Professor Steve Ley CBE FRS FMedSci | Professor Steven V. Ley Research Group

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin

J Pastre, P Murray, D Browne, G Brancaglion, R Galaverna, R Pilli, SV Ley

ACS Omega

(2020)

5

18472

(doi: 10.1021/acsomega.0c02390)

In silico rationalisation of selectivity and reactivity in Pd-catalysed C–H activation reactions

L Cao, M Kabeshov, SV Ley, AA Lapkin

Beilstein Journal of Organic Chemistry

(2020)

16

1465

(doi: 10.3762/bjoc.16.122)

Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins.

SV Ley, Y Chen, N McNamara, O May, T Pillaiyara, D Blakemore

Organic letters

(2020)

22

5746

(doi: 10.1021/acs.orglett.0c01730)

In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions

L Cao, M Kabeshov, S Ley, A Lapkin

(2020)

(doi: 10.26434/chemrxiv.11961354.v2)

In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions

L Cao, M Kabeshov, S Ley, A Lapkin

(2020)

(doi: 10.26434/chemrxiv.11961354.v1)

A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions

DE Fitzpatrick, M O'Brien, SV Ley

Reaction Chemistry & Engineering

(2020)

5

201

(doi: 10.1039/c9re00407f)

A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.

E Watanabe, Y Chen, O May, SV Ley

Chemistry

(2019)

26

186

(doi: 10.1002/chem.201905048)

Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source

P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza

The Journal of organic chemistry

(2019)

84

14394

(doi: 10.1021/acs.joc.9b02453)

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

S Roy, J Sipthorp, B Mahata, J Pramanik, M Hennrich, A-C Gavin, S Ley, S Teichmann

(2019)

(doi: 10.1101/800649)

A New World for Chemical Synthesis?

S Ley, Y Chen, D Fitzpatrick, O May

Chimia

(2019)

73

792

(doi: 10.2533/chimia.2019.792)