Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
COPPER(I)-CATALYZED PREPARATION OF (E)-3-IODOPROP-2-ENOIC ACID
Organic Syntheses
(2003)
80
129
(doi: 10.15227/orgsyn.080.0129)
Development of new synthetic tools for the preparation of biologically active molecules
CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129
235
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
Org. Biomol. Chem.
(2003)
1
15
(doi: 10.1039/b208982c)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
Use of pi-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase beta and HIV reverse transcriptase
Organic & Biomolecular Chemistry
(2003)
1
1664
(doi: 10.1039/b301676p)
Microencapsulation of Osmium Tetroxide in Polyurea
Organic letters
(2002)
5
185
(doi: 10.1021/ol020225+)
Benzotriazoles in solid-phase organic chemistry
Chemtracts
(2002)
15
751
Analytical techniques for small molecule solid phase synthesis.
Current Medicinal Chemistry
(2002)
9
2103
(doi: 10.2174/0929867023368737)
- ‹ previous
- Page 54
