Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Microwave promoted hydrolysis of esters absorbed on alumina: A new deprotection method for pivaloyl groups

SV LEY, DM MYNETT

Synlett

(1993)

1993

793

(doi: 10.1055/s-1993-22612)

SYNTHESIS OF 4-SUBSTITUTED IMIDAZOLES VIA 4-METALLO IMIDAZOLE INTERMEDIATES

RM TURNER, SV LEY, SD LINDELL

Synlett

(1993)

1993

748

(doi: 10.1055/s-1993-22594)

Dispiroketals in synthesis (part 4): Enantioselective desymmetrization of glycerol using a c2-symmetric disubstituted bis-dihydropyran.

GJ BOONS, DA ENTWISTLE, SV LEY, M WOODS

Tetrahedron Letters

(1993)

5649

(doi: 10.1016/s0040-4039(00)73906-2)

Chemistry of insect antifeedants from Azadirachta Indica (Part 15):1 Degradation studies of Azadirachtin leading to C8C14 bond cleavage.

SV LEY, PJ LOVELL, AMZ SLAWIN, SC SMITH, DJ WILLIAMS, A WOOD

Tetrahedron

(1993)

1675

(doi: 10.1016/S0040-4020(01)80354-9)

Dispiroketals in Synthesis (Part 3):¹Selective Protection of Diequatorial Vicinal Diols in Carbohydrates

SV LEY, GJ BOONS, R LESLIE, M WOODS, DM HOLLINSHEAD

Synthesis

(1993)

1993

689

(doi: 10.1055/s-1993-25923)

UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA

PA PARANAGAMA, H LOVELL, AA DENHOLM, SV LEY, JD CONNOLLY, RHC STRANG

Journal of Insect Physiology

(1993)

935

(doi: 10.1016/0022-1910(93)90003-A)

Some alkylation and reductive amination studies of β-ketomacrolides as potential metal speciation materials

SV KELKAR, SV LEY

Heterocycles

(1993)

263

(doi: 10.3987/com-92-s12)

Alfred bader [2]

SV Ley

Chemical and Engineering News

(1992)

Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene

SV LEY, LL YEUNG

Synlett

(1992)

1992

997

(doi: 10.1055/s-1992-21561)

Chemistry of insect antifeedants from Azadirachta indica (part 12): use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin

HC KOLB, SV LEY, AMZ SLAWIN, DJ WILLIAMS

Journal of the Chemical Society Perkin Transactions 1

(1992)

2735

(doi: 10.1039/P19920002735)