Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of the C-1-C-28 ABCD unit of spongistatin 1

MJ Gaunt, AS Jessiman, P Orsini, HR Tanner, DF Hook, SV Ley

Organic Letters

(2003)

4819

(doi: 10.1021/ol035849+)

Modern synthetic methods for copper-mediated C(aryl)-O, C(aryl)-N, and C(aryl)-S bond formation

SV Ley, AW Thomas

Angew Chem Int Ed Engl

(2003)

5400

(doi: 10.1002/anie.200300594)

A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins

MJ Gaunt, DF Hook, HR Tanner, SV Ley

Org Lett

(2003)

4815

(doi: 10.1021/ol035848h)

Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for Hydrogenolysis of Epoxides

SV Ley, C Mitchell, D Pears, C Ramarao, J-Q Yu, W Zhou

Org Lett

(2003)

4665

(doi: 10.1021/ol0358509)

Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplings.

MD Smith, AF Stepan, C Ramarao, PE Brennan, SV Ley

Chem Commun (Camb)

(2003)

2652

(doi: 10.1039/b308465e)

A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives

SV Ley, P Michel, C Trapella

Org Lett

(2003)

4553

(doi: 10.1021/ol035567+)

A sequential tetra-n-propylammonium perruthenate (TPAP)–Wittig oxidation olefination protocol

RN MacCoss, EP Balskus, SV Ley

Tetrahedron Letters

(2003)

7779

(doi: 10.1016/j.tetlet.2003.08.081)

Total synthesis of the polyenoyltetramic acid polycephalin C

DA Longbottom, AJ Morrison, DJ Dixon, SV Ley

Tetrahedron

(2003)

6955

(doi: 10.1016/S0040-4020(03)00816-0)

SYNTHESIS, CHIROPTICAL PROPERTIES, AND ABSOLUTE-CONFIGURATION OF (+)-2,3-DIHYDROTRIQUINACEN-2-ONE - EFFECT OF RIGID TRIQUINACENE GEOMETRY ON INHERENTLY DISSYMMETRIC CHROMOPHORE

LA PAQUETTE, WB FARNHAM, SV LEY

Journal of the American Chemical Society

(2003)

7273

(doi: 10.1021/ja00858a600)

Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

E Vickerstaffe, BH Warrington, M Ladlow, SV Ley

Organic & Biomolecular Chemistry

(2003)

2419

(doi: 10.1039/b305713e)