Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

A new asymmetric organocatalytic nitrocyclopropanation reaction

HM Hansen, DA Longbottom, SV Ley

Chem Commun (Camb)

(2006)

4838

(doi: 10.1039/b612436b)

Sulphuration of Electron-Rich Arenes with Sulphenamides and Aminosulphenyl Chlorides

MU BOMBALA, SV LEY

Synthetic Communications

(2006)

10

291

(doi: 10.1080/00397918008062752)

Polymer-supported reagents and scavengers in synthesis

SV Ley, IR Baxendale, RM Myers

(2006)

3

791

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

M Baumann, IR Baxendale, SV Ley, CD Smith, GK Tranmer

Org Lett

(2006)

8

5231

(doi: 10.1021/ol061975c)

Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties.

JA Bull, EP Balskus, RAJ Horan, M Langner, SV Ley

Angewandte Chemie (International ed. in English)

(2006)

45

6714

(doi: 10.1002/anie.200602050)

An enantioselective organocatalytic route to chiral 3,6-dihydropyridazines from aldehydes

AJ Oelke, S Kumarn, DA Longbottom, SV Ley

Synlett

(2006)

2006

2548

(doi: 10.1055/s-2006-951486)

ORGN 141-Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst

KR Knudsen, CET Mitchell, S Brenner, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2006)

232

Enantioselective catalytic intramolecular cyclopropanation using modified cinchona alkaloid organocatalysts.

CCC Johansson, N Bremeyer, SV Ley, DR Owen, SC Smith, MJ Gaunt

Angew Chem Int Ed Engl

(2006)

45

6024

(doi: 10.1002/anie.200602129)

8,9,10,10a-Tetrahydro-6 H -tetrazolo[1,5- a ]pyrrolo[2,1- c ]pyrazines: New Heterocyclic Frameworks Generated by an Ugi-Type Multicomponent Reaction

V Franckevicius, DA Longbottom, RM Turner, SV Ley

Synthesis

(2006)

2006

3215

(doi: 10.1055/s-2006-950219)

Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat™ 30NP

SV Ley, AJP Stewart-Liddon, D Pears, RH Perni, K Treacher

Beilstein journal of organic chemistry

(2006)

2

15

(doi: 10.1186/1860-5397-2-15)

Research Interest Groups

Synthetic Chemistry

Materials Chemistry

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140