Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The use of π-allyltricarbonyliron lactone complexes in the synthesis of the β-lactone esterase inhibitor (−)-valilactone.
Tetrahedron
(1991)
47
9929
Synthesis of the alkaloids (−)-heliotridane and (−)-isoretronecanol via π-allyltricarbonyliron lactam complexes.
Tetrahedron Letters
(1991)
32
7119
(doi: 10.1016/0040-4039(91)85056-b)
Chemistry of insect antifeedants from Azadirachta indica (part 11): Characterisation and structure activity relationships of some novel rearranged azadirachtins.
Tetrahedron
(1991)
47
9231
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .10. SYNTHESIS OF A HIGHLY FUNCTIONALIZED DECALIN FRAGMENT OF AZADIRACHTIN
Tetrahedron Letters
(1991)
32
6187
(doi: 10.1016/0040-4039(91)80785-5)
Chemistry of insect antifeedants from azadirachta indica (Part 9): oxidative reactions of azadirachtin derivatives leading to C8-C14 bond cleavage.
Tetrahedron Letters
(1991)
32
6183
(doi: 10.1016/0040-4039(91)80784-4)
THE TOTAL SYNTHESIS OF AGGLOMERIN-A AND (+/-)-CAROLINIC ACID - A GENERAL-METHOD FOR THE PREPARATION OF 3-ACYL TETRONIC ACIDS VIA DIRECT ACYLATION OF O-METHYL 3-STANNYL TETRONATES
Tetrahedron
(1991)
47
8285
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .8. SYNTHESIS OF HYDROXYDIHYDROFURAN ACETAL FRAGMENTS FOR BIOLOGICAL EVALUATION AND AZADIRACHTIN TOTAL SYNTHESIS STUDIES
Tetrahedron
(1991)
47
6813
Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes.
Tetrahedron Letters
(1991)
32
2651
Use of Phenylsulphonylmethano Ethers in Synthesis: A New Versatile Route to Substituted Cyclic Ethers
Synlett
(1991)
1991
415
(doi: 10.1055/s-1991-20747)
SUBSTITUTION-REACTIONS OF 2-PHENYLSULFONYL-PIPERIDINES AND 2-PHENYLSULFONYL-PYRROLIDINES WITH CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOIDS NORRUSPOLINE AND RUSPOLINONE
Tetrahedron
(1991)
47
1311
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