Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Grignard additions to 2-uloses: Synthesis of stereochemically pure tertiary alcohols

E Cleator, CF McCusker, F Steltzer, SV Ley

Tetrahedron Letters

(2004)

3077

(doi: 10.1016/j.tetlet.2004.02.106)

Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.

E Vickerstaffe, BH Warrington, M Ladlow, SV Ley

Journal of Combinatorial Chemistry

(2004)

332

(doi: 10.1021/cc049977g)

Development of an Indole Safety-Catch Linker Using Analytical Constructs

JJ Scicinski, MS Congreve, SV Ley

Journal of Combinatorial Chemistry

(2004)

375

(doi: 10.1021/cc0499791)

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (γ)- and pyranyl (δ)-lactols

MF Buffet, DJ Dixon, SV Ley, DJ Reynolds, RI Storer

Organic & biomolecular chemistry

(2004)

1145

(doi: 10.1039/b316858a)

Catalytic Polymer-Supported Potassium Thiophenolate in Methanol as a Method for the Removal of Ester, Amide, and Thioacetate Protecting Groups

RN MacCoss, DJ Henry, CT Brain, SV Ley

Synlett

(2004)

675

(doi: 10.1055/s-2004-817786)

5-pyrrolidin-2-yltetrazole: A new, catalytic, more soluble alternative to proline in an organocatalytic asymmetric Mannich-type reaction

AJA Cobb, DM Shaw, SV Ley

Synlett

(2004)

2004

558

(doi: 10.1055/s-2004-817745)

Modern synthetic methods for copper-mediated C(aryl)-O, C(aryl)N, and C(aryl)-S bond formation (vol 42, pg 5400, 2003)

SV Ley, AW Thomas

Angewandte Chemie International Edition

(2004)

1043

(doi: 10.1002/anie.200490023)

Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors

A Bapna, E Vickerstaffe, BH Warrington, M Ladlow, T-PD Fan, SV Ley

Organic & biomolecular chemistry

(2004)

611

(doi: 10.1039/b313414h)

Preface - In honor of Professor Leo A. Paquette and on the occasion of his 70th birthday

SV Ley

HETEROCYCLES

(2004)

The synthesis of (-)-gloeosporone, a potent fungal autoinhibitor of spore germination using a pi-allyltricarbonyl-iron lactone complex and a new reductive decomplexation procedure for the installation of the embedded 1,7-diol component of the natural product

E Cleator, J Harter, SV Ley

Heterocycles

(2004)

619

(doi: 10.3987/com-03-s(p)55)