Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Neo-clerodane insect antifeedants from Scutellaria galericulata

MD Cole, JC Anderson, WM Blaney, LE Fellows, SV Ley, RN Sheppard, MSJ Simmonds

Phytochemistry

(1990)

1793

(doi: 10.1016/0031-9422(90)85018-b)

Direct substitution of 2-benzenesulphonylpiperidines and - Pyrrolidines by carbon nucleophiles: Synthesis of the pyrrolidine alkaloid ruspolinone

D Brown*, T Hansson, S Ley

Synlett

(1990)

1990

(doi: 10.1055/s-1990-20983)

Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene

SV Ley, M Parra, AJ Redgrave, F Sternfeld

Tetrahedron

(1990)

4995

(doi: 10.1016/s0040-4020(01)85605-2)

Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexes

RW Bates, D Díez-Martín, WJ Kerr, JG Knight, SV Ley, A Sakellaridis

Tetrahedron

(1990)

4063

(doi: 10.1016/S0040-4020(01)90541-1)

TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols

WP Griffith, SV Ley

Aldrichimica Acta

(1990)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .6. SYNTHESIS OF AN OPTICALLY PURE ACETAL INTERMEDIATE FOR POTENTIAL USE IN THE SYNTHESIS OF AZADIRACHTIN AND NOVEL ANTIFEEDANTS

JC Anderson, SV Ley

Tetrahedron Letters

(1990)

431

(doi: 10.1016/S0040-4039(00)94574-X)

INSECT ANTIFEEDANTS

SV LEY, PL TOOGOOD

CHEMISTRY IN BRITAIN

(1990)

SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS

SV LEY

CIBA FOUNDATION SYMPOSIA

(1990)

154

Synthesis of the C12-C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)

SE de Laszlo, MJ Ford, SV Ley, GN Maw

Tetrahedron Letters

(1990)

5525

(doi: 10.1016/s0040-4039(00)97889-4)

Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).

SV Ley, GN Maw, ML Trudell

Tetrahedron Letters

(1990)

5521

(doi: 10.1016/s0040-4039(00)97888-2)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge