Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone

SV Ley, M O'Brien

Tetrahedron

(2018)

5319

(doi: 10.1016/j.tet.2018.06.041)

A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles

SV Ley, E Godineau, C Battilocchio, M Lehmann, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, AC O'Sullivan

OPRD

(2018)

(doi: 10.1021/acs/oprd.8b00095)

A Convergent Continuous Multistep Process for the Preparation of C4‑Oxime-Substituted Thiazoles

E Godineau, C Battilocchio, M Lehmann, SV Ley, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, ACC O'sullivan

Organic Process Research & Development

(2018)

955

(doi: 10.1021/acs.oprd.8b00095)