Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae.

MSJ Simmonds, WM Blaney, SV Ley, JC Anderson, PL Toogood

CrossRef Listing of Deleted DOIs

(1990)

169

(doi: 10.1007/bf00352578)

Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae.

WM Blaney, MSJ Simmonds, SV Ley, JC Anderson, PL Toogood

Entomologia experimentalis et applicata

(1990)

149

(doi: 10.1007/bf00352576)

A SIMPLE, ONE-POT, GLYCOSIDATION PROCEDURE VIA (1-IMIDAZOLYLCARBONYL) GLYCOSIDES AND ZINC BROMIDE

M Ford*, S Ley

Synlett

(1990)

1990

255

(doi: 10.1055/s-1990-21053)

Alkenylcyclic Sulphites as Novel Precursors for the Preparation of π-Allyltricarbonyliron Lactone Complexes

M Caruso*, J Knight, S Ley

Synlett

(1990)

1990

224

(doi: 10.1055/s-1990-21044)

DIRECT SUBSTITUTION OF 2-BENZENESULFONYLPIPERIDINES AND 2-BENZENESULFONYLPYRROLIDINES BY CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOID RUSPOLINONE

D Brown*, T Hansson, S Ley

Synlett

(1990)

1990

(doi: 10.1055/s-1990-20983)

ENANTIOSELECTIVE SYNTHESIS OF THE C3-C11 HYDROCARBON FRAGMENT OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI 139603)

SV Ley, GN Maw, ML Trudell

Tetrahedron Letters

(1990)

5521

(doi: 10.1016/s0040-4039(00)97888-2)

Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexes

RW Bates, D Díez-Martín, WJ Kerr, JG Knight, SV Ley, A Sakellaridis

Tetrahedron

(1990)

4063

(doi: 10.1016/s0040-4020(01)90541-1)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .6. SYNTHESIS OF AN OPTICALLY PURE ACETAL INTERMEDIATE FOR POTENTIAL USE IN THE SYNTHESIS OF AZADIRACHTIN AND NOVEL ANTIFEEDANTS

JC Anderson, SV Ley

Tetrahedron Letters

(1990)

431

(doi: 10.1016/s0040-4039(00)94574-x)

SYNTHESIS OF A C16-C28 SPIROACETAL FRAGMENT OF AVERMECTIN-B1A AND REASSIGNMENT OF SOME H-1 AND C-13 RESONANCES OF AVERMECTIN-B1A

D Diez-Martin, P Grice, HC Kolb, SV Ley, A Madin

Tetrahedron Letters

(1990)

3445

(doi: 10.1016/s0040-4039(00)97418-5)