Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins

MJ Gaunt, DF Hook, HR Tanner, SV Ley

Organic Letters

(2003)

4815

(doi: 10.1021/ol035848h)

Modern synthetic methods for copper-mediated C(aryl)-O, C(aryl)-N, and C(aryl)-S bond formation

SV Ley, AW Thomas

Angewandte Chemie International Edition

(2003)

5400

(doi: 10.1002/anie.200300594)

Synthesis of the C-1-C-28 ABCD Unit of Spongistatin 1

MJ Gaunt, AS Jessiman, P Orsini, HR Tanner, DF Hook, SV Ley

Organic letters

(2003)

4819

(doi: 10.1021/ol035849+)

Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for Hydrogenolysis of Epoxides

SV Ley, C Mitchell, D Pears, C Ramarao, J-Q Yu, W Zhou

Org Lett

(2003)

4665

(doi: 10.1021/ol0358509)

Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplings

MD Smith, AF Stepan, C Ramarao, PE Brennan, SV Ley

Chemical communications (Cambridge, England)

(2003)

2652

(doi: 10.1039/b308465e)

A convenient route to enantiomerically pure 2-substituted methyl glycerate derivatives.

SV Ley, P Michel, C Trapella

Org Lett

(2003)

4553

(doi: 10.1021/ol035567+)

A sequential tetra-n-propylammonium perruthenate (TPAP) - Wittig oxidation olefination protocol

RN MacCoss, EP Balskus, SV Ley

Tetrahedron Letters

(2003)

7779

(doi: 10.1016/j.tetlet.2003.08.081)

Total synthesis of the polyenoyltetramic acid polycephalin C

DA Longbottom, AJ Morrison, DJ Dixon, SV Ley

Tetrahedron

(2003)

6955

(doi: 10.1016/s0040-4020(03)00816-0)

Synthesis, Chiroptical Properties, and Absolute Configuration of (+)-2,3-Dihydrotriquinacen-2-one. Effect of Rigid Triquinacene Geometry on the Inherently Dissymmetric Chromophore

L Paquette, W Farnham, S Ley

Journal of the American Chemical Society

(2003)

7273

(doi: 10.1021/ja00858a600)

Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

RN MacCoss, PE Brennan, SV Ley

Organic & Biomolecular Chemistry

(2003)

2029

(doi: 10.1039/b303951j)