Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole
Synlett
(2011)
1375
(doi: 10.1055/s-0030-1260573)
The Continuous‐Flow Synthesis of Carboxylic Acids using CO2 in a Tube‐In‐Tube Gas Permeable Membrane Reactor
Angewandte Chemie
(2010)
123
1222
(doi: 10.1002/ange.201006618)
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor.
Organic letters
(2010)
13
320
(doi: 10.1021/ol1027927)
Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties.
Chemistry
(2010)
17
329
(doi: 10.1002/chem.201002380)
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proceedings of the National Academy of Sciences of the United States of America
(2010)
107
20483
(doi: 10.1073/pnas.1008255107)
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.
Org Biomol Chem
(2010)
9
57
(doi: 10.1039/c0ob00652a)
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor
Organic & biomolecular chemistry
(2010)
8
5324
(doi: 10.1039/c0ob00450b)
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