Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

L Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle

Angewandte Chemie

(2007)

119

2545

(doi: 10.1002/ange.200604688)

Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells.

SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'

Arch Insect Biochem Physiol

(2007)

200

(doi: 10.1002/arch.20171)

Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow

Journal of Combinatorial Chemistry

(2007)

422

(doi: 10.1021/cc060152b)

Total synthesis of rapamycin

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

Angewandte Chemie International Edition

(2007)

591

(doi: 10.1002/anie.200604053)

Total synthesis of thapsigargin, a potent SERCA pump inhibitor.

M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley

Org Lett

(2007)

663

(doi: 10.1021/ol062947x)

Elastance of the morphologically unobtrusive aorta in teenagers with Marfan's syndrome:: Detection of early changes by means of MRT

JG Eichhorn, C Fink, R Krissak, HJ Ruediger, S Ley, R Arnold, M Khalil, H-U Kauczor, M Gorenflo, HE Ulmer

CLINICAL RESEARCH IN CARDIOLOGY

(2007)

695

Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development

IR Baxendale, RM Myers, DA Longbottom, SV Ley

(2007)

New avenues to efficient chemical synthesis

IR Baxendale, SV Ley

(2007)

151

Stent Imaging by means of 64-detector CT and 3-tesla-high field MRT in comparison with catheter angiography

JG Eichhorn, FR Long, S Hill, S Ley, M Gorenflo, R Arnold, H-U Kauczor, HE Ulmer, J Cheatham

CLINICAL RESEARCH IN CARDIOLOGY

(2007)

671

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

IR Baxendale, SV Ley, CD Smith, GK Tranmer

Chem Commun (Camb)

(2006)

4835

(doi: 10.1039/b612197g)

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

Papers of Interest

141. Preparation and use of tetra-n-propylammonium perruthenate (TPAP reagent) as new catalytic oxidants for alcohols J. Chem. Soc., Chem. Commun.,1987, 1625-1627.
659. The Synthesis of Azadirachtin Chem. Eur. J., 2008, 14, 10683-10704
366. Total synthesis of the protein phosphatase inhibitor okadaic acid J. Chem. Soc., Perkin Trans. 1, 1998, 3907-3912.
608. Total Synthesis of Rapamycin Angew. Chem., Int. Ed., 2007, 46, 591-597.
669. MultiStep Synthesis using Modular Flow Reactors Angew. Chem. Int. Ed., 2009, 48, 4017-4021
626. A Fascination with 1,2-Diacetals J. Org. Chem., 2007, 72, 5943-5959.
536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C Chem. Eur. J., 2004, 10, 2529-2547.
595. A Flow Process for the Multi-Step Synthesis of Oxomaritidine: A New Paradigm for Molecular Assembly J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
785. Accelerating spirocyclic polyketide synthesis using flow chemistry Angew. Chem. Int. Edn., 2014, 53, 4915-4920
854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters Angew. Chem. Int. Ed., 2017, 56, 15136-15140

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Interest Groups

Telephone number

Email address

College

Papers of Interest

About the Department

Departmental Services

Contact Professor Steven V. Ley Research Group

Study at Cambridge

About the University

Research at Cambridge