Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES

SV LEY, AJ REDGRAVE, LL YEUNG

ACS SYM SER

(1991)

463

132

TOTAL SYNTHESIS OF THE ANTHELMINTIC MACROLIDE AVERMECTIN B1A

SV Ley, A Armstrong, D Díez-Martín, MJ Ford, P Grice, JG Knight, HC Kolb, A Madin, CA Marby, S Mukherjee, AN Shaw, AMZ Slawin, S Vile, AD White, DJ Williams, M Woods

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1991)

667

(doi: 10.1039/p19910000667)

SYNTHESIS OF INSECT ANTIFEEDANTS

SV LEY

PESTICIDE CHEMISTRY : ADVANCES IN INTERNATIONAL RESEARCH, DEVELOPMENT, AND LEGISLATION

(1991)

A new ruthenium(VI) oxidant: preparation, X-ray crystal structure, and properties of (Ph4P)[RuO2(OAc)Cl2]

WP Griffith, JM Jolliffe, SV Ley, DJ Williams

Chemical Communications

(1990)

1219

(doi: 10.1039/C39900001219)

AN EFFICIENT 3-STEP SYNTHESIS OF L-(-)-OLEANDROSE FROM (S)-(-)-METHYL LACTATE

M Ford*, S Ley

Synlett

(1990)

1990

771

(doi: 10.1055/s-1990-21247)

Direct substitution of 2-phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by alkyl organometallic reagents in dichloromethane

D Brown*, P Charreau, S Ley

Synlett

(1990)

1990

749

(doi: 10.1055/s-1990-21237)

DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE

DS BROWN, P CHARREAU, SV LEY

SYNLETT

(1990)

749

SYNTHESIS OF BIOLOGICALLY-ACTIVE CYCLITOLS VIA MICROBIAL OXIDATION OF BENZENE

SV LEY, AJ REDGRAVE

ABSTR PAP AM CHEM S

(1990)

200

USE OF MICROBIAL OXIDANTS FOR THE PREPARATION OF INOSITOL DERIVATIVES AND RELATED CYCLITOLS

SV LEY

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(1990)

200

123

NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES

SV LEY

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(1990)

200

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

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