor, JT Martin, JM Geckle

Journal of the American Chemical Society

(2002)

98

8162

(doi: 10.1021/ja00441a046)

The question of delocalization in "anchored" ions with potential trishomoaromatic character. 1. Reduction of tricyclo[5.4.1.04,12]dodeca-2,5,8,10-tetraene as a route to the 10.pi.11C dianion

LA Paquette, MJ Kukla, SV Ley, SG Traynor

Journal of the American Chemical Society

(2002)

99

4756

(doi: 10.1021/ja00456a037)

EFFICIENT SYNTHESIS OF (-)-TRIQUINACENE-2-CARBOXYLIC ACID

LA Paquette, SV Ley, WB Farnham

Journal of the American Chemical Society

(2002)

96

312

(doi: 10.1021/ja00808a081)

Directed Syntheses of the Isomeric Dimethylcyclooctatetraenes and a Study of Their Polarographic and Alkali Metal Reduction

LA Paquette, SV Ley, RH Meisinger, RK Russell, M Oku

Journal of the American Chemical Society

(2002)

96

5806

(doi: 10.1021/ja00825a019)

ALKALI-METAL REDUCTION STUDIES OF CIS-BICYCLO AND TRANS-BICYCLO[610]NONA-2,4,6-TRIENES IN LIQUID-AMMONIA - EVIDENCE FOR HIGH BASICITY OF MONOHOMOCYCLOOCTATETRAENE DIANIONS

SV Ley, LA Paquette

Journal of the American Chemical Society

(2002)

96

6670

(doi: 10.1021/ja00828a021)

Tetracyanoethylene Addition to Iron Tricarbonyl Complexes of Substituted Cyclooctatetraenes. Regioselectivity Considerations during Formation of the 2,3,4,10-Tetrahapto Adducts

LA Paquette, SV Ley, S Maiorana, DF Schneider, MJ Broadhurst, RA Boggs

Journal of the American Chemical Society

(2002)

97

4658

(doi: 10.1021/ja00849a031)

A facile route to imidazol-4-yl anions and their reaction with carbonyl compounds

RM Turner, SD Lindell, SV Ley

The Journal of Organic Chemistry

(2002)

56

5739

(doi: 10.1021/jo00020a002)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140