Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system

CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow

ACS Combinatorial Science

(2007)

9

422

(doi: 10.1021/cc060152b)

Total synthesis of rapamycin

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

Angewandte Chemie International Edition

(2007)

46

591

(doi: 10.1002/anie.200604053)

Total Synthesis of Thapsigargin, a Potent SERCA Pump Inhibitor

M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley

Organic Letters

(2007)

9

663

(doi: 10.1021/ol062947x)

Total synthesis of rapamycin.

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

Angew Chem Int Ed Engl

(2007)

46

591

(doi: 10.1002/anie.200604053)

Elastance of the morphologically unobtrusive aorta in teenagers with Marfan's syndrome:: Detection of early changes by means of MRT

JG Eichhorn, C Fink, R Krissak, HJ Ruediger, S Ley, R Arnold, M Khalil, H-U Kauczor, M Gorenflo, HE Ulmer

CLINICAL RESEARCH IN CARDIOLOGY

(2007)

96

695

Use of the Temporary Connection in Organic Synthesis

LR Cox, SV Ley

(2007)

274

(doi: 10.1002/9783527613526.ch10)

Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development

IR Baxendale, RM Myers, DA Longbottom, SV Ley

(2007)

51

Stent Imaging by means of 64-detector CT and 3-tesla-high field MRT in comparison with catheter angiography

JG Eichhorn, FR Long, S Hill, S Ley, M Gorenflo, R Arnold, H-U Kauczor, HE Ulmer, J Cheatham

CLINICAL RESEARCH IN CARDIOLOGY

(2007)

96

671

New avenues to efficient chemical synthesis

IR Baxendale, SV Ley

(2007)

151

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

IR Baxendale, SV Ley, CD Smith, GK Tranmer

Chemical communications (Cambridge, England)

(2006)

4835

(doi: 10.1039/b612197g)

Research Interest Groups

Synthetic Chemistry

Materials Chemistry

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140