Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Application of ultrasound to the preparation of tricarbonyliron diene complexes

SV LEY, CMR LOW, AD WHITE

Journal of Organometallic Chemistry

(1986)

302

C13

(doi: 10.1016/0022-328x(86)80072-9)

Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes

PS JONES, SV LEY, NS SIMPKINS, AJ WHITTLE

Tetrahedron

(1986)

6519

(doi: 10.1016/s0040-4020(01)88114-x)

Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V

SE DELASZLO, SV LEY, RA PORTER

J. Chem. Soc., Chem. Commun.

(1986)

344

(doi: 10.1039/C39860000344)

SYNTHETIC STUDIES TOWARDS THE ACYLTETRONIC ACID IONOPHORE M-139603

AM DOHERTY, SV LEY

Tetrahedron Letters

(1986)

105

(doi: 10.1016/s0040-4039(00)83953-2)

Ultrasonic formation and reactions of sodium phenylselenide

SV LEY, IA ONEIL, CMR LOW

Tetrahedron

(1986)

5363

(doi: 10.1016/s0040-4020(01)82086-x)

ALKYLATION REACTIONS OF ANIONS DERIVED FROM 2-BENZENESULFONYL TETRAHYDROPYRAN AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS

SV LEY, B LYGO, F STERNFELD, A WONNACOTT

Tetrahedron

(1986)

4333

(doi: 10.1016/S0040-4020(01)87660-2)

PREPARATION OF 2-SUBSTITUTED PYRROLES AND INDOLES BY REGIOSELECTIVE ALKYLATION AND DEPROTECTION OF 1-(2-TRIMETHYLSILYLETHOXYMETHYL)PYRROLE AND 1-(2-TRIMETHYLSILYLETHOXYMETHYL) INDOLE

MP EDWARDS, AM DOHERTY, SV LEY, HM ORGAN

Tetrahedron

(1986)

3723

(doi: 10.1016/s0040-4020(01)87342-7)

The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction

G BRUSSANI, SV LEY, JL WRIGHT, DJ WILLIAMS

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1986)

303

(doi: 10.1039/p19860000303)

X -Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin

HB BROUGHTON, SV LEY, AMZ SLAWIN, DJ WILLIAMS, ED MORGAN

Journal of the Chemical Society, Chemical Communications

(1986)

(doi: 10.1039/C39860000046)

Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: synthesis of the c-11 to c-25 fragment of the milbemycins

C GRECK, P GRICE, SV LEY, A WONNACOTT

Tetrahedron Letters

(1986)

5277

(doi: 10.1016/s0040-4039(00)85190-4)