Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Editorial: Harmonische Zusammenarbeit von Mensch und Maschine in der chemischen Synthese

SV Ley

Angewandte Chemie

(2018)

130

5278

(doi: 10.1002/ange.201802383)

Diastereoselective synthesis of functionalized indolines using in situ generated allyl boronic species.

S Ley, J Pastre, J Forni, S-H Lau, J-S Poh, C Battilocchio

Synlett

(2018)

825

(doi: 10.1055/s-0036-1589164)

Rapid, selective and stable HaloTag- Lb ADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides

J Döbber, M Pohl, SV Ley, B Musio

Reaction Chemistry & Engineering

(2018)

(doi: 10.1039/c7re00173h)

Award Address (Arthur C. Cope Award sponsored by the Arthur C. Cope Fund). Natural product synthesis as an inspiration for discovery

S Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

256

Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow

F Lima, L Grunenberg, HBA Rahman, R Labes, J Sedelmeier, SV Ley

Chemical communications (Cambridge, England)

(2018)

5606

(doi: 10.1039/c8cc02169d)

Preparation of homoallylic amines via a three-component coupling process.

X Ou, R Labes, C Battilocchio, S Ley

Org Biomol Chem

(2018)

6652

(doi: 10.1039/C8OB01831F)

Real-time spectroscopic analysis enabling quantitative and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow.

B Musio, E Gala, SV Ley

ACS Sustainable Chemistry and Engineering

(2018)

1489

(doi: 10.1021/acssuschemeng.7b04012)

Immobilized Reagents and Multistep Processes

SV Ley, DL Browne, M O'Brien

(2018)

2018

273

(doi: 10.1055/sos-SD-228-00177)

C-H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow.

P Dingwall, A Greb, LNS Crespin, R Labes, B Musio, J-S Poh, P Pasau, DC Blakemore, SV Ley

Chemical Communications

(2018)

11685

(doi: 10.1039/c8cc06202a)

Engineering Chemistry to Enable Bioactive Small Molecule Discovery

SV Ley, D Fitzpatrick, C Battilocchio

(2018)

184

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge