Sulfone chemistry has played a wide role in much of our work.  The use of these methods in the construction of c-c bonds at anomeric carbon atoms and their use in natural product synthesis is particularly interesting.

Related Publications:

• Preparation and reactions of 2-benzenesulphonyltetrahydropyran S.V. Ley, B. Lygo, A. Wonnacott, Tetrahedron Lett. 1985, 26, 535-538.
• Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal synthesis S.V. Ley, B. Lygo, F. Sternfeld, A. Wonnacott, Tetrahedron 1986, 42, 4333-4342.
• Direct substitution of 2-benzenesulphonyl cyclic ethers using organozinc reagents D.S. Brown and S.V. Ley, Tetrahedron Lett. 1988, 29, 4869.
• Preparation of cyclic ether acetals from 2-benzenesulphonyl derivatives: a new mild glycosidation procedure D.S. Brown, S.V. Ley, S. Vile, Tetrahedron Lett. 1988, 29, 4873-4876.
• Substitution reactions of 2-benzenesulphonyl cyclic ethers with silyl enol ethers promoted by aluminium trichloride D.S. Brown, S.V. Ley, M. Bruno, Heterocycles 1989, 28, (Special Issue No. 2), 773-777.
• Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles D.S. Brown, M. Bruno, R.J. Davenport, S.V. Ley, Tetrahedron 1989, 45, 4293-4308.
• A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycin b1 S.V. Ley, N.J. Anthony, A. Armstrong, M.G. Brasca, T. Clarke, C. Greck, P. Grice, A.B. Jones, B. Lygo, A. Madin, R.N. Sheppard, A.M.Z. Slawin, D.J. Williams, Tetrahedron 1989, 45, 7161-7194.
• Direct substitution of 2-benzenesulphonyl-piperidines and -pyrrolidines by carbon nucleophiles: synthesis of the pyrrolidine alkaloid ruspolinone D.S. Brown, T. Hansson and S.V. Ley, Synlett, 1990, 48.
• Total synthesis of avermectin B1a: synthesis of the C11-C25 spiroacetal fragment D. Díez-Martín, P. Grice, H.C. Kolb, S.V. Ley, A. Madin, Synlett 1990, 326-328.
• Direct substitution of 2-phenylsulphonyl pyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by alkylorganometallic reagents in dichloromethane D.S. Brown, P. Charreau, S.V. Ley, Synlett, 1990, 749.
• Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids norruspoline and ruspolinone D.S. Brown, P. Charreau, T. Hansson, S.V. Ley, Tetrahedron, 1991, 47, 1311.
• Use of phenylsulphonylmethano ethers in synthesis: a new versatile route to substituted cyclic ethers P. Charreau, S.V. Ley, T.M. Vettiger, S.Vile, Synlett, 1991, 415.
• The Champagne Route to Avermectins and Milbemycins in Strategy and Tactics in Organic Synthesis Vol. 3, S.V. Ley and A. Armstrong, T. Lindberg, Ed. Acad. Press, 1991, 273-291.
• Total synthesis of the carboxylic acid ionophore antibiotic CP-61,405 (routiennocin) N.R. Kotecha, S.V. Ley, S. Mantegani, Synlett, 1992, 395.
• Total synthesis of the carboxylic acid ionophore antibiotic CP-61,405 (routiennocin): preparation of the inherent spiroketal unit via a reverse coupling process D. Diez-Martin, N.R. Kotecha, S.V. Ley, J.C. Menendez, Synlett, 1992, 399.
• Total synthesis of ionophore antibiotic CP-61,405 (routiennocin) D. Díez-Martin, N.R. Kotecha, S.V. Ley, S. Mantegani, J.C. Menéndez, H.M. Organ, A.D. White, B.J. Banks, Tetrahedron, 1992, 48, 7899.
• Total synthesis of the protein phosphatase inhibitor okadaic acid S.V Ley, A C. Humphries, H. Eick, R. Downham, A.R. Ross, R.J. Boyce, J.B.J. Pavey, J. Pietruszka, J. Chem. Soc., Perkin Trans. 1 1998, 3907-3912.
• Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor L. Malet-Sanz, J. Madrzak, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 5324-5332.
• Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins Y. Chen, N. McNamara, O. May, T. Pillaiyar, D. C. Blakemore, and S. V. Ley, Org. Lett. 2020, 22, 5746–5748. (https://doi.org/10.1021/acs.orglett.0c01730).
• Automated Multi-Objective Reaction Optimisation: Which Algorithm Should I Use?  P. Müller,  A. D. Clayton, J. Manson, S. Riley, O. S. May,  N. Govan, S. Notman, S. V. Ley,  T. W. Chamberlain and R. A. Bourne, Reac. Chem. Eng. 2022, 7, 987-993. (https://doi.org/10.1039/d1re00549a).
• Exploring the chemical space of phenyl sulfide oxidation by automated optimization P. Mueller,   A. Vriza,   A. D. Clayton,   O.S. May,   N. Govan,   S. Notman,  S. V. Ley,   T. W. Chamberlain  and  R. Bourne, React. Chem. Eng. 2023, 8, 538-542. (https://doi.org/10.1039/d2re00552b).
• Photoredox-Catalyzed Preparation of Sulfones Using Bis-Piperidine Sulfur Dioxide – An Underutilized Reagent for SO₂Transfer O.M. Griffiths, H.A. Esteves, D.C. Emmet and S.V. Ley Chem. Eur.J.,2024, 30, e202303976 (6 pages). (https://doi.org/10.1002/chem.202303976).