Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Dispiroketals in synthesis (part 4): Enantioselective desymmetrization of glycerol using a c2-symmetric disubstituted bis-dihydropyran.

B Geert-Jan, DA Entwistle, SV Ley, M Woods

Tetrahedron Letters

(1993)

5649

(doi: 10.1016/s0040-4039(00)73906-2)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE

SV Ley, PJ Lovell, AMZ Slawin, SC Smith, DJ Williams, A Wood

Tetrahedron

(1993)

1675

(doi: 10.1016/S0040-4020(01)80354-9)

UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA

PA Paranagama, H Lovell, AA Denholm, SV Ley, JD Connolly, RHC Strang

Journal of Insect Physiology

(1993)

935

(doi: 10.1016/0022-1910(93)90003-A)

Dispiroketals in Synthesis (Part 3):¹Selective Protection of Diequatorial Vicinal Diols in Carbohydrates

S Ley*, G-J Boons, R Leslie, M Woods, D Hollinshead

Synthesis

(1993)

1993

689

(doi: 10.1055/s-1993-25923)

Some Alkylation and Reductive Amination Studies of b-Ketomacrolides as Potential Metal Speciation Materials

S V. Ley, S V. Kelkar

Heterocycles

(1993)

263

(doi: 10.3987/com-92-s12)

Alfred bader [2]

SV Ley

Chemical and Engineering News

(1992)

Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene

S Ley*, L Yeung

Synlett

(1992)

1992

997

(doi: 10.1055/s-1992-21561)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .12. USE OF SILICON AS A CONTROL ELEMENT IN THE SYNTHESIS OF A HIGHLY FUNCTIONALIZED DECALIN FRAGMENT OF AZADIRACHTIN

HC Kolb, SV Ley, AMZ Slawin, DJ Williams

Journal of the Chemical Society, Perkin Transactions 1

(1992)

2735

(doi: 10.1039/P19920002735)

Chemistry of insect antifeedants from Azadirachta indica , Part 14: absolute configuration of azadirachtin

SV Ley, H Lovell, DJ Williams

Journal of the Chemical Society, Chemical Communications

(1992)

1304

(doi: 10.1039/c39920001304)

Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)