Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Molybdenum(II)-catalyzed allylic substitution

AV Malkov, I Baxendale, DJ Mansfield, P Kočovsky

Tetrahedron Letters

(1997)

4895

(doi: 10.1016/s0040-4039(97)01052-6)

Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex

SV Ley, G Meek

J CHEM SOC PERK T 1

(1997)

1125

(doi: 10.1039/a607376j)

Synthesis and chemistry of dispiroacetals and other 1,2-diacetals.

SV Ley

ABSTR PAP AM CHEM S

(1997)

213

Dispiroketals in synthesis. Part 23.1 A new route to (+)- D -conduritol B from myo-inositol

JE Innes, PJ Edwards, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1997)

795

(doi: 10.1039/a700422b)

Preparation, structure, derivatisation and NMR data of cyclohexane-1,2-diacetal protected carbohydrates

P Grice, SV Ley, J Pietruszka, HWM Priepke, SL Warriner

Journal of the Chemical Society Perkin Transactions 1

(1997)

351

(doi: 10.1039/a605851e)

Autoradiographic localization of [22, 23-H-3(2)] dihydroazadirachtin binding sites in desert locust testes and effects of azadirachtin on sperm motility (vol 28, pg 725, 1996)

AJ Nisbet, AJ Mordue, LM Williams, L Hannah, L Jennens, SV Ley, W Mordue

TISSUE CELL

(1997)

129

One-Pot Synthesis of Tetra- and Pentasaccharides from Monomeric Building Blocks Using the Principles of Orthogonality and Reactivity Tuning

M-K Cheung, N Douglas, B Hinzen, S Ley*, X Pannecoucke

Synlett

(1997)

1997

257

(doi: 10.1055/s-1997-765)

A general C-glycosidation procedure via anomeric oxygen to carbon rearrangements of tetrahydropyranyl ether derivatives

M Buffet, D Dixon, G Edwards, S Ley*, E Tate

Synlett

(1997)

1997

1055

(doi: 10.1055/s-1997-1531)

Identification of azadirachtin in tissue-cultured cells of Neem (Azadirachta indica)

AP Jarvis, ED Morgan, SA Van Der Esch, F Vitali, SV Ley, A Pape

Natural Product Letters

(1997)

(doi: 10.1080/10575639708043721)

Dispiroketals in synthesis .22. Use of chiral 2,2'-bis(phenylthiomethyl)dihydropyrans as new protecting and resolving agents for 1,2-diols (pg 791, 1996)

SV Ley, S Mio, B Meseguer

SYNLETT

(1996)

932

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge