Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Chemistry of insect antifeedants from Azadirachta indica, Part 14: Absolute configuration of azadirachtin

SV LEY, H LOVELL, DJ WILLIAMS

Chemical Communications

(1992)

1304

(doi: 10.1039/c39920001304)

Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)

D DIEZMARTIN, NR KOTECHA, SV LEY, S MANTEGANI, JC MENENDEZ, HM ORGAN, AD WHITE, BJ BANKS

Tetrahedron

(1992)

7899

(doi: 10.1016/S0040-4020(01)80467-1)

DISPIROKETALS IN SYNTHESIS .2. A NEW GROUP FOR THE SELECTIVE PROTECTION OF DIEQUATORIAL VICINAL DIOLS IN CARBOHYDRATES

SV LEY, R LESLIE, PD TIFFIN, M WOODS

Tetrahedron Letters

(1992)

4767

(doi: 10.1016/S0040-4039(00)61281-9)

BADER,ALFRED

SV LEY

CHEMICAL & ENGINEERING NEWS

(1992)

Oxidation of activated halides to aldehydes and ketones by n-methylmorpholine-n-oxide

WP GRIFFITH, JM JOLLIFFE, SV LEY, KF SPRINGHORN, PD TIFFIN

Synthetic Communications

(1992)

1967

(doi: 10.1080/00397919208021328)

TOTAL SYNTHESIS OF THE CARBOXYLIC-ACID IONOPHORE ANTIBIOTIC CP-61,405 (ROUTIENNOCIN)

NR KOTECHA, SV LEY, S MANTEGANI

Synlett

(1992)

1992

395

(doi: 10.1055/s-1992-21357)

TOTAL SYNTHESIS OF THE CARBOXYLIC-ACID IONOPHORE ANTIBIOTIC CP-61,405 (ROUTIENNOCIN) - PREPARATION OF THE INHERENT SPIROKETAL UNIT VIA A REVERSE COUPLING PROCESS

D DIEZMARTIN, NR KOTECHA, SV LEY, JC MENENDEZ

Synlett

(1992)

1992

399

(doi: 10.1055/s-1992-21358)

Microbial Oxidation in Synthesis: Preparation of Pseudo-α-D-glucopyranose from Benzene

SV LEY, LL YEUNG

Synlett

(1992)

1992

291

(doi: 10.1055/s-1992-21342)

FURTHER REACTIONS OF TERT-BUTYL 3-OXOBUTANTHIOATE AND TERT-BUTYL 4-DIETHYL-PHOSPHONO-3-OXOBUTANTHIOATE - CARBONYL COUPLING REACTIONS, AMINATION, USE IN THE PREPARATION OF 3-ACYLTETRAMIC ACIDS AND APPLICATION TO THE TOTAL SYNTHESIS OF FULIGORUBIN-A

SV LEY, SC SMITH, PR WOODWARD

Tetrahedron

(1992)

1145

(doi: 10.1016/s0040-4020(01)88210-7)

Chemistry of insect antifeedants from Azadirachta indica (part 13): on the use of the intramolecular Diels–Alder reaction for the construction of trans -fused hydrobenzofuran fragments for azadirachtin synthesis

HC KOLB, SV LEY, RN SHEPPARD, AMZ SLAWIN, SC SMITH, DJ WILLIAMS, A WOOD

J CHEM SOC PERK T 1

(1992)

2763

(doi: 10.1039/p19920002763)