Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Grignard additions to 2-uloses: Synthesis of stereochemically pure tertiary alcohols

E Cleator, CF McCusker, F Steltzer, SV Ley

Tetrahedron Letters

(2004)

3077

(doi: 10.1016/j.tetlet.2004.02.106)

Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles

E Vickerstaffe, BH Warrington, M Ladlow, SV Ley

Journal of combinatorial chemistry

(2004)

332

(doi: 10.1021/cc049977g)

Development of an indole safety-catch linker using analytical constructs.

JJ Scicinski, MS Congreve, SV Ley

ACS Combinatorial Science

(2004)

375

(doi: 10.1021/cc0499791)

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (gamma)- and pyranyl (delta)-lactols

MF Buffet, DJ Dixon, SV Ley, DJ Reynolds, RI Storer

Organic and Biomolecular Chemistry

(2004)

1145

(doi: 10.1039/b316858a)

Catalytic Polymer-Supported Potassium Thiophenolate in Methanol as a Method for the Removal of Ester, Amide, and Thioacetate Protecting Groups

SV Ley, RN MacCoss, DJ Henry, CT Brain

Synlett

(2004)

675

(doi: 10.1055/s-2004-817786)

5-Pyrrolidin-2-yltetrazole: A New, Catalytic, More Soluble Alternative to Proline in an Organocatalytic Asymmetric Mannich-type Reaction

AJA Cobb, DM Shaw, SV Ley

Synlett

(2004)

2004

558

(doi: 10.1055/s-2004-817745)

Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors

A Bapna, E Vickerstaffe, BH Warrington, M Ladlow, T-PD Fan, SV Ley

Organic & biomolecular chemistry

(2004)

611

(doi: 10.1039/b313414h)

The synthesis of (-)-gloeosporone, a potent fungal autoinhibitor of spore germination using a π-allyltricarbonyl-iron lactone complex and a new reductive decomplexation procedure for the installation of the embedded 1,7-diol component of the natural product

S V. Ley, E Cleator, J Harter

Heterocycles

(2004)

619

(doi: 10.3987/com-03-s(p)55)

Preface - In honor of Professor Leo A. Paquette and on the occasion of his 70th birthday

SV Ley

HETEROCYCLES

(2004)

Synthesis of the nonamannan residue of a glycoprotein with high mannose content

P Grice, SV Ley, J Pietruszka, HWM Priepke

Angewandte Chemie International Edition in English

(2003)

197

(doi: 10.1002/anie.199601971)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge