Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Alfred bader [2]
Chemical and Engineering News
(1992)
70
2
Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene
Synlett
(1992)
1992
997
(doi: 10.1055/s-1992-21561)
Dispiroketals in synthesis (part 2): A new group for the selective protection of diequatorial vicinal diols in carbohydrates.
Tetrahedron Letters
(1992)
33
4767
BADER,ALFRED
CHEM ENG NEWS
(1992)
70
2
Oxidation of Activated Halides to Aldehydes and Ketones by N-Methylmorpholine-N-oxide
Synthetic Communications
(1992)
22
1967
(doi: 10.1080/00397919208021328)
TOTAL SYNTHESIS OF THE CARBOXYLIC-ACID IONOPHORE ANTIBIOTIC CP-61,405 (ROUTIENNOCIN) - PREPARATION OF THE INHERENT SPIROKETAL UNIT VIA A REVERSE COUPLING PROCESS
Synlett
(1992)
1992
399
(doi: 10.1055/s-1992-21358)
TOTAL SYNTHESIS OF THE CARBOXYLIC-ACID IONOPHORE ANTIBIOTIC CP-61,405 (ROUTIENNOCIN)
Synlett
(1992)
1992
395
(doi: 10.1055/s-1992-21357)
Microbial Oxidation in Synthesis: Preparation of Pseudo-α-D-glucopyranose from Benzene
Synlett
(1992)
1992
291
(doi: 10.1055/s-1992-21342)
ENABLING METHODOLOGY - THE SYNTHETIC CHEMISTS CONTRIBUTION TO MOLECULAR RECOGNITION
MOLECULAR RECOGNITION : CHEMICAL AND BIOCHEMICAL PROBLEMS II
(1992)
111
183
Further reactions of t-butyl 3-oxobutanthioate and t-butyl 4-diethyl-phosphono-3-oxobutanthioate : Carbonyl coupling reactions, amination, use in the preparation of 3-acyltetramic acids and application to the total synthesis of fuligorubin A.
Tetrahedron
(1992)
48
1145
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