Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

S Picaud, K Leonards, J-P Lambert, O Dovey, C Wells, O Fedorov, O Monteiro, T Fujisawa, C-Y Wang, H Lingard, C Tallant, N Nikbin, L Guetzoyan, R Ingham, SV Ley, P Brennan, S Muller, A Samsonova, A-C Gingras, J Schwaller, G Vassiliou, S Knapp, P Filippakopoulos

Science advances

(2016)

e1600760

(doi: 10.1126/sciadv.1600760)

Continuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy

B Ahmed-Omer, E Sliwinski, JP Cerroti, SV Ley

Organic Process Research & Development

(2016)

1603

(doi: 10.1021/acs.oprd.6b00177)

The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B.

S Fenner, ZE Wilson, SV Ley

Chemistry A European Journal

(2016)

15902

(doi: 10.1002/chem.201603157)

Flow chemistry in Europe

V Hessel, SV Ley

Journal of Flow Chemistry

(2016)

135

(doi: 10.1556/1846.2016.22222)

Taming hazardous chemistry by continuous flow technology.

M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens

Chemical Society reviews

(2016)

4892

(doi: 10.1039/c5cs00902b)

A multicomponent approach for the preparation of homoallylic alcohols.

J-S Poh, S-H Lau, IG Dykes, DN Tran, C Battilocchio, SV Ley

Chemical science

(2016)

6803

(doi: 10.1039/c6sc02581a)

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.

J-S Poh, C García-Ruiz, A Zúñiga, F Meroni, DC Blakemore, DL Browne, SV Ley

Organic & biomolecular chemistry

(2016)

5983

(doi: 10.1039/c6ob00970k)

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka, S Müller, S Knapp, JD Brenton, PE Brennan, SV Ley

Journal of medicinal chemistry

(2016)

5095

(doi: 10.1021/acs.jmedchem.5b01997)